Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players

Stefania Orrù; Esther Imperlini; Daniela Vitucci; Marianna Caterino; Annalisa Mandola; Morten Bredsgaard Randers; Jakob Friis Schmidt; Marie Hagman; Thomas Rostgaard Andersen; Peter Krustrup; Margherita Ruoppolo; Pasqualina Buono; Annamaria Mancini

doi:10.3390/ijerph192315835

Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players

Stefania Orrù, Esther Imperlini, Daniela Vitucci, Marianna Caterino, Annalisa Mandola, Morten Bredsgaard Randers, Jakob Friis Schmidt, Marie Hagman, Thomas Rostgaard Andersen, Peter Krustrup, Margherita Ruoppolo, Pasqualina Buono^*, Annamaria Mancini

^*Corresponding author af dette arbejde

Afdeling for Bedøvelse, Operation og TraumeCenter HOC

6 Citationer (Scopus)

Abstract

BACKGROUND: Aging and sedentary behavior are independent risk factors for non-communicable diseases. An active lifestyle and structured physical activity are positively associated with a healthier quality of life in the elderly. Here, we explored the proteomic/metabolomic muscular signature induced by lifelong football training associated with successful aging.

METHODS: The study was performed on nine lifelong football players (67.3 ± 2.8 yrs) and nine aged-matched untrained subjects. We performed a proteomic/metabolomic approach on V. lateralis muscle biopsies; the obtained data were analyzed by means of different bioinformatic tools.

RESULTS: Our results indicated that lifelong football training is able to enhance the muscles' oxidative capacity in the elderly by promoting fatty acids as preferential energetic substrates and hence determining a healthier body composition and metabolic profile; furthermore, we showed that the total polyamine content is higher in lifelong football players' muscle, enforcing the involvement of polyamines in muscle growth and hypertrophy.

CONCLUSIONS: Lifelong football training, as a structured physical activity, significantly influences the expression of the proteins and metabolites involved in oxidative metabolism and muscle hypertrophy associated with successful aging.

Originalsprog	Engelsk
Artikelnummer	15835
Tidsskrift	International Journal of Environmental Research and Public Health
Vol/bind	19
Udgave nummer	23
ISSN	1661-7827
DOI	https://doi.org/10.3390/ijerph192315835
Status	Udgivet - 28 nov. 2022

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10.3390/ijerph192315835

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Orrù, S., Imperlini, E., Vitucci, D., Caterino, M., Mandola, A., Randers, M. B., Schmidt, J. F., Hagman, M., Andersen, T. R., Krustrup, P., Ruoppolo, M., Buono, P., & Mancini, A. (2022). Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players. International Journal of Environmental Research and Public Health, 19(23), Artikel 15835. https://doi.org/10.3390/ijerph192315835

Orrù, S, Imperlini, E, Vitucci, D, Caterino, M, Mandola, A, Randers, MB, Schmidt, JF, Hagman, M, Andersen, TR, Krustrup, P, Ruoppolo, M, Buono, P & Mancini, A 2022, 'Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players', International Journal of Environmental Research and Public Health, bind 19, nr. 23, 15835. https://doi.org/10.3390/ijerph192315835

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title = "Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players",

abstract = "BACKGROUND: Aging and sedentary behavior are independent risk factors for non-communicable diseases. An active lifestyle and structured physical activity are positively associated with a healthier quality of life in the elderly. Here, we explored the proteomic/metabolomic muscular signature induced by lifelong football training associated with successful aging.METHODS: The study was performed on nine lifelong football players (67.3 ± 2.8 yrs) and nine aged-matched untrained subjects. We performed a proteomic/metabolomic approach on V. lateralis muscle biopsies; the obtained data were analyzed by means of different bioinformatic tools.RESULTS: Our results indicated that lifelong football training is able to enhance the muscles' oxidative capacity in the elderly by promoting fatty acids as preferential energetic substrates and hence determining a healthier body composition and metabolic profile; furthermore, we showed that the total polyamine content is higher in lifelong football players' muscle, enforcing the involvement of polyamines in muscle growth and hypertrophy.CONCLUSIONS: Lifelong football training, as a structured physical activity, significantly influences the expression of the proteins and metabolites involved in oxidative metabolism and muscle hypertrophy associated with successful aging.",

