TY - JOUR
T1 - Increased systemic oxidatively generated DNA and RNA damage in schizophrenia
AU - Jorgensen, Anders
AU - Broedbaek, Kasper
AU - Fink-Jensen, Anders
AU - Knorr, Ulla
AU - Greisen Soendergaard, Mia
AU - Henriksen, Trine
AU - Weimann, Allan
AU - Jepsen, Peter
AU - Lykkesfeldt, Jens
AU - Enghusen Poulsen, Henrik
AU - Balslev Jorgensen, Martin
N1 - Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
PY - 2013/10
Y1 - 2013/10
N2 - Schizophrenia is associated with a substantially increased somatic morbidity and mortality, which may partly be caused by accelerated cellular aging. Oxidative stress is an established mediator of aging and a suggested aetiological mechanism in both schizophrenia and age-related medical disorders such as cardiovascular disease, type 2 diabetes and dementia. We determined the urinary excretion of markers of systemic Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) oxidation, 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-7,8-dihydroguanosine, respectively, in 40 schizophrenia patients and 40 age- and sex-matched controls, using ultra-performance liquid chromatography with tandem mass spectrometry. Measures of psychopathology, perceived stress and cortisol secretion were collected. Patients were re-examined after four months. We found a 20% increase in the median excretion of both markers in schizophrenia patients vs. healthy controls (P=0.003 and
AB - Schizophrenia is associated with a substantially increased somatic morbidity and mortality, which may partly be caused by accelerated cellular aging. Oxidative stress is an established mediator of aging and a suggested aetiological mechanism in both schizophrenia and age-related medical disorders such as cardiovascular disease, type 2 diabetes and dementia. We determined the urinary excretion of markers of systemic Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) oxidation, 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-7,8-dihydroguanosine, respectively, in 40 schizophrenia patients and 40 age- and sex-matched controls, using ultra-performance liquid chromatography with tandem mass spectrometry. Measures of psychopathology, perceived stress and cortisol secretion were collected. Patients were re-examined after four months. We found a 20% increase in the median excretion of both markers in schizophrenia patients vs. healthy controls (P=0.003 and
U2 - 10.1016/j.psychres.2013.01.033
DO - 10.1016/j.psychres.2013.01.033
M3 - Journal article
C2 - 23465294
SN - 1939-5949
VL - 209
SP - 417
EP - 423
JO - Psychiatry Research Journal
JF - Psychiatry Research Journal
IS - 3
ER -