Insulin-like growth factors, insulin-like growth factor-binding proteins, insulin-like growth factor-binding protein-3 protease, and growth hormone-binding protein in lipodystrophic human immunodeficiency virus-infected patients

Steen B Haugaard; Ove Andersen; Birgitte R Hansen; Hans Orskov; Ulrik B Andersen; Sten Madsbad; Johan Iversen; Allan Flyvbjerg

Insulin-like growth factors, insulin-like growth factor-binding proteins, insulin-like growth factor-binding protein-3 protease, and growth hormone-binding protein in lipodystrophic human immunodeficiency virus-infected patients

Steen B Haugaard, Ove Andersen, Birgitte R Hansen, Hans Orskov, Ulrik B Andersen, Sten Madsbad, Johan Iversen, Allan Flyvbjerg

13 Citationer (Scopus)

Abstract

Udgivelsesdato: 2004-Dec

Originalsprog	Engelsk
Tidsskrift	Metabolism
Vol/bind	53
Udgave nummer	12
Sider (fra-til)	1565-73
Antal sider	8
ISSN	0026-0495
Status	Udgivet - 2004

Adgang til dokumentet

https://www.sciencedirect.com/science/article/abs/pii/S002604950400280X?via%3Dihub

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Citationsformater

Haugaard, S. B., Andersen, O., Hansen, B. R., Orskov, H., Andersen, U. B., Madsbad, S., Iversen, J., & Flyvbjerg, A. (2004). Insulin-like growth factors, insulin-like growth factor-binding proteins, insulin-like growth factor-binding protein-3 protease, and growth hormone-binding protein in lipodystrophic human immunodeficiency virus-infected patients. Metabolism, 53(12), 1565-73. https://www.sciencedirect.com/science/article/abs/pii/S002604950400280X?via%3Dihub

Insulin-like growth factors, insulin-like growth factor-binding proteins, insulin-like growth factor-binding protein-3 protease, and growth hormone-binding protein in lipodystrophic human immunodeficiency virus-infected patients. / Haugaard, Steen B ; Andersen, Ove ; Hansen, Birgitte R et al.
I: Metabolism, Bind 53, Nr. 12, 2004, s. 1565-73.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Haugaard, SB , Andersen, O , Hansen, BR, Orskov, H, Andersen, UB, Madsbad, S, Iversen, J & Flyvbjerg, A 2004, 'Insulin-like growth factors, insulin-like growth factor-binding proteins, insulin-like growth factor-binding protein-3 protease, and growth hormone-binding protein in lipodystrophic human immunodeficiency virus-infected patients', Metabolism, bind 53, nr. 12, s. 1565-73. <https://www.sciencedirect.com/science/article/abs/pii/S002604950400280X?via%3Dihub>

@article{165dfe82a3c34a2c9563413bb58a4ad1,

title = "Insulin-like growth factors, insulin-like growth factor-binding proteins, insulin-like growth factor-binding protein-3 protease, and growth hormone-binding protein in lipodystrophic human immunodeficiency virus-infected patients",

abstract = "Human immunodeficiency virus (HIV)-lipodystrophy is associated with impaired growth hormone (GH) secretion. It remains to be elucidated whether insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), IGFBP-3 protease, and GH-binding protein (GHBP) are abnormal in HIV-lipodystrophy. These parameters were measured in overnight fasting serum samples from 16 Caucasian males with HIV-lipodystrophy (LIPO) and 15 Caucasian HIV-infected males without lipodystrophy (NONLIPO) matched for age, weight, duration of HIV infection, and antiretroviral therapy. In LIPO, abdominal fat mass and insulin concentration were increased (>90%, P < .01) and insulin sensitivity (Log10ISI(composite)) was decreased (-50%, P < .001). Total and free IGF-I, IGF-II, IGFBP-3, and IGFBP-3 protease were similar between groups (all P > .5), whereas, in LIPO, IGFBP-1 and IGFBP-2 were reduced (-36%, P < .05 and -50%, P < .01). In pooled groups, total IGF-I, free IGF-I, total IGF-II, and IGFBP-3, respectively, correlated inversely with age (all P < .01). In pooled groups, IGFBP-1 and IGFBP-2 correlated positively with insulin sensitivity (age-adjusted all P < .05). IGFBP-3 protease correlated with free IGF-I in pooled groups (r(p) = 0.47, P < .02), and in LIPO (r(p) = 0.71, P < .007) controlling for age, total IGF-I, and IGFBP-3. GHBP was increased, whereas GH was decreased in LIPO (all P < .05). GH correlated inversely with GHBP in pooled groups (P < .05). Taken together the similar IGFs and IGFBP-3 concentrations between study groups, including suppressed GH, and increased GHBP in LIPO, argue against GH resistance of GH-sensitive tissues in LIPO compared with NONLIPO; however, this notion awaits examination in dose-response studies. Furthermore, our data suggest that IGFBP-3 protease is a significant regulator of bioactive IGF-I in HIV-lipodystrophy.",

keywords = "Age Factors, Blood Glucose, Body Composition, Body Constitution, Body Mass Index, C-Peptide, Carrier Proteins, Endopeptidases, HIV Infections, Humans, Insulin, Insulin-Like Growth Factor Binding Proteins, Linear Models, Lipodystrophy, Male, Middle Aged, Somatomedins",

author = "Haugaard, {Steen B} and Ove Andersen and Hansen, {Birgitte R} and Hans Orskov and Andersen, {Ulrik B} and Sten Madsbad and Johan Iversen and Allan Flyvbjerg",

year = "2004",

language = "English",

volume = "53",

pages = "1565--73",

journal = "Metabolism",

issn = "0026-0495",

publisher = "W.B./Saunders Co",

number = "12",

}

TY - JOUR

T1 - Insulin-like growth factors, insulin-like growth factor-binding proteins, insulin-like growth factor-binding protein-3 protease, and growth hormone-binding protein in lipodystrophic human immunodeficiency virus-infected patients