keywords = "lifelong football training, mitochondrial oxidative capacity, polyamines, successful aging",

author = "Stefania Orr{\`u} and Esther Imperlini and Daniela Vitucci and Marianna Caterino and Annalisa Mandola and Randers, \{Morten Bredsgaard\} and Schmidt, \{Jakob Friis\} and Marie Hagman and Andersen, \{Thomas Rostgaard\} and Peter Krustrup and Margherita Ruoppolo and Pasqualina Buono and Annamaria Mancini",

year = "2022",

month = nov,

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doi = "10.3390/ijerph192315835",

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journal = "International Journal of Environmental Research and Public Health",

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T1 - Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players

AU - Orrù, Stefania

AU - Imperlini, Esther

AU - Vitucci, Daniela

AU - Caterino, Marianna

AU - Mandola, Annalisa

AU - Randers, Morten Bredsgaard

AU - Schmidt, Jakob Friis

AU - Hagman, Marie

AU - Andersen, Thomas Rostgaard

AU - Krustrup, Peter

AU - Ruoppolo, Margherita

AU - Buono, Pasqualina

AU - Mancini, Annamaria

PY - 2022/11/28

Y1 - 2022/11/28

N2 - BACKGROUND: Aging and sedentary behavior are independent risk factors for non-communicable diseases. An active lifestyle and structured physical activity are positively associated with a healthier quality of life in the elderly. Here, we explored the proteomic/metabolomic muscular signature induced by lifelong football training associated with successful aging.METHODS: The study was performed on nine lifelong football players (67.3 ± 2.8 yrs) and nine aged-matched untrained subjects. We performed a proteomic/metabolomic approach on V. lateralis muscle biopsies; the obtained data were analyzed by means of different bioinformatic tools.RESULTS: Our results indicated that lifelong football training is able to enhance the muscles' oxidative capacity in the elderly by promoting fatty acids as preferential energetic substrates and hence determining a healthier body composition and metabolic profile; furthermore, we showed that the total polyamine content is higher in lifelong football players' muscle, enforcing the involvement of polyamines in muscle growth and hypertrophy.CONCLUSIONS: Lifelong football training, as a structured physical activity, significantly influences the expression of the proteins and metabolites involved in oxidative metabolism and muscle hypertrophy associated with successful aging.

AB - BACKGROUND: Aging and sedentary behavior are independent risk factors for non-communicable diseases. An active lifestyle and structured physical activity are positively associated with a healthier quality of life in the elderly. Here, we explored the proteomic/metabolomic muscular signature induced by lifelong football training associated with successful aging.METHODS: The study was performed on nine lifelong football players (67.3 ± 2.8 yrs) and nine aged-matched untrained subjects. We performed a proteomic/metabolomic approach on V. lateralis muscle biopsies; the obtained data were analyzed by means of different bioinformatic tools.RESULTS: Our results indicated that lifelong football training is able to enhance the muscles' oxidative capacity in the elderly by promoting fatty acids as preferential energetic substrates and hence determining a healthier body composition and metabolic profile; furthermore, we showed that the total polyamine content is higher in lifelong football players' muscle, enforcing the involvement of polyamines in muscle growth and hypertrophy.CONCLUSIONS: Lifelong football training, as a structured physical activity, significantly influences the expression of the proteins and metabolites involved in oxidative metabolism and muscle hypertrophy associated with successful aging.

KW - lifelong football training

KW - mitochondrial oxidative capacity

KW - polyamines

KW - successful aging

UR - https://www.scopus.com/pages/publications/85143736122

U2 - 10.3390/ijerph192315835

DO - 10.3390/ijerph192315835

M3 - Journal article

C2 - 36497910

SN - 1661-7827

VL - 19

JO - International Journal of Environmental Research and Public Health

JF - International Journal of Environmental Research and Public Health

IS - 23

M1 - 15835

ER -

Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players

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