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Inflammation in Traumatic Brain Injury

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

Postolache, TT, Wadhawan, A, Can, A, Lowry, CA, Woodbury, M, Makkar, H, Hoisington, AJ, Scott, AJ, Potocki, E, Benros, ME & Stiller, JW 2020, 'Inflammation in Traumatic Brain Injury' Journal of Alzheimer's Disease, bind 74, nr. 1, s. 1-28. https://doi.org/10.3233/JAD-191150

APA

Postolache, T. T., Wadhawan, A., Can, A., Lowry, C. A., Woodbury, M., Makkar, H., ... Stiller, J. W. (2020). Inflammation in Traumatic Brain Injury. Journal of Alzheimer's Disease, 74(1), 1-28. https://doi.org/10.3233/JAD-191150

CBE

Postolache TT, Wadhawan A, Can A, Lowry CA, Woodbury M, Makkar H, Hoisington AJ, Scott AJ, Potocki E, Benros ME, Stiller JW. 2020. Inflammation in Traumatic Brain Injury. Journal of Alzheimer's Disease. 74(1):1-28. https://doi.org/10.3233/JAD-191150

MLA

Vancouver

Postolache TT, Wadhawan A, Can A, Lowry CA, Woodbury M, Makkar H o.a. Inflammation in Traumatic Brain Injury. Journal of Alzheimer's Disease. 2020;74(1):1-28. https://doi.org/10.3233/JAD-191150

Author

Postolache, Teodor T ; Wadhawan, Abhishek ; Can, Adem ; Lowry, Christopher A ; Woodbury, Margaret ; Makkar, Hina ; Hoisington, Andrew J ; Scott, Alison J ; Potocki, Eileen ; Benros, Michael E ; Stiller, John W. / Inflammation in Traumatic Brain Injury. I: Journal of Alzheimer's Disease. 2020 ; Bind 74, Nr. 1. s. 1-28.

Bibtex

@article{d24601683f024159953f0e08b5fa6588,
title = "Inflammation in Traumatic Brain Injury",
abstract = "There is an increasing evidence that inflammation contributes to clinical and functional outcomes in traumatic brain injury (TBI). Many successful target-engaging, lesion-reducing, symptom-alleviating, and function-improving interventions in animal models of TBI have failed to show efficacy in clinical trials. Timing and immunological context are paramount for the direction, quality, and intensity of immune responses to TBI and the resulting neuroanatomical, clinical, and functional course. We present components of the immune system implicated in TBI, potential immune targets, and target-engaging interventions. The main objective of our article is to point toward modifiable molecular and cellular mechanisms that may modify the outcomes in TBI, and contribute to increasing the translational value of interventions that have been identified in animal models of TBI.",
author = "Postolache, {Teodor T} and Abhishek Wadhawan and Adem Can and Lowry, {Christopher A} and Margaret Woodbury and Hina Makkar and Hoisington, {Andrew J} and Scott, {Alison J} and Eileen Potocki and Benros, {Michael E} and Stiller, {John W}",
year = "2020",
doi = "10.3233/JAD-191150",
language = "English",
volume = "74",
pages = "1--28",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
publisher = "I O S Press",
number = "1",

}

RIS

TY - JOUR

T1 - Inflammation in Traumatic Brain Injury

AU - Postolache, Teodor T

AU - Wadhawan, Abhishek

AU - Can, Adem

AU - Lowry, Christopher A

AU - Woodbury, Margaret

AU - Makkar, Hina

AU - Hoisington, Andrew J

AU - Scott, Alison J

AU - Potocki, Eileen

AU - Benros, Michael E

AU - Stiller, John W

PY - 2020

Y1 - 2020

N2 - There is an increasing evidence that inflammation contributes to clinical and functional outcomes in traumatic brain injury (TBI). Many successful target-engaging, lesion-reducing, symptom-alleviating, and function-improving interventions in animal models of TBI have failed to show efficacy in clinical trials. Timing and immunological context are paramount for the direction, quality, and intensity of immune responses to TBI and the resulting neuroanatomical, clinical, and functional course. We present components of the immune system implicated in TBI, potential immune targets, and target-engaging interventions. The main objective of our article is to point toward modifiable molecular and cellular mechanisms that may modify the outcomes in TBI, and contribute to increasing the translational value of interventions that have been identified in animal models of TBI.

AB - There is an increasing evidence that inflammation contributes to clinical and functional outcomes in traumatic brain injury (TBI). Many successful target-engaging, lesion-reducing, symptom-alleviating, and function-improving interventions in animal models of TBI have failed to show efficacy in clinical trials. Timing and immunological context are paramount for the direction, quality, and intensity of immune responses to TBI and the resulting neuroanatomical, clinical, and functional course. We present components of the immune system implicated in TBI, potential immune targets, and target-engaging interventions. The main objective of our article is to point toward modifiable molecular and cellular mechanisms that may modify the outcomes in TBI, and contribute to increasing the translational value of interventions that have been identified in animal models of TBI.

U2 - 10.3233/JAD-191150

DO - 10.3233/JAD-191150

M3 - Journal article

VL - 74

SP - 1

EP - 28

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

IS - 1

ER -

ID: 59581962