Intake of ruminant trans fatty acids and risk of coronary heart disease

Marianne U Jakobsen; Kim Overvad; Jørn Dyerberg; Berit L Heitmann

doi:10.1093/ije/dym243

Intake of ruminant trans fatty acids and risk of coronary heart disease

Marianne U Jakobsen, Kim Overvad, Jørn Dyerberg, Berit L Heitmann

129 Citationer (Scopus)

Abstract

BACKGROUND: Studies have shown a positive association between trans fatty acids (TFA) intake and risk of coronary heart disease (CHD), primarily accounted for by industrially produced TFA. Some of these studies indicate an inverse association between ruminant TFA (R-TFA) intake and CHD implying that R-TFA intake is innocuous or even protective against CHD. The aim of this study was to describe the association between R-TFA intake and risk of CHD evaluating both the absolute and the energy-adjusted intake.

METHODS: The study was an 18-year follow-up study of 3686 Danes, aged 30-71 years, at baseline without previous CHD.

RESULTS: There were no overall associations between absolute or energy-adjusted R-TFA intakes and risk of CHD. However, among women, indications of inverse associations between R-TFA intake and risk of CHD were found: hazard ratio (HR) per 0.5 g increase in absolute R-TFA intake = 0.84 [95% confidence interval (CI): 0.70, 1.01] and HR per 0.5 g increase in energy-adjusted R-TFA intake = 0.77 (95% CI: 0.55, 1.09). No associations between absolute or energy-adjusted R-TFA intakes and CHD were found among men.

CONCLUSIONS: This study suggests that R-TFA intake is not associated with a higher risk of CHD. Whether R-TFA intake is even protective against CHD among women cannot be concluded from this study.

Originalsprog	Engelsk
Tidsskrift	International Journal of Epidemiology
Vol/bind	37
Udgave nummer	1
Sider (fra-til)	173-82
Antal sider	10
ISSN	0300-5771
DOI	https://doi.org/10.1093/ije/dym243
Status	Udgivet - feb. 2008

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10.1093/ije/dym243

Citationsformater

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title = "Intake of ruminant trans fatty acids and risk of coronary heart disease",

abstract = "BACKGROUND: Studies have shown a positive association between trans fatty acids (TFA) intake and risk of coronary heart disease (CHD), primarily accounted for by industrially produced TFA. Some of these studies indicate an inverse association between ruminant TFA (R-TFA) intake and CHD implying that R-TFA intake is innocuous or even protective against CHD. The aim of this study was to describe the association between R-TFA intake and risk of CHD evaluating both the absolute and the energy-adjusted intake.METHODS: The study was an 18-year follow-up study of 3686 Danes, aged 30-71 years, at baseline without previous CHD.RESULTS: There were no overall associations between absolute or energy-adjusted R-TFA intakes and risk of CHD. However, among women, indications of inverse associations between R-TFA intake and risk of CHD were found: hazard ratio (HR) per 0.5 g increase in absolute R-TFA intake = 0.84 [95% confidence interval (CI): 0.70, 1.01] and HR per 0.5 g increase in energy-adjusted R-TFA intake = 0.77 (95% CI: 0.55, 1.09). No associations between absolute or energy-adjusted R-TFA intakes and CHD were found among men.CONCLUSIONS: This study suggests that R-TFA intake is not associated with a higher risk of CHD. Whether R-TFA intake is even protective against CHD among women cannot be concluded from this study.",

keywords = "Adult, Age Distribution, Aged, Animals, Cohort Studies, Coronary Disease, Denmark, Dietary Fats, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Multivariate Analysis, Probability, Proportional Hazards Models, Prospective Studies, Risk Assessment, Ruminants, Sex Distribution, Time Factors, Trans Fatty Acids",

author = "Jakobsen, {Marianne U} and Kim Overvad and J{\o}rn Dyerberg and Heitmann, {Berit L}",

year = "2008",

month = feb,

doi = "10.1093/ije/dym243",

language = "English",

volume = "37",

pages = "173--82",

journal = "International Journal of Epidemiology",

issn = "0300-5771",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - Intake of ruminant trans fatty acids and risk of coronary heart disease

AU - Jakobsen, Marianne U

AU - Overvad, Kim

AU - Dyerberg, Jørn

AU - Heitmann, Berit L

PY - 2008/2

Y1 - 2008/2

N2 - BACKGROUND: Studies have shown a positive association between trans fatty acids (TFA) intake and risk of coronary heart disease (CHD), primarily accounted for by industrially produced TFA. Some of these studies indicate an inverse association between ruminant TFA (R-TFA) intake and CHD implying that R-TFA intake is innocuous or even protective against CHD. The aim of this study was to describe the association between R-TFA intake and risk of CHD evaluating both the absolute and the energy-adjusted intake.METHODS: The study was an 18-year follow-up study of 3686 Danes, aged 30-71 years, at baseline without previous CHD.RESULTS: There were no overall associations between absolute or energy-adjusted R-TFA intakes and risk of CHD. However, among women, indications of inverse associations between R-TFA intake and risk of CHD were found: hazard ratio (HR) per 0.5 g increase in absolute R-TFA intake = 0.84 [95% confidence interval (CI): 0.70, 1.01] and HR per 0.5 g increase in energy-adjusted R-TFA intake = 0.77 (95% CI: 0.55, 1.09). No associations between absolute or energy-adjusted R-TFA intakes and CHD were found among men.CONCLUSIONS: This study suggests that R-TFA intake is not associated with a higher risk of CHD. Whether R-TFA intake is even protective against CHD among women cannot be concluded from this study.

AB - BACKGROUND: Studies have shown a positive association between trans fatty acids (TFA) intake and risk of coronary heart disease (CHD), primarily accounted for by industrially produced TFA. Some of these studies indicate an inverse association between ruminant TFA (R-TFA) intake and CHD implying that R-TFA intake is innocuous or even protective against CHD. The aim of this study was to describe the association between R-TFA intake and risk of CHD evaluating both the absolute and the energy-adjusted intake.METHODS: The study was an 18-year follow-up study of 3686 Danes, aged 30-71 years, at baseline without previous CHD.RESULTS: There were no overall associations between absolute or energy-adjusted R-TFA intakes and risk of CHD. However, among women, indications of inverse associations between R-TFA intake and risk of CHD were found: hazard ratio (HR) per 0.5 g increase in absolute R-TFA intake = 0.84 [95% confidence interval (CI): 0.70, 1.01] and HR per 0.5 g increase in energy-adjusted R-TFA intake = 0.77 (95% CI: 0.55, 1.09). No associations between absolute or energy-adjusted R-TFA intakes and CHD were found among men.CONCLUSIONS: This study suggests that R-TFA intake is not associated with a higher risk of CHD. Whether R-TFA intake is even protective against CHD among women cannot be concluded from this study.

KW - Adult

KW - Age Distribution

KW - Aged

KW - Animals

KW - Cohort Studies

KW - Coronary Disease

KW - Denmark

KW - Dietary Fats

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Probability

KW - Proportional Hazards Models

KW - Prospective Studies

KW - Risk Assessment

KW - Ruminants

KW - Sex Distribution

KW - Time Factors

KW - Trans Fatty Acids

U2 - 10.1093/ije/dym243

DO - 10.1093/ije/dym243

M3 - Journal article

C2 - 18077475

SN - 0300-5771

VL - 37

SP - 173

EP - 182

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

IS - 1

ER -

Intake of ruminant trans fatty acids and risk of coronary heart disease

Abstract

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