Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Inflammatory functional iron deficiency common in myelofibrosis, contributes to anaemia and impairs quality of life. From the Nordic MPN study Group

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Unexpected, isolated activated partial thromboplastin time prolongation: A practical mini-review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Heterozygous loss of Srp72 in mice is not associated with major hematological phenotypes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Addressing the room for improvement in management of acute promyelocytic leukemia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Risk factors for infections in newly diagnosed Multiple Myeloma patients: A Danish retrospective nationwide cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Prognostic role of genetic polymorphisms of the interleukin-6 signaling pathway in patients with severe heart failure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Associations between serum and plasma brain-derived neurotrophic factor and influence of storage time and centrifugation strategy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Pattern recognition receptor polymorphisms in early periodontitis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Statin treatment, oxidative stress and inflammation in a Danish population

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Gunnar Birgegard
  • Jan Samuelsson
  • Erik Ahlstrand
  • Elisabeth Ejerblad
  • Christian Enevold
  • Waleed Ghanima
  • Hans Hasselbalch
  • Claus H Nielsen
  • Håvar Knutsen
  • Ole B Pedersen
  • Anders Sørensen
  • Björn Andreasson
Vis graf over relationer

OBJECTIVES: The study investigates the hypothesis that inflammation in myelofibrosis (MF) like in myeloma and lymphoma, may disturb iron distribution and contribute to anaemia.

METHODS: A cross-sectional study of 80 MF and 23 ET patients was performed.

RESULTS: About 35% of anaemic MF patients had functional iron deficiency (FID) with transferrin saturation <20 and normal or elevated S-ferritin (<500 µg/L). In ET, FID was rare. In MF patients with FID, 70.6% were anaemic, vs 29.4% in patients without FID (P = 0.03). Hepcidin was significantly higher in MF patients with anaemia, including transfusion-dependent patients, 50.6 vs 24.4 µg/L (P = 0.01). There was a significant negative correlation between Hb and inflammatory markers in all MF patients: IL-2, IL-6 and TNF-α, (P < 0.01-0.03), LD (P = 0.004) and hepcidin (P = 0.03). These correlations were also seen in the subgroup of anaemic MF patients (Table ). Tsat correlated negatively with CRP (P < 0.001). Symptom burden was heavier in MF patients with FID, and MPN-SAF quality of life scores correlated with IL-6 and CRP.

CONCLUSIONS: The inflammatory state of MF disturbs iron turnover, FID is common and contributes to anaemia development and impairment of QoL. Anaemic MF patients should be screened for FID.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Haematology
Vol/bind102
Udgave nummer3
Sider (fra-til)235-240
Antal sider6
ISSN0902-4441
DOI
StatusUdgivet - mar. 2019

Bibliografisk note

© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

ID: 58906115