Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Increased oxidation of RNA despite reduced mitochondrial respiration after chronic electroconvulsive stimulation of rat brain tissue

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. DNA methylation regulates CHRNA7 transcription and can be modulated by valproate

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Acetazolamide lowers intracranial pressure and modulates the cerebrospinal fluid secretion pathway in healthy rats

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. An oral NaV1.8 blocker improves motor function in mice completely deficient of myelin protein P0

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Serotonergic projections from the raphe nuclei to the subthalamic nucleus; a retrograde- and anterograde neuronal tracing study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Associations between oxidative stress and perceived stress in patients with bipolar disorder and healthy control individuals

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Hot and cold cognitive disturbances in antidepressant-free patients with major depressive disorder: a NeuroPharm study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. NeuroPharm study: EEG wakefulness regulation as a biomarker in MDD

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Major depressive disorder (MDD) affects 350 million people worldwide and is a serious socio-economic burden. The most efficient treatment of MDD is electroconvulsive therapy (ECT), which has been shown to influence the oxidative status believed to be part of the pathophysiology of MDD. We investigated the effects of chronic electroconvulsive stimulation (ECS) on mitochondrial respiration and mitochondrial hydrogen peroxide production, RNA oxidation, and the content of mitochondria in the piriform cortex of the rat. We found reductions of mitochondrial respiration in respiratory states 2 and 3 by 33% and 32%, respectively, and a 23% reduction in electron transfer capacity. RNA oxidation, as measured by 8-oxo-7,8-dihydroguanosine, was increased by 58%, while mitochondrial production of H2O2 was unaffected. The increased oxidative stress may thus be ascribed to extra-mitochondrial sources.

OriginalsprogEngelsk
TidsskriftNeuroscience Letters
Vol/bind690
Sider (fra-til)1-5
ISSN0304-3940
DOI
StatusUdgivet - 2019

ID: 55413998