Infective Endocarditis Following Transcatheter Aortic Valve Replacement: Comparison of Balloon- Versus Self-Expandable Valves

Ander Regueiro; Axel Linke; Azeem Latib; Nikolaj Ihlemann; Marina Urena; Thomas Walther; Oliver Husser; Howard Herrmann; Luis Nombela-Franco; Asim Cheema; Hervé Le Breton; Stefan Stortecky; Samir Kapadia; Antonio Bartorelli; Jan Malte Sinning; Ignacio Amat-Santos; Antonio Munoz-Garcia; Stamatios Lerakis; Enrique Gutíerrez-Ibanes; Mohamed Abdel-Wahab; Didier Tchetche; Luca Testa; Helene Eltchaninoff; Ugolino Livi; Juan Carlos Castillo; Hasan Jilaihawi; John Webb; Marco Barbanti; Susheel Kodali; Fabio de Brito Jr; Henrique Ribeiro; Antonio Miceli; Claudia Fiorina; Guglielmo Mario Actis Dato; Francesco Rosato; Vicenç Serra; Jean-Bernard Masson; Harindra Wijeysundera; Jose Mangione; Maria-Cristina Ferreira; Valter Lima; Luis Carvalho; Alexandre Abizaid; Marcos Marino; Vinicius Esteves; Julio Andrea; David Messika-Zeitoun; Dominique Himbert; Won-Keun Kim; Costanza Pellegrini; Vincent Auffret; Fabian Nietlispach; Thomas Pilgrim; Eric Durand; John Lisko; Raj Makkar; Pedro Lemos; Martin Leon; Rishi Puri; Alberto San Roman; Alec Vahanian; Lars Søndergaard; Norman Mangner; Josep Rodés-Cabau

doi:10.1161/CIRCINTERVENTIONS.119.007938

Infective Endocarditis Following Transcatheter Aortic Valve Replacement: Comparison of Balloon- Versus Self-Expandable Valves

Ander Regueiro, Axel Linke, Azeem Latib, Nikolaj Ihlemann, Marina Urena, Thomas Walther, Oliver Husser, Howard Herrmann, Luis Nombela-Franco, Asim Cheema, Hervé Le Breton, Stefan Stortecky, Samir Kapadia, Antonio Bartorelli, Jan Malte Sinning, Ignacio Amat-Santos, Antonio Munoz-Garcia, Stamatios Lerakis, Enrique Gutíerrez-Ibanes, Mohamed Abdel-WahabDidier Tchetche, Luca Testa, Helene Eltchaninoff, Ugolino Livi, Juan Carlos Castillo, Hasan Jilaihawi, John Webb, Marco Barbanti, Susheel Kodali, Fabio de Brito Jr, Henrique Ribeiro, Antonio Miceli, Claudia Fiorina, Guglielmo Mario Actis Dato, Francesco Rosato, Vicenç Serra, Jean-Bernard Masson, Harindra Wijeysundera, Jose Mangione, Maria-Cristina Ferreira, Valter Lima, Luis Carvalho, Alexandre Abizaid, Marcos Marino, Vinicius Esteves, Julio Andrea, David Messika-Zeitoun, Dominique Himbert, Won-Keun Kim, Costanza Pellegrini, Vincent Auffret, Fabian Nietlispach, Thomas Pilgrim, Eric Durand, John Lisko, Raj Makkar, Pedro Lemos, Martin Leon, Rishi Puri, Alberto San Roman, Alec Vahanian, Lars Søndergaard, Norman Mangner, Josep Rodés-Cabau

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42 Citationer (Scopus)

Abstract

BACKGROUND: No data exist about the characteristics of infective endocarditis (IE) post-transcatheter aortic valve replacement (TAVR) according to transcatheter valve type. We aimed to determine the incidence, clinical characteristics, and outcomes of patients with IE post-TAVR treated with balloon-expandable valve (BEV) versus self-expanding valve (SEV) systems.

METHODS: Data from the multicenter Infectious Endocarditis After TAVR International Registry was used to compare IE patients with BEV versus SEV.

RESULTS: A total of 245 patients with IE post-TAVR were included (SEV, 47%; BEV, 53%). The timing between TAVR and IE was similar between groups (SEV, 5.5 [1.2-15] months versus BEV, 5.3 [1.7-11.4] months; P=0.89). Enterococcal IE was more frequent in the SEV group (36.5% versus 15.4%; P<0.01), and vegetation location differed according to valve type (stent frame, SEV, 18.6%; BEV, 6.9%; P=0.01; valve leaflet, SEV, 23.9%; BEV, 38.5%; P=0.01). BEV recipients had a higher rate of stroke/systemic embolism (20.0% versus 8.7%, adjusted OR: 2.46, 95% CI: 1.04-5.82, P=0.04). Surgical explant of the transcatheter valve (SEV, 8.7%; BEV, 13.8%; P=0.21), and in-hospital death at the time of IE episode (SEV, 35.6%; BEV, 37.7%; P=0.74) were similar between groups. After a mean follow-up of 13±12 months, 59.1% and 54.6% of the SEV and BEV recipients, respectively, had died (P=0.66).

