Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Inflammatory Markers in Cerebrospinal Fluid from Patients with Hydrocephalus: A Systematic Literature Review

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

  1. Biomarkers for Alzheimer's Disease in Saliva: A Systematic Review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Physical activity enhances metabolic fitness independently of cardiorespiratory fitness in marathon runners

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Associations between oxidative stress and perceived stress in patients with bipolar disorder and healthy control individuals

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Endoskopisk behandling af hydrocefalus

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. B-waves are present in patients without intracranial pressure disturbances

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Lumbar puncture position influences intracranial pressure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Objective: The aim of this systematic review was to evaluate existing literature on inflammatory markers in CSF from patients with hydrocephalus and identify potential markers capable of promoting hydrocephalus development and progression.

Methods: Relevant studies published before December 3rd 2020 were identified from PubMed, Embase, and reference lists. Studies were screened for eligibility using the predefined inclusion and exclusion criteria. Data from eligible studies were extracted, and sources of bias were evaluated. We included articles written in English investigating inflammatory markers in CSF from patients with hydrocephalus and control subjects. The review was conducted according to the PRISMA guidelines by three independent reviewers.

Results: Twenty-two studies analyzed CSF from 311 patients with idiopathic normal pressure hydrocephalus (iNPH), 178 with posthemorrhagic hydrocephalus (PHH), 151 with other hydrocephalus diagnoses, and 394 control subjects. Fifty-eight inflammatory markers were investigated. The CSF of iNPH patients had increased CSF levels of IL-6, IL-1β, and LRG compared with control subjects, whereas the CSF of PHH patients had increased levels of IL-6, IL-18, and VEGF. CSF from patients with "other hydrocephalus diagnoses" had elevated IFN-γ compared to control subjects, and VEGF was increased in congenital hydrocephalus, spina bifida, and hydrocephalus associated with tuberculous meningitis compared with controls.

Conclusion: IL-6, IL-1β, LRG, IL-18, VEGF, and IFN-γ are elevated in CSF from patients with hydrocephalus and may be involved in promotion of hydrocephalus development and progression. They may serve as novel disease biomarkers, and their signaling pathways may represent targets for pharmacological management of hydrocephalus.

OriginalsprogEngelsk
Artikelnummer8834822
TidsskriftDisease Markers
Vol/bind2021
Sider (fra-til)8834822
ISSN0278-0240
DOI
StatusUdgivet - 2021

ID: 64685769