Induction of beta-lactamase production in Pseudomonas aeruginosa biofilm

B Giwercman, E T Jensen, N Høiby, A Kharazmi, J W Costerton

Abstract

Imipenem induced high levels of beta-lactamase production in Pseudomonas aeruginosa biofilms. Piperacillin also induced beta-lactamase production in these biofilms but to a lesser degree. The combination of beta-lactamase production with other protective properties of the biofilm mode of growth could be a major reason for the persistence of this sessile bacterium in chronic infections.

OriginalsprogEngelsk
TidsskriftAntimicrobial Agents and Chemotherapy
Vol/bind35
Udgave nummer5
Sider (fra-til)1008-10
Antal sider3
ISSN0066-4804
DOI
StatusUdgivet - maj 1991
Udgivet eksterntJa

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