Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer

Signe Benzon Larsen; Ulla Vogel; Jane Christensen; Rikke D Hansen; Håkan Wallin; Kim Overvad; Anne Tjønneland; Janne Tolstrup

doi:10.1016/j.canlet.2010.02.023

Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer

Signe Benzon Larsen, Ulla Vogel, Jane Christensen, Rikke D Hansen, Håkan Wallin, Kim Overvad, Anne Tjønneland, Janne Tolstrup

Afdeling for Hjerne- og Nervesygdomme

23 Citationer (Scopus)

Abstrakt

Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study. Among variant allele carriers of ADH1C Arg(272)Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04-1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.

Originalsprog	Engelsk
Tidsskrift	Cancer Letters
Vol/bind	295
Udgave nummer	2
Sider (fra-til)	191-7
Antal sider	7
ISSN	0304-3835
DOI	https://doi.org/10.1016/j.canlet.2010.02.023
Status	Udgivet - 28 sep. 2010

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10.1016/j.canlet.2010.02.023

Citationsformater

Benzon Larsen, S., Vogel, U., Christensen, J., Hansen, R. D., Wallin, H., Overvad, K., Tjønneland, A., & Tolstrup, J. (2010). Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer. Cancer Letters, 295(2), 191-7. https://doi.org/10.1016/j.canlet.2010.02.023

Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer. / Benzon Larsen, Signe; Vogel, Ulla; Christensen, Jane et al.

I: Cancer Letters, Bind 295, Nr. 2, 28.09.2010, s. 191-7.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Benzon Larsen, S, Vogel, U, Christensen, J, Hansen, RD, Wallin, H, Overvad, K, Tjønneland, A & Tolstrup, J 2010, 'Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer', Cancer Letters, bind 295, nr. 2, s. 191-7. https://doi.org/10.1016/j.canlet.2010.02.023

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title = "Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer",

abstract = "Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study. Among variant allele carriers of ADH1C Arg(272)Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04-1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.",

keywords = "Alcohol Dehydrogenase/genetics, Alcohol Drinking/adverse effects, Breast Neoplasms/etiology, Ethanol/adverse effects, Female, Humans, Middle Aged, Polymorphism, Genetic, Risk Factors",

author = "{Benzon Larsen}, Signe and Ulla Vogel and Jane Christensen and Hansen, {Rikke D} and H{\aa}kan Wallin and Kim Overvad and Anne Tj{\o}nneland and Janne Tolstrup",

year = "2010",

month = sep,

day = "28",

doi = "10.1016/j.canlet.2010.02.023",

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AU - Benzon Larsen, Signe

AU - Vogel, Ulla

AU - Christensen, Jane

AU - Hansen, Rikke D

AU - Wallin, Håkan

AU - Overvad, Kim

AU - Tjønneland, Anne

AU - Tolstrup, Janne

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N2 - Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study. Among variant allele carriers of ADH1C Arg(272)Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04-1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.

AB - Alcohol is a risk factor for breast cancer. We wanted to determine if ADH polymorphisms which modify the rate of ethanol oxidation to acetaldehyde, were associated with breast cancer risk. We matched 809 postmenopausal breast cancer cases with 809 controls, nested within the prospective Diet, Cancer and Health study. Among variant allele carriers of ADH1C Arg(272)Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04-1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk.

KW - Alcohol Dehydrogenase/genetics

KW - Alcohol Drinking/adverse effects

KW - Breast Neoplasms/etiology

KW - Ethanol/adverse effects

KW - Female

KW - Humans

KW - Middle Aged

KW - Polymorphism, Genetic

KW - Risk Factors

U2 - 10.1016/j.canlet.2010.02.023

DO - 10.1016/j.canlet.2010.02.023

M3 - Journal article

C2 - 20350778

VL - 295

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JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

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Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer

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