Induction chemotherapy with capecitabine and oxaliplatin followed by chemoradiotherapy before total mesorectal excision in patients with locally advanced rectal cancer

J.V.  Schou; F O Larsen; L Rasch; D Linnemann; J Langhoff; E Høgdall; D L Nielsen; K Vistisen; A Fromm; B V Jensen

doi:10.1093/annonc/mds056

Induction chemotherapy with capecitabine and oxaliplatin followed by chemoradiotherapy before total mesorectal excision in patients with locally advanced rectal cancer

J.V. Schou, F O Larsen, L Rasch, D Linnemann, J Langhoff, E Høgdall, D L Nielsen, K Vistisen, A Fromm, B V Jensen

95 Citationer (Scopus)

Abstract

Preoperative chemoradiation in patients with locally advanced rectal cancer has no impact on overall survival (OS) and distant recurrences. The aim of the study was to evaluate local downstaging, toxicity and long-term outcome in patients with locally advanced rectal cancer after induction therapy with capecitabine and oxaliplatin (CAPEOX) followed by radiotherapy concomitant with capecitabine [chemoradiotherapy (CRT)] before total mesorectal excision (TME).

Originalsprog	Engelsk
Tidsskrift	Annals of Oncology
Vol/bind	23
Udgave nummer	10
Sider (fra-til)	2627-33
Antal sider	7
ISSN	0923-7534
DOI	https://doi.org/10.1093/annonc/mds056
Status	Udgivet - 2012

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10.1093/annonc/mds056

Citationsformater

Schou, J. V., Larsen, F. O., Rasch, L., Linnemann, D., Langhoff, J., Høgdall, E., Nielsen, D. L., Vistisen, K., Fromm, A., & Jensen, B. V. (2012). Induction chemotherapy with capecitabine and oxaliplatin followed by chemoradiotherapy before total mesorectal excision in patients with locally advanced rectal cancer. Annals of Oncology, 23(10), 2627-33. https://doi.org/10.1093/annonc/mds056

Schou, JV, Larsen, FO, Rasch, L, Linnemann, D, Langhoff, J , Høgdall, E, Nielsen, DL, Vistisen, K, Fromm, A & Jensen, BV 2012, 'Induction chemotherapy with capecitabine and oxaliplatin followed by chemoradiotherapy before total mesorectal excision in patients with locally advanced rectal cancer', Annals of Oncology, bind 23, nr. 10, s. 2627-33. https://doi.org/10.1093/annonc/mds056

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abstract = "Preoperative chemoradiation in patients with locally advanced rectal cancer has no impact on overall survival (OS) and distant recurrences. The aim of the study was to evaluate local downstaging, toxicity and long-term outcome in patients with locally advanced rectal cancer after induction therapy with capecitabine and oxaliplatin (CAPEOX) followed by radiotherapy concomitant with capecitabine [chemoradiotherapy (CRT)] before total mesorectal excision (TME).",

author = "J.V. Schou and Larsen, {F O} and L Rasch and D Linnemann and J Langhoff and E H{\o}gdall and Nielsen, {D L} and K Vistisen and A Fromm and Jensen, {B V}",

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AU - Schou, J.V.

AU - Larsen, F O

AU - Rasch, L

AU - Linnemann, D

AU - Langhoff, J

AU - Høgdall, E

AU - Nielsen, D L

AU - Vistisen, K

AU - Fromm, A

AU - Jensen, B V

PY - 2012

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N2 - Preoperative chemoradiation in patients with locally advanced rectal cancer has no impact on overall survival (OS) and distant recurrences. The aim of the study was to evaluate local downstaging, toxicity and long-term outcome in patients with locally advanced rectal cancer after induction therapy with capecitabine and oxaliplatin (CAPEOX) followed by radiotherapy concomitant with capecitabine [chemoradiotherapy (CRT)] before total mesorectal excision (TME).

AB - Preoperative chemoradiation in patients with locally advanced rectal cancer has no impact on overall survival (OS) and distant recurrences. The aim of the study was to evaluate local downstaging, toxicity and long-term outcome in patients with locally advanced rectal cancer after induction therapy with capecitabine and oxaliplatin (CAPEOX) followed by radiotherapy concomitant with capecitabine [chemoradiotherapy (CRT)] before total mesorectal excision (TME).

U2 - 10.1093/annonc/mds056

DO - 10.1093/annonc/mds056

M3 - Journal article

C2 - 22473488

SN - 0923-7534

VL - 23

SP - 2627

EP - 2633

JO - Annals of Oncology

JF - Annals of Oncology

IS - 10

ER -

Induction chemotherapy with capecitabine and oxaliplatin followed by chemoradiotherapy before total mesorectal excision in patients with locally advanced rectal cancer

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