AU - Haugaard, Steen B

AU - Andersen, Ove

AU - Hansen, Birgitte R

AU - Orskov, Hans

AU - Andersen, Ulrik B

AU - Madsbad, Sten

AU - Iversen, Johan

AU - Flyvbjerg, Allan

PY - 2004

Y1 - 2004

N2 - Human immunodeficiency virus (HIV)-lipodystrophy is associated with impaired growth hormone (GH) secretion. It remains to be elucidated whether insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), IGFBP-3 protease, and GH-binding protein (GHBP) are abnormal in HIV-lipodystrophy. These parameters were measured in overnight fasting serum samples from 16 Caucasian males with HIV-lipodystrophy (LIPO) and 15 Caucasian HIV-infected males without lipodystrophy (NONLIPO) matched for age, weight, duration of HIV infection, and antiretroviral therapy. In LIPO, abdominal fat mass and insulin concentration were increased (>90%, P < .01) and insulin sensitivity (Log10ISI(composite)) was decreased (-50%, P < .001). Total and free IGF-I, IGF-II, IGFBP-3, and IGFBP-3 protease were similar between groups (all P > .5), whereas, in LIPO, IGFBP-1 and IGFBP-2 were reduced (-36%, P < .05 and -50%, P < .01). In pooled groups, total IGF-I, free IGF-I, total IGF-II, and IGFBP-3, respectively, correlated inversely with age (all P < .01). In pooled groups, IGFBP-1 and IGFBP-2 correlated positively with insulin sensitivity (age-adjusted all P < .05). IGFBP-3 protease correlated with free IGF-I in pooled groups (r(p) = 0.47, P < .02), and in LIPO (r(p) = 0.71, P < .007) controlling for age, total IGF-I, and IGFBP-3. GHBP was increased, whereas GH was decreased in LIPO (all P < .05). GH correlated inversely with GHBP in pooled groups (P < .05). Taken together the similar IGFs and IGFBP-3 concentrations between study groups, including suppressed GH, and increased GHBP in LIPO, argue against GH resistance of GH-sensitive tissues in LIPO compared with NONLIPO; however, this notion awaits examination in dose-response studies. Furthermore, our data suggest that IGFBP-3 protease is a significant regulator of bioactive IGF-I in HIV-lipodystrophy.

AB - Human immunodeficiency virus (HIV)-lipodystrophy is associated with impaired growth hormone (GH) secretion. It remains to be elucidated whether insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), IGFBP-3 protease, and GH-binding protein (GHBP) are abnormal in HIV-lipodystrophy. These parameters were measured in overnight fasting serum samples from 16 Caucasian males with HIV-lipodystrophy (LIPO) and 15 Caucasian HIV-infected males without lipodystrophy (NONLIPO) matched for age, weight, duration of HIV infection, and antiretroviral therapy. In LIPO, abdominal fat mass and insulin concentration were increased (>90%, P < .01) and insulin sensitivity (Log10ISI(composite)) was decreased (-50%, P < .001). Total and free IGF-I, IGF-II, IGFBP-3, and IGFBP-3 protease were similar between groups (all P > .5), whereas, in LIPO, IGFBP-1 and IGFBP-2 were reduced (-36%, P < .05 and -50%, P < .01). In pooled groups, total IGF-I, free IGF-I, total IGF-II, and IGFBP-3, respectively, correlated inversely with age (all P < .01). In pooled groups, IGFBP-1 and IGFBP-2 correlated positively with insulin sensitivity (age-adjusted all P < .05). IGFBP-3 protease correlated with free IGF-I in pooled groups (r(p) = 0.47, P < .02), and in LIPO (r(p) = 0.71, P < .007) controlling for age, total IGF-I, and IGFBP-3. GHBP was increased, whereas GH was decreased in LIPO (all P < .05). GH correlated inversely with GHBP in pooled groups (P < .05). Taken together the similar IGFs and IGFBP-3 concentrations between study groups, including suppressed GH, and increased GHBP in LIPO, argue against GH resistance of GH-sensitive tissues in LIPO compared with NONLIPO; however, this notion awaits examination in dose-response studies. Furthermore, our data suggest that IGFBP-3 protease is a significant regulator of bioactive IGF-I in HIV-lipodystrophy.

KW - Age Factors

KW - Blood Glucose

KW - Body Composition

KW - Body Constitution

KW - Body Mass Index

KW - C-Peptide

KW - Carrier Proteins

KW - Endopeptidases

KW - HIV Infections

KW - Humans

KW - Insulin

KW - Insulin-Like Growth Factor Binding Proteins

KW - Linear Models

KW - Lipodystrophy

KW - Male

KW - Middle Aged

KW - Somatomedins

M3 - Journal article

C2 - 15562401

SN - 0026-0495

VL - 53

SP - 1565

EP - 1573

JO - Metabolism

JF - Metabolism

IS - 12

ER -