Interaction between Genetic Predisposition to Adiposity and Dietary Protein in Relation to Subsequent Change in Body Weight and Waist Circumference

Mikkel Zöllner Ankarfeldt, Sofus C Larsen, Lars Angquist, Lise Lotte N Husemoen, Nina Roswall, Kim Overvad, Marianne Uhre Jakobsen, Jytte Halkjær, Anne Tjønneland, Allan Linneberg, Ulla Toft, Torben Hansen, Oluf Pedersen, Berit L Heitmann, Arne Astrup, Thorkild I A Sørensen

    14 Citationer (Scopus)

    Abstract

    BACKGROUND: Genetic predisposition to adiposity may interact with dietary protein in relation to changes of anthropometry.

    OBJECTIVE: To investigate the interaction between genetic predisposition to higher body mass index (BMI), waist circumference (WC) or waist-hip ratio adjusted for BMI (WHRBMI) and dietary protein in relation to subsequent change in body weight (ΔBW) or change in WC (ΔWC).

    DESIGN: Three different Danish cohorts were used. In total 7,054 individuals constituted the study population with information on diet, 50 single-nucleotide polymorphisms (SNPs) associated with BMI, WC or WHRBMI, as well as potential confounders. Mean follow-up time was ∼5 years. Four genetic predisposition-scores were based on the SNPs; a complete-score including all selected adiposity- associated SNPs, and three scores including BMI, WC or WHRBMI associated polymorphisms, respectively. The association between protein intake and ΔBW or ΔWC were examined and interactions between SNP-score and protein were investigated. Analyses were based on linear regressions using macronutrient substitution models and meta-analyses.

    RESULTS: When protein replaced carbohydrate, meta-analyses showed no associations with ΔBW (41.0 gram/y/5 energy% protein, [95% CI: -32.3; 114.3]) or ΔWC (<-0.1 mm/y/5 energy % protein, [-1.1; 1.1]). Similarly, there were no interactions for any SNP-scores and protein for either ΔBW (complete SNP-score: 1.8 gram/y/5 energy% protein/risk allele, [-7.0; 10.6]) or ΔWC (complete SNP-score: <0.1 mm/y/5 energy% protein/risk allele, [-0.1; 0.1]). Similar results were seen when protein replaced fat.

    CONCLUSION: This study indicates that the genetic predisposition to general and abdominal adiposity, assessed by gene-scores, does not seem to modulate the influence of dietary protein on ΔBW or ΔWC.

    OriginalsprogEngelsk
    TidsskriftP L o S One
    Vol/bind9
    Udgave nummer10
    Sider (fra-til)e110890
    ISSN1932-6203
    DOI
    StatusUdgivet - 2014

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