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Inflammation and Hypervascularization in a Large Animal Model of Knee Osteoarthritis: Imaging with Pathohistologic Correlation

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Harvard

Korchi, AM, Cengarle-Samak, A, Okuno, Y, Martel-Pelletier, J, Pelletier, JP, Boesen, M, Doyon, J, Bodson-Clermont, P, Lussier, B, Héon, H, Sapoval, M, Bureau, NJ & Soulez, G 2019, 'Inflammation and Hypervascularization in a Large Animal Model of Knee Osteoarthritis: Imaging with Pathohistologic Correlation', Journal of vascular and interventional radiology : JVIR, bind 30, nr. 7, s. 1116-1127. https://doi.org/10.1016/j.jvir.2018.09.031

APA

Korchi, A. M., Cengarle-Samak, A., Okuno, Y., Martel-Pelletier, J., Pelletier, J. P., Boesen, M., Doyon, J., Bodson-Clermont, P., Lussier, B., Héon, H., Sapoval, M., Bureau, N. J., & Soulez, G. (2019). Inflammation and Hypervascularization in a Large Animal Model of Knee Osteoarthritis: Imaging with Pathohistologic Correlation. Journal of vascular and interventional radiology : JVIR, 30(7), 1116-1127. https://doi.org/10.1016/j.jvir.2018.09.031

CBE

Korchi AM, Cengarle-Samak A, Okuno Y, Martel-Pelletier J, Pelletier JP, Boesen M, Doyon J, Bodson-Clermont P, Lussier B, Héon H, Sapoval M, Bureau NJ, Soulez G. 2019. Inflammation and Hypervascularization in a Large Animal Model of Knee Osteoarthritis: Imaging with Pathohistologic Correlation. Journal of vascular and interventional radiology : JVIR. 30(7):1116-1127. https://doi.org/10.1016/j.jvir.2018.09.031

MLA

Vancouver

Author

Korchi, Amine M ; Cengarle-Samak, Alexandre ; Okuno, Yuji ; Martel-Pelletier, Johanne ; Pelletier, Jean Pierre ; Boesen, Mikael ; Doyon, Josée ; Bodson-Clermont, Paule ; Lussier, Bertrand ; Héon, Hélène ; Sapoval, Marc ; Bureau, Nathalie J ; Soulez, Gilles. / Inflammation and Hypervascularization in a Large Animal Model of Knee Osteoarthritis : Imaging with Pathohistologic Correlation. I: Journal of vascular and interventional radiology : JVIR. 2019 ; Bind 30, Nr. 7. s. 1116-1127.

Bibtex

@article{181e9eb994a04a17924f2ef3b4663c7f,
title = "Inflammation and Hypervascularization in a Large Animal Model of Knee Osteoarthritis: Imaging with Pathohistologic Correlation",
abstract = "Purpose: To evaluate if synovial inflammation and hypervascularization are present in a dog model of knee osteoarthritis and can be detected on conventional magnetic resonance imaging (MRI), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), contrast-enhanced magnetic resonance imaging (CE-MRI), and quantitative digital subtraction angiography (Q-DSA) imaging. Materials and Methods: Six dogs underwent MRI and angiography of both knees before and 12 weeks after right knee anterior cruciate ligament injury. Synovial vascularity was evaluated on CE-MRI, DCE-MRI, and Q-DSA by 2 independent observers. Synovial inflammation and vascularity were histologically scored independently. Cartilage lesions and osteophytes were analyzed macroscopically, and cartilage volumetry was analyzed by MRI. Vascularity and osteoarthritis markers on imaging were compared before and after osteoarthritis generation, and between the osteoarthritis model and the control knee, using linear mixed models accounting for within-dog correlation. Results: In all knees, baseline imaging showed no abnormalities. Control knees did not develop significant osteoarthritis changes, synovial inflammation, or hypervascularization. In osteoarthritis knees, mean synovial enhancement score on CE-MR imaging increased by 13.1 ± 0.59 (P < .0001); mean synovial inflammation variable increased from 47.33 ± 18.61 to 407.97 ± 18.61 on DCE-MR imaging (P < .0001); and area under the curve on Q-DSA increased by 1058.58 ± 199.08 (P = .0043). Synovial inflammation, hypervascularization, and osteophyte formations were present in all osteoarthritis knees. Histology scores showed strong correlation with CE-MR imaging findings (Spearman correlation coefficient [SCC] = 0.742; P = .0002) and Q-DSA findings (SCC = 0.763; P < .0001) and weak correlation with DCE-MR imaging (SCC = -0.345; P = .329). Moderate correlation was found between CE-MR imaging and DSA findings (SCC = 0.536; P = .0004). Conclusions: In this early-stage knee osteoarthritis dog model, synovial inflammation and hypervascularization were found on imaging and confirmed by histology.",
author = "Korchi, {Amine M} and Alexandre Cengarle-Samak and Yuji Okuno and Johanne Martel-Pelletier and Pelletier, {Jean Pierre} and Mikael Boesen and Jos{\'e}e Doyon and Paule Bodson-Clermont and Bertrand Lussier and H{\'e}l{\`e}ne H{\'e}on and Marc Sapoval and Bureau, {Nathalie J} and Gilles Soulez",
note = "Copyright {\textcopyright} 2018 SIR. Published by Elsevier Inc. All rights reserved.",
year = "2019",
month = jul,
doi = "10.1016/j.jvir.2018.09.031",
language = "English",
volume = "30",
pages = "1116--1127",
journal = "Journal of Vascular and Interventional Radiology",
issn = "1051-0443",
publisher = "Elsevier Inc",
number = "7",

