Inflammation, coagulation and cardiovascular disease in HIV-infected individuals

Daniel A Duprez; Jacqueline Neuhaus; Lewis H Kuller; Russell Tracy; Waldo Belloso; Stephane De Wit; Fraser Drummond; H Clifford Lane; Bruno Ledergerber; Jens Lundgren; Daniel Nixon; Nicholas I Paton; Ronald J Prineas; James D Neaton; INSIGHT SMART Study Group

doi:10.1371/journal.pone.0044454

Inflammation, coagulation and cardiovascular disease in HIV-infected individuals

Daniel A Duprez, Jacqueline Neuhaus, Lewis H Kuller, Russell Tracy, Waldo Belloso, Stephane De Wit, Fraser Drummond, H Clifford Lane, Bruno Ledergerber, Jens Lundgren, Daniel Nixon, Nicholas I Paton, Ronald J Prineas, James D Neaton, INSIGHT SMART Study Group

404 Citationer (Scopus)

Abstrakt

The SMART study was a trial of intermittent use of antiretroviral therapy (ART) (drug conservation [DC]) versus continuous use of ART (viral suppression [VS]) as a strategy to reduce toxicities, including cardiovascular disease (CVD) risk. We studied the predictive value of high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6) and D-dimer with CVD morbidity and mortality in HIV-infected patients who were enrolled in SMART beyond other measured CVD risk factors.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	7
Udgave nummer	9
Sider (fra-til)	e44454
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0044454
Status	Udgivet - 2012

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10.1371/journal.pone.0044454

Citationsformater

Duprez, D. A., Neuhaus, J., Kuller, L. H., Tracy, R., Belloso, W., De Wit, S., Drummond, F., Lane, H. C., Ledergerber, B., Lundgren, J., Nixon, D., Paton, N. I., Prineas, R. J., Neaton, J. D., & INSIGHT SMART Study Group (2012). Inflammation, coagulation and cardiovascular disease in HIV-infected individuals. P L o S One, 7(9), e44454. https://doi.org/10.1371/journal.pone.0044454

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abstract = "The SMART study was a trial of intermittent use of antiretroviral therapy (ART) (drug conservation [DC]) versus continuous use of ART (viral suppression [VS]) as a strategy to reduce toxicities, including cardiovascular disease (CVD) risk. We studied the predictive value of high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6) and D-dimer with CVD morbidity and mortality in HIV-infected patients who were enrolled in SMART beyond other measured CVD risk factors.",

author = "Duprez, {Daniel A} and Jacqueline Neuhaus and Kuller, {Lewis H} and Russell Tracy and Waldo Belloso and {De Wit}, Stephane and Fraser Drummond and Lane, {H Clifford} and Bruno Ledergerber and Jens Lundgren and Daniel Nixon and Paton, {Nicholas I} and Prineas, {Ronald J} and Neaton, {James D} and {INSIGHT SMART Study Group}",

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T1 - Inflammation, coagulation and cardiovascular disease in HIV-infected individuals

AU - Duprez, Daniel A

AU - Neuhaus, Jacqueline

AU - Kuller, Lewis H

AU - Tracy, Russell

AU - Belloso, Waldo

AU - De Wit, Stephane

AU - Drummond, Fraser

AU - Lane, H Clifford

AU - Ledergerber, Bruno

AU - Lundgren, Jens

AU - Nixon, Daniel

AU - Paton, Nicholas I

AU - Prineas, Ronald J

AU - Neaton, James D

AU - INSIGHT SMART Study Group

PY - 2012

Y1 - 2012

N2 - The SMART study was a trial of intermittent use of antiretroviral therapy (ART) (drug conservation [DC]) versus continuous use of ART (viral suppression [VS]) as a strategy to reduce toxicities, including cardiovascular disease (CVD) risk. We studied the predictive value of high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6) and D-dimer with CVD morbidity and mortality in HIV-infected patients who were enrolled in SMART beyond other measured CVD risk factors.

AB - The SMART study was a trial of intermittent use of antiretroviral therapy (ART) (drug conservation [DC]) versus continuous use of ART (viral suppression [VS]) as a strategy to reduce toxicities, including cardiovascular disease (CVD) risk. We studied the predictive value of high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6) and D-dimer with CVD morbidity and mortality in HIV-infected patients who were enrolled in SMART beyond other measured CVD risk factors.

U2 - 10.1371/journal.pone.0044454

DO - 10.1371/journal.pone.0044454

M3 - Journal article

C2 - 22970224

VL - 7

SP - e44454

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 9

ER -

Inflammation, coagulation and cardiovascular disease in HIV-infected individuals

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