Insulin facilitates transport of macromolecules and nutrients to muscles

N J Christensen, J Hilsted

    2 Citationer (Scopus)

    Abstract

    We previously showed that intravenous insulin increased plasma noradrenaline during euglycemia and without concomitant changes in plasma adrenaline. Insulin decreased plasma volume and increased the fractional escape rate of albumin from plasma. In normal subjects, oral glucose increased heart rate, systolic blood pressure and plasma noradrenaline. These changes were absent or attenuated in diabetic patients (without neuropathy) after an oral glucose load. These responses were normalized by insulin infusion. Our results suggest that insulin facilitates the transfer of macromolecules and nutrients from the blood to the extracellular space after food intake. This process may be greatly disturbed in insulin-dependent diabetic patients.
    OriginalsprogEngelsk
    TidsskriftInternational Journal of Obesity
    Vol/bind17 Suppl 3
    Sider (fra-til)S83-5; discussion S97
    ISSN0307-0565
    StatusUdgivet - dec. 1993

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