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Udgivet

Increased immunopotency of monocyte derived dendritic cells from patients with optic neuritis is inhibited in vitro by simvastatin

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  1. Acute intermittent hypoxia boosts spinal plasticity in humans with tetraplegia

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  2. Axonal transport dysfunction of mitochondria in traumatic brain injury: A novel therapeutic target

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  3. Translating promising strategies for bowel and bladder management in spinal cord injury

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  4. Cutaneous noradrenaline measured by microdialysis in complex regional pain syndrome during whole-body cooling and heating

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  1. Manufacture of adoptive cell therapies at academic cancer centers: scientific, safety and regulatory challenges

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  2. Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
Multiple sclerosis (MS) is an autoimmune disease where myelin-reactive lymphocytes and their activation depend on interactions with antigen presenting cells (APCs). Dendritic cells (DC) are professional APCs dependent on maturation to attain full T-cell priming capacity. The immunomodulatory properties of simvastatin influence the function of both T cells and APCs and could thus be a potential therapy for MS. The phenotype of myeloid DC in untreated patients with monosymptomatic optic neuritis (ON) was determined by flow cytometry and the impact of simvastatin on the function of myeloid DC derived from peripheral blood mononuclear cells (PBMC) was analysed in vitro. DC from ON patients had more mature phenotype compared with healthy controls (HC). Particularly the fraction of DC expressing CD1a and CD80 was significantly higher in ON than in HC (P
OriginalsprogEngelsk
TidsskriftExperimental Neurology
Vol/bind221
Udgave nummer2
Sider (fra-til)320-8
Antal sider9
ISSN0014-4886
DOI
StatusUdgivet - 1 feb. 2010

ID: 32313274