Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Increased leptin, decreased adiponectin and FGF21 concentrations in adolescent offspring of women with gestational diabetes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Antidiabetic medication and risk of dementia in patients with type 2 diabetes. A nested case-control study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Duration of over- and under-treatment of hypothyroidism is associated with increased cardiovascular risk

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Effect of motivational interviewing on gestational weight gain and fetal growth in pregnant women with type 2 diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. White coat hypertension in early pregnancy in women with pre-existing diabetes: prevalence and pregnancy outcomes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Abdominal fat distribution measured by ultrasound and aerobic fitness in young Danish men born with low and normal birth weight

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Migration, body mass index and gestational diabetes mellitus among women in Denmark 2004-2015: a register-based study

    Publikation: KonferencebidragKonferenceabstrakt til konferenceForskningpeer review

Vis graf over relationer

Objective: Fetal exposure to gestational diabetes mellitus (GDM) increase s the risk of metabolic diseases in the offspring. Leptin, adiponectin, and fibroblast growth factor 21 ( FGF21) may play potential roles in the underlying disease mechanisms. We investigated the impact of fetal exposur e to GDM on leptin, adiponectin, and FGF21 concentrations and their associations with measures of adiposit y and metabolic traits during childhood/adolescence. Design and methods: The follow-up study included 504 GDM and 540 control offspring aged 9-16 from the Danish National Birth Cohort. Anthropometric measurements, fasting blood samples, puberty status and fat percentages by dual-energy X-ray absorptiometry were examined. Serum concen trations of leptin, adiponectin, and FGF21 were measured by validated immune assays. Results: GDM offspring had 38% (95% CI: 22-55%) higher leptin, 0.6 mg/L (95% CI: -1.2, -0.04 mg/L) lower adiponectin, and 32% (95% CI: -47%, -12%) lower FGF21 concentrations than control offspring (P < 0.05). After adjustment for confounders including maternal pre-pregnancy BMI, GDM offspring had borderline higher leptin (P = 0.06) and significantly lower FGF21 concentrations (P = 0.006). When accounting for offspring BMI z-score, GDM exposure had no significant independent effect on leptin or adiponectin concen trations, whereas FGF21 was still significant. In univariate analyses, leptin and adiponectin were associated wit h fasting insulin, HOMA-IR, and adiposity, and FGF21 with total fat percentage. Conclusions: GDM offspring had higher leptin, lower adiponectin and FGF21 co ncentrations than control offspring. Elevated leptin and decreased adiponectin concentrations associated with adverse metabolic traits and were most likely driven by higher obesity prevalence among GDM offspring. The functional implications of decreased FGF21 concentrations among GDM offspring need to be further explored.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Endocrinology
Vol/bind181
Udgave nummer6
Sider (fra-til)691-700
Antal sider10
ISSN0804-4643
DOI
StatusUdgivet - dec. 2019

ID: 58182733