CONCLUSIONS: The characteristics of IE post-TAVR, including microorganism type, vegetation location, and embolic complications but not early or late mortality, differed according to valve type. These results may help to guide the diagnosis and management of IE and inform future research studies in the field.

Originalsprog	Engelsk
Tidsskrift	Circulation. Cardiovascular interventions
Vol/bind	12
Udgave nummer	11
Sider (fra-til)	e007938
ISSN	1941-7640
DOI	https://doi.org/10.1161/CIRCINTERVENTIONS.119.007938
Status	Udgivet - 2019

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10.1161/CIRCINTERVENTIONS.119.007938

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Regueiro, A., Linke, A., Latib, A., Ihlemann, N., Urena, M., Walther, T., Husser, O., Herrmann, H., Nombela-Franco, L., Cheema, A., Le Breton, H., Stortecky, S., Kapadia, S., Bartorelli, A., Sinning, J. M., Amat-Santos, I., Munoz-Garcia, A., Lerakis, S., Gutíerrez-Ibanes, E., ... Rodés-Cabau, J. (2019). Infective Endocarditis Following Transcatheter Aortic Valve Replacement: Comparison of Balloon- Versus Self-Expandable Valves. Circulation. Cardiovascular interventions, 12(11), e007938. https://doi.org/10.1161/CIRCINTERVENTIONS.119.007938

Regueiro, A, Linke, A, Latib, A, Ihlemann, N, Urena, M, Walther, T, Husser, O, Herrmann, H, Nombela-Franco, L, Cheema, A, Le Breton, H, Stortecky, S, Kapadia, S, Bartorelli, A, Sinning, JM, Amat-Santos, I, Munoz-Garcia, A, Lerakis, S, Gutíerrez-Ibanes, E, Abdel-Wahab, M, Tchetche, D, Testa, L, Eltchaninoff, H, Livi, U, Castillo, JC, Jilaihawi, H, Webb, J, Barbanti, M, Kodali, S, de Brito Jr, F, Ribeiro, H, Miceli, A, Fiorina, C, Actis Dato, GM, Rosato, F, Serra, V, Masson, J-B, Wijeysundera, H, Mangione, J, Ferreira, M-C, Lima, V, Carvalho, L, Abizaid, A, Marino, M, Esteves, V, Andrea, J, Messika-Zeitoun, D, Himbert, D, Kim, W-K, Pellegrini, C, Auffret, V, Nietlispach, F, Pilgrim, T, Durand, E, Lisko, J, Makkar, R, Lemos, P, Leon, M, Puri, R, San Roman, A, Vahanian, A, Søndergaard, L, Mangner, N & Rodés-Cabau, J 2019, 'Infective Endocarditis Following Transcatheter Aortic Valve Replacement: Comparison of Balloon- Versus Self-Expandable Valves', Circulation. Cardiovascular interventions, bind 12, nr. 11, s. e007938. https://doi.org/10.1161/CIRCINTERVENTIONS.119.007938

@article{6aaccdb4bfe9436f811e929dce1b9e0c,

title = "Infective Endocarditis Following Transcatheter Aortic Valve Replacement: Comparison of Balloon- Versus Self-Expandable Valves",

abstract = "BACKGROUND: No data exist about the characteristics of infective endocarditis (IE) post-transcatheter aortic valve replacement (TAVR) according to transcatheter valve type. We aimed to determine the incidence, clinical characteristics, and outcomes of patients with IE post-TAVR treated with balloon-expandable valve (BEV) versus self-expanding valve (SEV) systems.METHODS: Data from the multicenter Infectious Endocarditis After TAVR International Registry was used to compare IE patients with BEV versus SEV.RESULTS: A total of 245 patients with IE post-TAVR were included (SEV, 47%; BEV, 53%). The timing between TAVR and IE was similar between groups (SEV, 5.5 [1.2-15] months versus BEV, 5.3 [1.7-11.4] months; P=0.89). Enterococcal IE was more frequent in the SEV group (36.5% versus 15.4%; P<0.01), and vegetation location differed according to valve type (stent frame, SEV, 18.6%; BEV, 6.9%; P=0.01; valve leaflet, SEV, 23.9%; BEV, 38.5%; P=0.01). BEV recipients had a higher rate of stroke/systemic embolism (20.0% versus 8.7%, adjusted OR: 2.46, 95% CI: 1.04-5.82, P=0.04). Surgical explant of the transcatheter valve (SEV, 8.7%; BEV, 13.8%; P=0.21), and in-hospital death at the time of IE episode (SEV, 35.6%; BEV, 37.7%; P=0.74) were similar between groups. After a mean follow-up of 13±12 months, 59.1% and 54.6% of the SEV and BEV recipients, respectively, had died (P=0.66).CONCLUSIONS: The characteristics of IE post-TAVR, including microorganism type, vegetation location, and embolic complications but not early or late mortality, differed according to valve type. These results may help to guide the diagnosis and management of IE and inform future research studies in the field.",

