Insulin-like growth factor I receptor density on CD4+T-lymphocytes from active early steroid- and DMARD-naïve rheumatoid arthritis patients is up-regulated and not influenced by 1 year of clinically effective treatment

Trine Bay Laurberg, Torkell Juulsgaad Ellingsen, Jonas Thorsen, Bjarne Kuno Møller, Ib Tønder Hansen, Ulrik Tarp, Merete Lund Hetland, Kim Hørslev-Petersen, Allan Flyvbjerg, Jan Frystyk, Kristian Stengaard-Pedersen

    8 Citationer (Scopus)

    Abstract

    The IGF-IR density on CD4+T-lymphocytes was studied using flow cytometry in 40 early steroid- and DMARD-naïve rheumatoid arthritis (RA) patients before and after 52 weeks of treatment with methotrexate+placebo or methotrexate+cyclosporine A and in 15 controls. RA patients had increased IGF-IR density on CD4+T-lymphocytes at week 0 and week 52, irrespective of treatment. IGF-IR-positive CD4+T-lymphocytes fraction decreased during treatment, but neither at week 0 nor at week 52 did it differ from healthy controls. No correlations were found to disease activity parameters.
    OriginalsprogEngelsk
    TidsskriftRheumatology International
    Vol/bind32
    Udgave nummer2
    Sider (fra-til)501-4
    Antal sider4
    ISSN0172-8172
    DOI
    StatusUdgivet - 2012

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