Inhibition of Natural Killer Cell Activity by Antigen‐Antibody Complexes

B. K. Pedersen; B. S. Thomsen; H. Nielsen

doi:10.1111/j.1398-9995.1986.tb00348.x

Inhibition of Natural Killer Cell Activity by Antigen‐Antibody Complexes

B. K. Pedersen^*, B. S. Thomsen, H. Nielsen

^*Corresponding author af dette arbejde

16 Citationer (Scopus)

Abstract

The natural killer (NK) cell activity of human peripheral blood mononuclear cells was found to be inhibited by precipitated tetanus toxoid anti‐tetanus toxoid complexes (Te/ aTe) as well as soluble Te/aTe, Preincubation of the immune complexes with protein A decreased the inhibition of NK cell activity. When mononuclear cells were preincubated with interferon (IF) or interleukin 2 (II‐2) before incubation with Te/aTe, the immune complex‐induced inhibition was decreased, while IF or II‐2 added after incubation with the immune complexes had no effect. Using NK cell‐enriched suspensions in a single cell agarose assay, the immune complexes were shown to inhibit NK cell activity by inhibiting the formation of effector/target cell conjugates.

Originalsprog	Engelsk
Tidsskrift	Allergy
Vol/bind	41
Udgave nummer	8
Sider (fra-til)	568-574
Antal sider	7
ISSN	0105-4538
DOI	https://doi.org/10.1111/j.1398-9995.1986.tb00348.x
Status	Udgivet - nov. 1986
Udgivet eksternt	Ja

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10.1111/j.1398-9995.1986.tb00348.x

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title = "Inhibition of Natural Killer Cell Activity by Antigen‐Antibody Complexes",

abstract = "The natural killer (NK) cell activity of human peripheral blood mononuclear cells was found to be inhibited by precipitated tetanus toxoid anti‐tetanus toxoid complexes (Te/ aTe) as well as soluble Te/aTe, Preincubation of the immune complexes with protein A decreased the inhibition of NK cell activity. When mononuclear cells were preincubated with interferon (IF) or interleukin 2 (II‐2) before incubation with Te/aTe, the immune complex‐induced inhibition was decreased, while IF or II‐2 added after incubation with the immune complexes had no effect. Using NK cell‐enriched suspensions in a single cell agarose assay, the immune complexes were shown to inhibit NK cell activity by inhibiting the formation of effector/target cell conjugates.",

keywords = "Fc‐receptor, immune complexes, natural killer cells",

author = "Pedersen, {B. K.} and Thomsen, {B. S.} and H. Nielsen",

year = "1986",

month = nov,

doi = "10.1111/j.1398-9995.1986.tb00348.x",

language = "English",

volume = "41",

pages = "568--574",

journal = "Allergy",

issn = "0105-4538",

publisher = "Wiley-Blackwell Publishing Ltd",

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TY - JOUR

T1 - Inhibition of Natural Killer Cell Activity by Antigen‐Antibody Complexes

AU - Pedersen, B. K.

AU - Thomsen, B. S.

AU - Nielsen, H.

PY - 1986/11

Y1 - 1986/11

N2 - The natural killer (NK) cell activity of human peripheral blood mononuclear cells was found to be inhibited by precipitated tetanus toxoid anti‐tetanus toxoid complexes (Te/ aTe) as well as soluble Te/aTe, Preincubation of the immune complexes with protein A decreased the inhibition of NK cell activity. When mononuclear cells were preincubated with interferon (IF) or interleukin 2 (II‐2) before incubation with Te/aTe, the immune complex‐induced inhibition was decreased, while IF or II‐2 added after incubation with the immune complexes had no effect. Using NK cell‐enriched suspensions in a single cell agarose assay, the immune complexes were shown to inhibit NK cell activity by inhibiting the formation of effector/target cell conjugates.

AB - The natural killer (NK) cell activity of human peripheral blood mononuclear cells was found to be inhibited by precipitated tetanus toxoid anti‐tetanus toxoid complexes (Te/ aTe) as well as soluble Te/aTe, Preincubation of the immune complexes with protein A decreased the inhibition of NK cell activity. When mononuclear cells were preincubated with interferon (IF) or interleukin 2 (II‐2) before incubation with Te/aTe, the immune complex‐induced inhibition was decreased, while IF or II‐2 added after incubation with the immune complexes had no effect. Using NK cell‐enriched suspensions in a single cell agarose assay, the immune complexes were shown to inhibit NK cell activity by inhibiting the formation of effector/target cell conjugates.

KW - Fc‐receptor

KW - immune complexes

KW - natural killer cells

UR - http://www.scopus.com/inward/record.url?scp=0022971402&partnerID=8YFLogxK

U2 - 10.1111/j.1398-9995.1986.tb00348.x

DO - 10.1111/j.1398-9995.1986.tb00348.x

M3 - Journal article

C2 - 3492939

AN - SCOPUS:0022971402

SN - 0105-4538

VL - 41

SP - 568

EP - 574

JO - Allergy

JF - Allergy

IS - 8

ER -

Inhibition of Natural Killer Cell Activity by Antigen‐Antibody Complexes

Abstract

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