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Insulin-like growth factor I and anthropometric parameters in a Danish population

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@article{0ee44c3b1dc348248eb31947ce73e0e7,
title = "Insulin-like growth factor I and anthropometric parameters in a Danish population",
abstract = "During the last decade several studies indicated that low insulin-like growth factor (IGF) I levels are related to higher risk of cardiovascular disease and mortality. Obesity represents one further main cardiovascular risk factor which might also be related to IGF-I. The objective of the present study was to analyse the associations between anthropometric measures and IGF-I levels in a population-based sample. From the Danish cross-sectional Health2006 study 3,328 subjects (1,835 women; 1,493 men) aged 19-72 years were included in the analyses. Serum IGF-I levels were determined by an immunoassay. Body height, weight as well as waist and hip circumferences were measured. Body-mass-index, waist-to-hip ratio and waist-to-height ratio were calculated. Circulating IGF-I levels were inversely associated with all anthropometric markers as evaluated by linear regression adjusting for age, alcohol consumption, smoking and physical activity. Our large cross-sectional study suggests that IGF-I may serve as the link between obesity and mortality although any causal relation cannot be inferred and longitudinal analyses are needed to clarify the causal relation.",
author = "N Friedrich and Torben J{\o}rgensen and A Juul and C Spielhagen and M Nauck and H Wallaschofski and Allan Linneberg",
note = "{\circledC} J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York.",
year = "2012",
doi = "10.1055/s-0031-1301289",
language = "English",
volume = "120",
pages = "171--4",
journal = "Experimental and Clinical Endocrinology and Diabetes",
issn = "0947-7349",
publisher = "Johann Ambrosius Barth Verlag in Medizinverlage Heidelberg GmbH & Co. KG",
number = "3",

}

RIS

TY - JOUR

T1 - Insulin-like growth factor I and anthropometric parameters in a Danish population

AU - Friedrich, N

AU - Jørgensen, Torben

AU - Juul, A

AU - Spielhagen, C

AU - Nauck, M

AU - Wallaschofski, H

AU - Linneberg, Allan

N1 - © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York.

PY - 2012

Y1 - 2012

N2 - During the last decade several studies indicated that low insulin-like growth factor (IGF) I levels are related to higher risk of cardiovascular disease and mortality. Obesity represents one further main cardiovascular risk factor which might also be related to IGF-I. The objective of the present study was to analyse the associations between anthropometric measures and IGF-I levels in a population-based sample. From the Danish cross-sectional Health2006 study 3,328 subjects (1,835 women; 1,493 men) aged 19-72 years were included in the analyses. Serum IGF-I levels were determined by an immunoassay. Body height, weight as well as waist and hip circumferences were measured. Body-mass-index, waist-to-hip ratio and waist-to-height ratio were calculated. Circulating IGF-I levels were inversely associated with all anthropometric markers as evaluated by linear regression adjusting for age, alcohol consumption, smoking and physical activity. Our large cross-sectional study suggests that IGF-I may serve as the link between obesity and mortality although any causal relation cannot be inferred and longitudinal analyses are needed to clarify the causal relation.

AB - During the last decade several studies indicated that low insulin-like growth factor (IGF) I levels are related to higher risk of cardiovascular disease and mortality. Obesity represents one further main cardiovascular risk factor which might also be related to IGF-I. The objective of the present study was to analyse the associations between anthropometric measures and IGF-I levels in a population-based sample. From the Danish cross-sectional Health2006 study 3,328 subjects (1,835 women; 1,493 men) aged 19-72 years were included in the analyses. Serum IGF-I levels were determined by an immunoassay. Body height, weight as well as waist and hip circumferences were measured. Body-mass-index, waist-to-hip ratio and waist-to-height ratio were calculated. Circulating IGF-I levels were inversely associated with all anthropometric markers as evaluated by linear regression adjusting for age, alcohol consumption, smoking and physical activity. Our large cross-sectional study suggests that IGF-I may serve as the link between obesity and mortality although any causal relation cannot be inferred and longitudinal analyses are needed to clarify the causal relation.

U2 - 10.1055/s-0031-1301289

DO - 10.1055/s-0031-1301289

M3 - Journal article

VL - 120

SP - 171

EP - 174

JO - Experimental and Clinical Endocrinology and Diabetes

JF - Experimental and Clinical Endocrinology and Diabetes

SN - 0947-7349

IS - 3

ER -

ID: 34845020