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Increased short- and long-term mortality following infections in dementia: a nationwide registry-based cohort study

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@article{204bf782d94c4a0db934df792f2ba9bf,
title = "Increased short- and long-term mortality following infections in dementia: a nationwide registry-based cohort study",
abstract = "BACKGROUND AND PURPOSE: Mortality following infections in dementia has not yet been comprehensively explored. The aim of this cohort study was to investigate the short- and long-term mortality following infections in dementia.METHODS: Follow-up was from 1 January 2000 or the 65-year birthday until death, immigration, or 31 December 2015. Exposure was incident dementia and a first infection. The outcome was all-cause mortality. Mortality rate ratios (MRRs) were calculated using Poisson regression in 4 exposure groups (dementia yes/no, infection yes/no) by sex, infection site, and time since infection.RESULTS: 1,496,436 people were followed with 12,739,135 person-years. MRR in dementia/infection was 6.52 (95% confidence interval: 6.43-6.60) and was increased for infections of all sites. Increased mortality was short term (30 days) and long term (10 years).CONCLUSIONS: Increased mortality in people with dementia identifies them as a particularly vulnerable group that needs clinical attention.",
keywords = "dementia, epidemiology, infection, mortality, registry-based study, based study, registry&#8208",
author = "J Janbek and L Taudorf and Musaeus, {C S} and N Frimodt-M{\o}ller and Laursen, {T M} and G Waldemar",
note = "{\textcopyright} 2020 European Academy of Neurology.",
year = "2021",
month = feb,
doi = "10.1111/ene.14595",
language = "English",
volume = "28",
pages = "411--420",
journal = "European Journal of Neurology",
issn = "1351-5101",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Increased short- and long-term mortality following infections in dementia

T2 - a nationwide registry-based cohort study

AU - Janbek, J

AU - Taudorf, L

AU - Musaeus, C S

AU - Frimodt-Møller, N

AU - Laursen, T M

AU - Waldemar, G

N1 - © 2020 European Academy of Neurology.

PY - 2021/2

Y1 - 2021/2

N2 - BACKGROUND AND PURPOSE: Mortality following infections in dementia has not yet been comprehensively explored. The aim of this cohort study was to investigate the short- and long-term mortality following infections in dementia.METHODS: Follow-up was from 1 January 2000 or the 65-year birthday until death, immigration, or 31 December 2015. Exposure was incident dementia and a first infection. The outcome was all-cause mortality. Mortality rate ratios (MRRs) were calculated using Poisson regression in 4 exposure groups (dementia yes/no, infection yes/no) by sex, infection site, and time since infection.RESULTS: 1,496,436 people were followed with 12,739,135 person-years. MRR in dementia/infection was 6.52 (95% confidence interval: 6.43-6.60) and was increased for infections of all sites. Increased mortality was short term (30 days) and long term (10 years).CONCLUSIONS: Increased mortality in people with dementia identifies them as a particularly vulnerable group that needs clinical attention.

AB - BACKGROUND AND PURPOSE: Mortality following infections in dementia has not yet been comprehensively explored. The aim of this cohort study was to investigate the short- and long-term mortality following infections in dementia.METHODS: Follow-up was from 1 January 2000 or the 65-year birthday until death, immigration, or 31 December 2015. Exposure was incident dementia and a first infection. The outcome was all-cause mortality. Mortality rate ratios (MRRs) were calculated using Poisson regression in 4 exposure groups (dementia yes/no, infection yes/no) by sex, infection site, and time since infection.RESULTS: 1,496,436 people were followed with 12,739,135 person-years. MRR in dementia/infection was 6.52 (95% confidence interval: 6.43-6.60) and was increased for infections of all sites. Increased mortality was short term (30 days) and long term (10 years).CONCLUSIONS: Increased mortality in people with dementia identifies them as a particularly vulnerable group that needs clinical attention.

KW - dementia

KW - epidemiology

KW - infection

KW - mortality

KW - registry-based study

KW - based study

KW - registry&#8208

UR - http://www.scopus.com/inward/record.url?scp=85096708310&partnerID=8YFLogxK

U2 - 10.1111/ene.14595

DO - 10.1111/ene.14595

M3 - Journal article

C2 - 33065766

VL - 28

SP - 411

EP - 420

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

IS - 2

M1 - 2

ER -

ID: 61553386