}

RIS

TY - JOUR

T1 - Inflammation and Hypervascularization in a Large Animal Model of Knee Osteoarthritis

T2 - Imaging with Pathohistologic Correlation

AU - Korchi, Amine M

AU - Cengarle-Samak, Alexandre

AU - Okuno, Yuji

AU - Martel-Pelletier, Johanne

AU - Pelletier, Jean Pierre

AU - Boesen, Mikael

AU - Doyon, Josée

AU - Bodson-Clermont, Paule

AU - Lussier, Bertrand

AU - Héon, Hélène

AU - Sapoval, Marc

AU - Bureau, Nathalie J

AU - Soulez, Gilles

N1 - Copyright © 2018 SIR. Published by Elsevier Inc. All rights reserved.

PY - 2019/7

Y1 - 2019/7

N2 - Purpose: To evaluate if synovial inflammation and hypervascularization are present in a dog model of knee osteoarthritis and can be detected on conventional magnetic resonance imaging (MRI), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), contrast-enhanced magnetic resonance imaging (CE-MRI), and quantitative digital subtraction angiography (Q-DSA) imaging. Materials and Methods: Six dogs underwent MRI and angiography of both knees before and 12 weeks after right knee anterior cruciate ligament injury. Synovial vascularity was evaluated on CE-MRI, DCE-MRI, and Q-DSA by 2 independent observers. Synovial inflammation and vascularity were histologically scored independently. Cartilage lesions and osteophytes were analyzed macroscopically, and cartilage volumetry was analyzed by MRI. Vascularity and osteoarthritis markers on imaging were compared before and after osteoarthritis generation, and between the osteoarthritis model and the control knee, using linear mixed models accounting for within-dog correlation. Results: In all knees, baseline imaging showed no abnormalities. Control knees did not develop significant osteoarthritis changes, synovial inflammation, or hypervascularization. In osteoarthritis knees, mean synovial enhancement score on CE-MR imaging increased by 13.1 ± 0.59 (P < .0001); mean synovial inflammation variable increased from 47.33 ± 18.61 to 407.97 ± 18.61 on DCE-MR imaging (P < .0001); and area under the curve on Q-DSA increased by 1058.58 ± 199.08 (P = .0043). Synovial inflammation, hypervascularization, and osteophyte formations were present in all osteoarthritis knees. Histology scores showed strong correlation with CE-MR imaging findings (Spearman correlation coefficient [SCC] = 0.742; P = .0002) and Q-DSA findings (SCC = 0.763; P < .0001) and weak correlation with DCE-MR imaging (SCC = -0.345; P = .329). Moderate correlation was found between CE-MR imaging and DSA findings (SCC = 0.536; P = .0004). Conclusions: In this early-stage knee osteoarthritis dog model, synovial inflammation and hypervascularization were found on imaging and confirmed by histology.

AB - Purpose: To evaluate if synovial inflammation and hypervascularization are present in a dog model of knee osteoarthritis and can be detected on conventional magnetic resonance imaging (MRI), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), contrast-enhanced magnetic resonance imaging (CE-MRI), and quantitative digital subtraction angiography (Q-DSA) imaging. Materials and Methods: Six dogs underwent MRI and angiography of both knees before and 12 weeks after right knee anterior cruciate ligament injury. Synovial vascularity was evaluated on CE-MRI, DCE-MRI, and Q-DSA by 2 independent observers. Synovial inflammation and vascularity were histologically scored independently. Cartilage lesions and osteophytes were analyzed macroscopically, and cartilage volumetry was analyzed by MRI. Vascularity and osteoarthritis markers on imaging were compared before and after osteoarthritis generation, and between the osteoarthritis model and the control knee, using linear mixed models accounting for within-dog correlation. Results: In all knees, baseline imaging showed no abnormalities. Control knees did not develop significant osteoarthritis changes, synovial inflammation, or hypervascularization. In osteoarthritis knees, mean synovial enhancement score on CE-MR imaging increased by 13.1 ± 0.59 (P < .0001); mean synovial inflammation variable increased from 47.33 ± 18.61 to 407.97 ± 18.61 on DCE-MR imaging (P < .0001); and area under the curve on Q-DSA increased by 1058.58 ± 199.08 (P = .0043). Synovial inflammation, hypervascularization, and osteophyte formations were present in all osteoarthritis knees. Histology scores showed strong correlation with CE-MR imaging findings (Spearman correlation coefficient [SCC] = 0.742; P = .0002) and Q-DSA findings (SCC = 0.763; P < .0001) and weak correlation with DCE-MR imaging (SCC = -0.345; P = .329). Moderate correlation was found between CE-MR imaging and DSA findings (SCC = 0.536; P = .0004). Conclusions: In this early-stage knee osteoarthritis dog model, synovial inflammation and hypervascularization were found on imaging and confirmed by histology.

UR - http://www.scopus.com/inward/record.url?scp=85063464456&partnerID=8YFLogxK

U2 - 10.1016/j.jvir.2018.09.031

DO - 10.1016/j.jvir.2018.09.031

M3 - Journal article

C2 - 30935868

VL - 30

SP - 1116

EP - 1127

JO - Journal of Vascular and Interventional Radiology

JF - Journal of Vascular and Interventional Radiology

SN - 1051-0443

IS - 7

ER -

ID: 58098540