Increased serum levels of interleukin-18 in patients with multiple sclerosis

F Nicoletti, R Di Marco, K Mangano, F Patti, E Reggio, A Nicoletti, K Bendtzen, A Reggio

    77 Citationer (Scopus)

    Abstrakt

    Serum but not CSF concentrations of the interferon-gamma-inducing cytokine interleukin (IL)-18 were significantly augmented in patients with MS as compared to both healthy controls and patients with other neurologic diseases. Patients with MS with secondary chronic progressive disease had significantly higher serum levels than those with relapsing remitting MS. In the latter group, IL-18 levels were higher in patients with acute exacerbation as compared to those with stable disease.
    OriginalsprogEngelsk
    TidsskriftNeurology
    Vol/bind57
    Udgave nummer2
    Sider (fra-til)342-4
    Antal sider3
    ISSN0028-3878
    StatusUdgivet - 24 jul. 2001

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