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Insulin resistance is associated with multiple chemical sensitivity in a danish population-based study—DanFunD

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Vis graf over relationer

Multiple chemical sensitivity (MCS) is a multisystem syndrome, and limited knowledge of its pathophysiology exists. Based on the population-based Danish cohort DanFunD, this study investigated metabolic health in people with MCS compared to individuals who did not have MCS. From 9656 cohort participants aged 18–76 years old, 1.95% were categorized as MCS individuals with comorbid functional somatic disorders (MCS + FSD, n = 188), and 1.13% were categorized as MCS without functional somatic disorders (MCS ÷ FSD, n = 109). MCS was characterized based on three criteria: the experience of symptoms upon exposure to common odors and airborne chemicals, symptoms related the central nervous systems and others organ symptoms, and significant impact on every day, social, and occupational life. The remaining study population without MCS or any other functional somatic disorders were regarded as controls. We used adjusted multiple linear regression with link-function to evaluate the associations between lipid and glucose metabolism markers and MCS. We also tested the odds ratio of metabolic syndrome in MCS. Results did not point to statistically significant associations between lipid biomarkers or metabolic syndrome and both MCS groups compared to the controls. We found that MCS individuals may be more insulin resistant and that MCS ÷ FSD may have an impaired glucose metabolism when compared to controls.

OriginalsprogEngelsk
Artikelnummer12654
TidsskriftInternational Journal of Environmental Research and Public Health
Vol/bind18
Udgave nummer23
ISSN1661-7827
DOI
StatusUdgivet - 30 nov. 2021

Bibliografisk note

Funding Information:
Funding: This research was funded by the Marilyn Hoffmann Foundation (grant #2021-1), the Tryg-fonden (7-11-0213), and the Lundbeck Foundation (R155-2013-14070). Cedeño-Laurent was funded by the Harvard Hoffman Program on Chemicals and Health.

Funding Information:
The authors would like to thank the participants in the DanFunD cohort and the staff behind the cohort at the Center for Clinical Research and Prevention, Bispebjerg & Frederiksberg Hospital, Capital Region of Denmark, for their work to collect and ensure high-quality data. The authors would also like to thank the Danish Study of Functional Disorders (DanFunD). The DanFunD scientific management group consists of Torben J?rgensen (principal investigator), Per Fink, Lene Falgaard Eplov, Susanne Brix Pedersen, Michael Benros, Allan Linneberg, and DanFunD scientific officer Thomas M Dantoft.This research was funded by the Marilyn Hoffmann Foundation (grant #2021-1), the Trygfonden (7-11-0213), and the Lundbeck Foundation (R155-2013-14070). Cede?o-Laurent was funded by the Harvard Hoffman Program on Chemicals and Health.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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