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Region Hovedstaden - en del af Københavns Universitetshospital
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Insulin-like growth factor 1 and growth hormone in chronic liver disease.

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Vis graf over relationer
Somatomedins or insulin-like growth factors (IGF) are peptides synthesized in the liver. IGFs have different anabolic and metabolic actions and are important in normal growth and development. The concentration of insulin-like growth factor 1 (IGF-1) is low in patients with chronic liver disease mainly due to the decreased liver function. Low levels of somatomedins are also seen in patients with growth hormone (GH) insufficiency, renal impairment, and malnutrition. GH stimulates the production of IGF-1, and both are part of a negative feedback system acting on hepatic, pituitary, and hypothalamic levels. The basal and stimulated GH concentration is pathologically elevated in patients with chronic liver disease and may be due to a disturbed regulation. Alterations in liver IGF receptors in patients with chronic liver disease still require investigation as they may be important for the liver function.
Bidragets oversatte titelInsulin-like growth factor 1 and growth hormone in chronic liver disease.
OriginalsprogEngelsk
TidsskriftDigestive Diseases
Vol/bind10
Udgave nummer4
Sider (fra-til)239-248
Antal sider10
ISSN0257-2753
StatusUdgivet - 1992

ID: 32542761