Inflammation Associates With Impaired Small Arterial Elasticity Early in HIV Disease

INSIGHT START (Strategic Timing of AntiRetroviral Treatment) Study Group

doi:10.1093/ofid/ofy117

Inflammation Associates With Impaired Small Arterial Elasticity Early in HIV Disease

INSIGHT START (Strategic Timing of AntiRetroviral Treatment) Study Group

7 Citationer (Scopus)

Abstract

We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy-naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease.

Originalsprog	Engelsk
Tidsskrift	Open Forum Infectious Diseases
Vol/bind	5
Udgave nummer	6
Sider (fra-til)	ofy117
ISSN	2328-8957
DOI	https://doi.org/10.1093/ofid/ofy117
Status	Udgivet - 1 jun. 2018
Udgivet eksternt	Ja

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10.1093/ofid/ofy117

Citationsformater

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title = "Inflammation Associates With Impaired Small Arterial Elasticity Early in HIV Disease",

abstract = "We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy-na{\"i}ve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease.",

author = "Peterson, {Tess E} and {Huppler Hullsiek}, Katherine and {Wyman Engen}, Nicole and Nagalingeswaran Kumarasamy and Anne-Mette Lebech and Angelike Liappis and Antonios Papadopoulos and Polizzotto, {Mark N} and Schreiner, {Pamela J} and Daniel Duprez and Baker, {Jason V} and {INSIGHT START (Strategic Timing of AntiRetroviral Treatment) Study Group}",

year = "2018",

month = jun,

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doi = "10.1093/ofid/ofy117",

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TY - JOUR

T1 - Inflammation Associates With Impaired Small Arterial Elasticity Early in HIV Disease

AU - Peterson, Tess E

AU - Huppler Hullsiek, Katherine

AU - Wyman Engen, Nicole

AU - Kumarasamy, Nagalingeswaran

AU - Lebech, Anne-Mette

AU - Liappis, Angelike

AU - Papadopoulos, Antonios

AU - Polizzotto, Mark N

AU - Schreiner, Pamela J

AU - Duprez, Daniel

AU - Baker, Jason V

AU - INSIGHT START (Strategic Timing of AntiRetroviral Treatment) Study Group

PY - 2018/6/1

Y1 - 2018/6/1

N2 - We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy-naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease.

AB - We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy-naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease.

U2 - 10.1093/ofid/ofy117

DO - 10.1093/ofid/ofy117

M3 - Journal article

C2 - 29942822

SN - 2328-8957

VL - 5

SP - ofy117

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 6

ER -

Inflammation Associates With Impaired Small Arterial Elasticity Early in HIV Disease

Abstract

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