author = "Ander Regueiro and Axel Linke and Azeem Latib and Nikolaj Ihlemann and Marina Urena and Thomas Walther and Oliver Husser and Howard Herrmann and Luis Nombela-Franco and Asim Cheema and {Le Breton}, Herv{\'e} and Stefan Stortecky and Samir Kapadia and Antonio Bartorelli and Sinning, {Jan Malte} and Ignacio Amat-Santos and Antonio Munoz-Garcia and Stamatios Lerakis and Enrique Gut{\'i}errez-Ibanes and Mohamed Abdel-Wahab and Didier Tchetche and Luca Testa and Helene Eltchaninoff and Ugolino Livi and Castillo, {Juan Carlos} and Hasan Jilaihawi and John Webb and Marco Barbanti and Susheel Kodali and {de Brito Jr}, Fabio and Henrique Ribeiro and Antonio Miceli and Claudia Fiorina and {Actis Dato}, {Guglielmo Mario} and Francesco Rosato and Vicen{\c c} Serra and Jean-Bernard Masson and Harindra Wijeysundera and Jose Mangione and Maria-Cristina Ferreira and Valter Lima and Luis Carvalho and Alexandre Abizaid and Marcos Marino and Vinicius Esteves and Julio Andrea and David Messika-Zeitoun and Dominique Himbert and Won-Keun Kim and Costanza Pellegrini and Vincent Auffret and Fabian Nietlispach and Thomas Pilgrim and Eric Durand and John Lisko and Raj Makkar and Pedro Lemos and Martin Leon and Rishi Puri and {San Roman}, Alberto and Alec Vahanian and Lars S{\o}ndergaard and Norman Mangner and Josep Rod{\'e}s-Cabau",

