Increased serum YKL-40 in patients with pulmonary sarcoidosis--a potential marker of disease activity?

Julia S Johansen, Nils Milman, Michael Hansen, Charly Garbarsch, Paul A Price, Niels Graudal

    87 Citationer (Scopus)

    Abstract

    YKL-40, a growth factor for fibroblasts and vascular endothelial cells, is secreted by macrophages and neutrophils. Elevated serum YKL-40 is found in patients with diseases characterized by inflammation, tissue remodelling and ongoing fibrosis. The aim was to evaluate whether macrophages and giant cells in the granulomatous sarcoid lesions of patients with pulmonary sarcoidosis produce YKL-40 and to determine whether serum YKL-40 in these patients were associated with disease activity.
    OriginalsprogEngelsk
    TidsskriftRespiratory medicine
    Vol/bind99
    Udgave nummer4
    Sider (fra-til)396-402
    Antal sider7
    ISSN0954-6111
    DOI
    StatusUdgivet - 1 apr. 2005

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