Influence of prednisolone on antipyrine elimination in patients with obstructive lung disease

S Loft; K Simonsen; T Evald; H R Christensen; J Sonne; M Døssing

doi:10.1007/BF00610387

Influence of prednisolone on antipyrine elimination in patients with obstructive lung disease

S Loft, K Simonsen, T Evald, H R Christensen, J Sonne, M Døssing

Abstract

The influence of prednisolone on the elimination of antipyrine has been investigated. The one-sample antipyrine clearance was estimated in 23 outpatients with obstructive lung disease before and after treatment with prednisolone 30 or 50 mg/day for 7 days. During prednisolone administration antipyrine clearance decreased from 54.9 +/- 14.8 to 51.7 +/- 14.6 ml/min (mean +/- SD; p less than 0.05). The results indicate that prednisolone decreases the rate of antipyrine elimination, but not to an extent suggesting a clinically important change in hepatic drug metabolism.

Originalsprog	Engelsk
Tidsskrift	European Journal of Clinical Pharmacology
Vol/bind	33
Udgave nummer	1
Sider (fra-til)	89-91
Antal sider	3
ISSN	0031-6970
DOI	https://doi.org/10.1007/BF00610387
Status	Udgivet - 1987

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10.1007/BF00610387

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@article{2248597540d248be93225b9078fd3842,

title = "Influence of prednisolone on antipyrine elimination in patients with obstructive lung disease",

abstract = "The influence of prednisolone on the elimination of antipyrine has been investigated. The one-sample antipyrine clearance was estimated in 23 outpatients with obstructive lung disease before and after treatment with prednisolone 30 or 50 mg/day for 7 days. During prednisolone administration antipyrine clearance decreased from 54.9 +/- 14.8 to 51.7 +/- 14.6 ml/min (mean +/- SD; p less than 0.05). The results indicate that prednisolone decreases the rate of antipyrine elimination, but not to an extent suggesting a clinically important change in hepatic drug metabolism.",

keywords = "Antipyrine/pharmacokinetics, Female, Humans, Liver/drug effects, Lung Diseases, Obstructive/metabolism, Male, Metabolic Clearance Rate, Middle Aged, Prednisolone/pharmacology",

author = "S Loft and K Simonsen and T Evald and Christensen, {H R} and J Sonne and M D{\o}ssing",

year = "1987",

doi = "10.1007/BF00610387",

language = "English",

volume = "33",

pages = "89--91",

journal = "European Journal of Clinical Pharmacology",

issn = "0031-6970",

publisher = "Springer",

number = "1",

}

TY - JOUR

T1 - Influence of prednisolone on antipyrine elimination in patients with obstructive lung disease

AU - Loft, S

AU - Simonsen, K

AU - Evald, T

AU - Christensen, H R

AU - Sonne, J

AU - Døssing, M

PY - 1987

Y1 - 1987

N2 - The influence of prednisolone on the elimination of antipyrine has been investigated. The one-sample antipyrine clearance was estimated in 23 outpatients with obstructive lung disease before and after treatment with prednisolone 30 or 50 mg/day for 7 days. During prednisolone administration antipyrine clearance decreased from 54.9 +/- 14.8 to 51.7 +/- 14.6 ml/min (mean +/- SD; p less than 0.05). The results indicate that prednisolone decreases the rate of antipyrine elimination, but not to an extent suggesting a clinically important change in hepatic drug metabolism.

AB - The influence of prednisolone on the elimination of antipyrine has been investigated. The one-sample antipyrine clearance was estimated in 23 outpatients with obstructive lung disease before and after treatment with prednisolone 30 or 50 mg/day for 7 days. During prednisolone administration antipyrine clearance decreased from 54.9 +/- 14.8 to 51.7 +/- 14.6 ml/min (mean +/- SD; p less than 0.05). The results indicate that prednisolone decreases the rate of antipyrine elimination, but not to an extent suggesting a clinically important change in hepatic drug metabolism.

KW - Antipyrine/pharmacokinetics

KW - Female

KW - Humans

KW - Liver/drug effects

KW - Lung Diseases, Obstructive/metabolism

KW - Male

KW - Metabolic Clearance Rate

KW - Middle Aged

KW - Prednisolone/pharmacology

U2 - 10.1007/BF00610387

DO - 10.1007/BF00610387

M3 - Journal article

C2 - 3691602

SN - 0031-6970

VL - 33

SP - 89

EP - 91

JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

IS - 1

ER -

Influence of prednisolone on antipyrine elimination in patients with obstructive lung disease

Abstract

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