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Region Hovedstaden - en del af Københavns Universitetshospital
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Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

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  • Vamsi K Mootha
  • Jakob Bunkenborg
  • Jesper Velgaard Olsen
  • Majbrit Hjerrild
  • Jacek R Wisniewski
  • Erich Stahl
  • Marjan S Bolouri
  • Heta N Ray
  • Smita Sihag
  • Michael Kamal
  • Nick Patterson
  • Eric S Lander
  • Matthias Mann
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Mitochondria are tailored to meet the metabolic and signaling needs of each cell. To explore its molecular composition, we performed a proteomic survey of mitochondria from mouse brain, heart, kidney, and liver and combined the results with existing gene annotations to produce a list of 591 mitochondrial proteins, including 163 proteins not previously associated with this organelle. The protein expression data were largely concordant with large-scale surveys of RNA abundance and both measures indicate tissue-specific differences in organelle composition. RNA expression profiles across tissues revealed networks of mitochondrial genes that share functional and regulatory mechanisms. We also determined a larger "neighborhood" of genes whose expression is closely correlated to the mitochondrial genes. The combined analysis identifies specific genes of biological interest, such as candidates for mtDNA repair enzymes, offers new insights into the biogenesis and ancestry of mammalian mitochondria, and provides a framework for understanding the organelle's contribution to human disease.
OriginalsprogEngelsk
TidsskriftCell
Vol/bind115
Udgave nummer5
Sider (fra-til)629-40
Antal sider12
ISSN0092-8674
StatusUdgivet - 2003
Eksternt udgivetJa

ID: 42360061