Abstract
OBJECTIVE: To examine vaginal insulin-like growth factor binding protein 1 (IGFBP-1) as a marker of preterm delivery, amniotic fluid leakage or vaginal infection.
MATERIALS AND METHODS: The material consisted of a nested case-control study (67 with idiopathic preterm delivery and 406 randomly selected women with term deliveries) from a prospective cohort of 2,846 women.
RESULTS: Vaginal npIGFBP-1 was weakly associated with preterm delivery. Elevated npIGFBP-1 gave an increased risk of preterm delivery (OR 2.8 [1.4-6. 7]). Elevated IGFBP-1 provided a sensitivity of 13% at a false-positive rate of 4.4% in a low-risk population. When adjusting for other covariates associated with preterm delivery the association between npIGFBP-1 and preterm delivery disappeared; there was an interaction between alcohol consumption and npIGFBP-1.
CONCLUSION: The current study found vaginal npIGFBP-1 to be weakly associated with gestational age at delivery. However, in this study the association may potentially be explained by alcohol consumption.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | In vivo (Athens, Greece) |
| Vol/bind | 18 |
| Udgave nummer | 1 |
| Sider (fra-til) | 37-41 |
| Antal sider | 5 |
| ISSN | 0258-851X |
| Status | Udgivet - 12 mar. 2004 |
| Udgivet eksternt | Ja |