Induction of beta-lactamase production in Pseudomonas aeruginosa biofilm

B Giwercman; E T Jensen; N Høiby; A Kharazmi; J W Costerton

doi:10.1128/AAC.35.5.1008

Induction of beta-lactamase production in Pseudomonas aeruginosa biofilm

B Giwercman, E T Jensen, N Høiby, A Kharazmi, J W Costerton

Abstract

Imipenem induced high levels of beta-lactamase production in Pseudomonas aeruginosa biofilms. Piperacillin also induced beta-lactamase production in these biofilms but to a lesser degree. The combination of beta-lactamase production with other protective properties of the biofilm mode of growth could be a major reason for the persistence of this sessile bacterium in chronic infections.

Originalsprog	Engelsk
Tidsskrift	Antimicrobial Agents and Chemotherapy
Vol/bind	35
Udgave nummer	5
Sider (fra-til)	1008-10
Antal sider	3
ISSN	0066-4804
DOI	https://doi.org/10.1128/AAC.35.5.1008
Status	Udgivet - maj 1991
Udgivet eksternt	Ja

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10.1128/AAC.35.5.1008

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@article{17d94329b02646278ff66caced012a9e,

title = "Induction of beta-lactamase production in Pseudomonas aeruginosa biofilm",

abstract = "Imipenem induced high levels of beta-lactamase production in Pseudomonas aeruginosa biofilms. Piperacillin also induced beta-lactamase production in these biofilms but to a lesser degree. The combination of beta-lactamase production with other protective properties of the biofilm mode of growth could be a major reason for the persistence of this sessile bacterium in chronic infections.",

keywords = "Culture Media, Enzyme Induction/drug effects, Hydrogen-Ion Concentration, Imipenem/pharmacology, Microbial Sensitivity Tests, Piperacillin/pharmacology, Pseudomonas aeruginosa/enzymology, beta-Lactamases/biosynthesis",

author = "B Giwercman and Jensen, {E T} and N H{\o}iby and A Kharazmi and Costerton, {J W}",

year = "1991",

month = may,

doi = "10.1128/AAC.35.5.1008",

language = "English",

volume = "35",

pages = "1008--10",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "5",

}

TY - JOUR

T1 - Induction of beta-lactamase production in Pseudomonas aeruginosa biofilm

AU - Giwercman, B

AU - Jensen, E T

AU - Høiby, N

AU - Kharazmi, A

AU - Costerton, J W

PY - 1991/5

Y1 - 1991/5

N2 - Imipenem induced high levels of beta-lactamase production in Pseudomonas aeruginosa biofilms. Piperacillin also induced beta-lactamase production in these biofilms but to a lesser degree. The combination of beta-lactamase production with other protective properties of the biofilm mode of growth could be a major reason for the persistence of this sessile bacterium in chronic infections.

AB - Imipenem induced high levels of beta-lactamase production in Pseudomonas aeruginosa biofilms. Piperacillin also induced beta-lactamase production in these biofilms but to a lesser degree. The combination of beta-lactamase production with other protective properties of the biofilm mode of growth could be a major reason for the persistence of this sessile bacterium in chronic infections.

KW - Culture Media

KW - Enzyme Induction/drug effects

KW - Hydrogen-Ion Concentration

KW - Imipenem/pharmacology

KW - Microbial Sensitivity Tests

KW - Piperacillin/pharmacology

KW - Pseudomonas aeruginosa/enzymology

KW - beta-Lactamases/biosynthesis

U2 - 10.1128/AAC.35.5.1008

DO - 10.1128/AAC.35.5.1008

M3 - Journal article

C2 - 1906694

SN - 0066-4804

VL - 35

SP - 1008

EP - 1010

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 5

ER -

Induction of beta-lactamase production in Pseudomonas aeruginosa biofilm

Abstract

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