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Inflammation in Traumatic Brain Injury

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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  • Teodor T Postolache
  • Abhishek Wadhawan
  • Adem Can
  • Christopher A Lowry
  • Margaret Woodbury
  • Hina Makkar
  • Andrew J Hoisington
  • Alison J Scott
  • Eileen Potocki
  • Michael E Benros
  • John W Stiller
Vis graf over relationer

There is an increasing evidence that inflammation contributes to clinical and functional outcomes in traumatic brain injury (TBI). Many successful target-engaging, lesion-reducing, symptom-alleviating, and function-improving interventions in animal models of TBI have failed to show efficacy in clinical trials. Timing and immunological context are paramount for the direction, quality, and intensity of immune responses to TBI and the resulting neuroanatomical, clinical, and functional course. We present components of the immune system implicated in TBI, potential immune targets, and target-engaging interventions. The main objective of our article is to point toward modifiable molecular and cellular mechanisms that may modify the outcomes in TBI, and contribute to increasing the translational value of interventions that have been identified in animal models of TBI.

OriginalsprogEngelsk
TidsskriftJournal of Alzheimer's Disease
Vol/bind74
Udgave nummer1
Sider (fra-til)1-28
Antal sider28
ISSN1387-2877
DOI
StatusUdgivet - 2020

ID: 59581962