Inhibitors of topoisomerase II as pH-dependent modulators of etoposide-mediated cytotoxicity

Keyphrases

• Cytotoxicity 100%
• Topoisomerase II 100%
• Etoposide 100%
• PH Dependence 100%
• Chloroquine 85%
• Acridine 42%
• Solid Tumors 28%
• Topoisomerase II Poison 28%
• Clonogenic Assay 28%
• Side Arm 28%
• Drug Interactions 14%
• Therapeutic Index 14%
• Extracellular Volume 14%
• Target Enzyme 14%
• Poisoning 14%
• Structure-activity Relationship 14%
• Intracellular Accumulation 14%
• Extracellular pH 14%
• Enzyme Inhibition 14%
• Hydroxychloroquine 14%
• Protector 14%
• Cellular Transport 14%
• Quinacrine 14%
• Cleavage Reactions 14%
• DNA Cleavage 14%
• Chloroquine Analogs 14%
• 9-Aminoacridine 14%
• Weak Base 14%
• Transport Measurements 14%

Pharmacology, Toxicology and Pharmaceutical Science

• DNA Topoisomerase (ATP Hydrolysing) 100%
• Cytotoxicity 100%
• Etoposide 100%
• Chloroquine 100%
• Solid Malignant Neoplasm 28%
• Acridine Derivative 28%
• Toxic Injury 14%
• Drug Interaction 14%
• Therapeutic Window 14%
• Base 14%
• Structure Activity Relationship 14%
• Enzyme Inhibition 14%
• Hydroxychloroquine 14%
• Acridine 14%
• Mepacrine 14%
• Aminoacridine 14%

Chemistry

• Chloroquine 100%
• Etoposide 100%
• Acridine 42%
• Deoxyribonucleic Acid 28%
• Clonogenic 28%
• Base 14%
• Toxic 14%
• Structure-Activity Relationship 14%
• Hydroxychloroquine 14%
• Enzyme Inhibition 14%
• Quinacrine 14%
• 9-Aminoacridine 14%