Influence of reported study design characteristics on intervention effect estimates from randomised controlled trials: combined analysis of meta-epidemiological studies

J Savović; He Jones; Dg Altman; Rj Harris; P Jűni; Julie Pildal; B Als-Nielsen; Em Balk; C Gluud; Lise Lotte Gluud; Jpa Ioannidis; Kf Schulz; R Beynon; N Welton; L Wood; D Moher; Jj Deeks; Jac Sterne

doi:10.3310/hta16350

Influence of reported study design characteristics on intervention effect estimates from randomised controlled trials: combined analysis of meta-epidemiological studies

J Savović, He Jones, Dg Altman, Rj Harris, P Jűni, Julie Pildal, B Als-Nielsen, Em Balk, C Gluud, Lise Lotte Gluud, Jpa Ioannidis, Kf Schulz, R Beynon, N Welton, L Wood, D Moher, Jj Deeks, Jac Sterne

561 Citationer (Scopus)

Abstract

The design of randomised controlled trials (RCTs) should incorporate characteristics (such as concealment of randomised allocation and blinding of participants and personnel) that avoid biases resulting from lack of comparability of the intervention and control groups. Empirical evidence suggests that the absence of such characteristics leads to biased intervention effect estimates, but the findings of different studies are not consistent.

Originalsprog	Engelsk
Bogserie	Health Technology Assessment
Vol/bind	16
Udgave nummer	35
Sider (fra-til)	1-82
Antal sider	82
ISSN	1366-5278
DOI	https://doi.org/10.3310/hta16350
Status	Udgivet - 2012

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10.3310/hta16350

Citationsformater

Savović, J., Jones, H., Altman, D., Harris, R., Jűni, P., Pildal, J., Als-Nielsen, B., Balk, E., Gluud, C., Gluud, L. L., Ioannidis, J., Schulz, K., Beynon, R., Welton, N., Wood, L., Moher, D., Deeks, J., & Sterne, J. (2012). Influence of reported study design characteristics on intervention effect estimates from randomised controlled trials: combined analysis of meta-epidemiological studies. Health Technology Assessment, 16(35), 1-82. https://doi.org/10.3310/hta16350

Savović, J, Jones, H, Altman, D, Harris, R, Jűni, P, Pildal, J, Als-Nielsen, B, Balk, E, Gluud, C , Gluud, LL, Ioannidis, J, Schulz, K, Beynon, R, Welton, N, Wood, L, Moher, D, Deeks, J & Sterne, J 2012, 'Influence of reported study design characteristics on intervention effect estimates from randomised controlled trials: combined analysis of meta-epidemiological studies', Health Technology Assessment, bind 16, nr. 35, s. 1-82. https://doi.org/10.3310/hta16350

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abstract = "The design of randomised controlled trials (RCTs) should incorporate characteristics (such as concealment of randomised allocation and blinding of participants and personnel) that avoid biases resulting from lack of comparability of the intervention and control groups. Empirical evidence suggests that the absence of such characteristics leads to biased intervention effect estimates, but the findings of different studies are not consistent.",

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AU - Jűni, P

AU - Pildal, Julie

AU - Als-Nielsen, B

AU - Balk, Em

AU - Gluud, C

AU - Gluud, Lise Lotte

AU - Ioannidis, Jpa

AU - Schulz, Kf

AU - Beynon, R

AU - Welton, N

AU - Wood, L

AU - Moher, D

AU - Deeks, Jj

AU - Sterne, Jac

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AB - The design of randomised controlled trials (RCTs) should incorporate characteristics (such as concealment of randomised allocation and blinding of participants and personnel) that avoid biases resulting from lack of comparability of the intervention and control groups. Empirical evidence suggests that the absence of such characteristics leads to biased intervention effect estimates, but the findings of different studies are not consistent.

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DO - 10.3310/hta16350

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Influence of reported study design characteristics on intervention effect estimates from randomised controlled trials: combined analysis of meta-epidemiological studies

Abstract

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