year = "2019",

doi = "10.1161/CIRCINTERVENTIONS.119.007938",

language = "English",

volume = "12",

pages = "e007938",

journal = "Circulation. Cardiovascular interventions",

issn = "1941-7640",

publisher = "Lippincott Williams & Wilkins",

number = "11",

}

TY - JOUR

T1 - Infective Endocarditis Following Transcatheter Aortic Valve Replacement

T2 - Comparison of Balloon- Versus Self-Expandable Valves

AU - Regueiro, Ander

AU - Linke, Axel

AU - Latib, Azeem

AU - Ihlemann, Nikolaj

AU - Urena, Marina

AU - Walther, Thomas

AU - Husser, Oliver

AU - Herrmann, Howard

AU - Nombela-Franco, Luis

AU - Cheema, Asim

AU - Le Breton, Hervé

AU - Stortecky, Stefan

AU - Kapadia, Samir

AU - Bartorelli, Antonio

AU - Sinning, Jan Malte

AU - Amat-Santos, Ignacio

AU - Munoz-Garcia, Antonio

AU - Lerakis, Stamatios

AU - Gutíerrez-Ibanes, Enrique

AU - Abdel-Wahab, Mohamed

AU - Tchetche, Didier

AU - Testa, Luca

AU - Eltchaninoff, Helene

AU - Livi, Ugolino

AU - Castillo, Juan Carlos

AU - Jilaihawi, Hasan

AU - Webb, John

AU - Barbanti, Marco

AU - Kodali, Susheel

AU - de Brito Jr, Fabio

AU - Ribeiro, Henrique

AU - Miceli, Antonio

AU - Fiorina, Claudia

AU - Actis Dato, Guglielmo Mario

AU - Rosato, Francesco

AU - Serra, Vicenç

AU - Masson, Jean-Bernard

AU - Wijeysundera, Harindra

AU - Mangione, Jose

AU - Ferreira, Maria-Cristina

AU - Lima, Valter

AU - Carvalho, Luis

AU - Abizaid, Alexandre

AU - Marino, Marcos

AU - Esteves, Vinicius

AU - Andrea, Julio

AU - Messika-Zeitoun, David

AU - Himbert, Dominique

AU - Kim, Won-Keun

AU - Pellegrini, Costanza

AU - Auffret, Vincent

AU - Nietlispach, Fabian

AU - Pilgrim, Thomas

AU - Durand, Eric

AU - Lisko, John

AU - Makkar, Raj

AU - Lemos, Pedro

AU - Leon, Martin

AU - Puri, Rishi

AU - San Roman, Alberto

AU - Vahanian, Alec

AU - Søndergaard, Lars

AU - Mangner, Norman

AU - Rodés-Cabau, Josep

PY - 2019

Y1 - 2019

N2 - BACKGROUND: No data exist about the characteristics of infective endocarditis (IE) post-transcatheter aortic valve replacement (TAVR) according to transcatheter valve type. We aimed to determine the incidence, clinical characteristics, and outcomes of patients with IE post-TAVR treated with balloon-expandable valve (BEV) versus self-expanding valve (SEV) systems.METHODS: Data from the multicenter Infectious Endocarditis After TAVR International Registry was used to compare IE patients with BEV versus SEV.RESULTS: A total of 245 patients with IE post-TAVR were included (SEV, 47%; BEV, 53%). The timing between TAVR and IE was similar between groups (SEV, 5.5 [1.2-15] months versus BEV, 5.3 [1.7-11.4] months; P=0.89). Enterococcal IE was more frequent in the SEV group (36.5% versus 15.4%; P<0.01), and vegetation location differed according to valve type (stent frame, SEV, 18.6%; BEV, 6.9%; P=0.01; valve leaflet, SEV, 23.9%; BEV, 38.5%; P=0.01). BEV recipients had a higher rate of stroke/systemic embolism (20.0% versus 8.7%, adjusted OR: 2.46, 95% CI: 1.04-5.82, P=0.04). Surgical explant of the transcatheter valve (SEV, 8.7%; BEV, 13.8%; P=0.21), and in-hospital death at the time of IE episode (SEV, 35.6%; BEV, 37.7%; P=0.74) were similar between groups. After a mean follow-up of 13±12 months, 59.1% and 54.6% of the SEV and BEV recipients, respectively, had died (P=0.66).CONCLUSIONS: The characteristics of IE post-TAVR, including microorganism type, vegetation location, and embolic complications but not early or late mortality, differed according to valve type. These results may help to guide the diagnosis and management of IE and inform future research studies in the field.

AB - BACKGROUND: No data exist about the characteristics of infective endocarditis (IE) post-transcatheter aortic valve replacement (TAVR) according to transcatheter valve type. We aimed to determine the incidence, clinical characteristics, and outcomes of patients with IE post-TAVR treated with balloon-expandable valve (BEV) versus self-expanding valve (SEV) systems.METHODS: Data from the multicenter Infectious Endocarditis After TAVR International Registry was used to compare IE patients with BEV versus SEV.RESULTS: A total of 245 patients with IE post-TAVR were included (SEV, 47%; BEV, 53%). The timing between TAVR and IE was similar between groups (SEV, 5.5 [1.2-15] months versus BEV, 5.3 [1.7-11.4] months; P=0.89). Enterococcal IE was more frequent in the SEV group (36.5% versus 15.4%; P<0.01), and vegetation location differed according to valve type (stent frame, SEV, 18.6%; BEV, 6.9%; P=0.01; valve leaflet, SEV, 23.9%; BEV, 38.5%; P=0.01). BEV recipients had a higher rate of stroke/systemic embolism (20.0% versus 8.7%, adjusted OR: 2.46, 95% CI: 1.04-5.82, P=0.04). Surgical explant of the transcatheter valve (SEV, 8.7%; BEV, 13.8%; P=0.21), and in-hospital death at the time of IE episode (SEV, 35.6%; BEV, 37.7%; P=0.74) were similar between groups. After a mean follow-up of 13±12 months, 59.1% and 54.6% of the SEV and BEV recipients, respectively, had died (P=0.66).CONCLUSIONS: The characteristics of IE post-TAVR, including microorganism type, vegetation location, and embolic complications but not early or late mortality, differed according to valve type. These results may help to guide the diagnosis and management of IE and inform future research studies in the field.

U2 - 10.1161/CIRCINTERVENTIONS.119.007938

DO - 10.1161/CIRCINTERVENTIONS.119.007938

M3 - Journal article

C2 - 31694412

SN - 1941-7640

VL - 12

SP - e007938

JO - Circulation. Cardiovascular interventions

JF - Circulation. Cardiovascular interventions

IS - 11

ER -

Infective Endocarditis Following Transcatheter Aortic Valve Replacement: Comparison of Balloon- Versus Self-Expandable Valves

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