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Increased expression and activity of group IIA and X secretory phospholipase A2 in peritumoral versus central colon carcinoma tissue

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  1. The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma

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  2. Annexin A2 and S100A10 as Candidate Prognostic Markers in Epithelial Ovarian Cancer

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  3. Association of CD31 and p53 With Survival of Ovarian Cancer Patients

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  4. The Influence of Cyst Emptying, Lymph Node Resection and Chemotherapy on Survival in Stage IA and IC1 Epithelial Ovarian Cancer

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  1. Triage May Improve Selection to Colonoscopy and Reduce the Number of Unnecessary Colonoscopies

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  2. Early Detection and Recurrence of Colorectal Adenomas by Combination of Eight Cancer-Associated Biomarkers in Plasma

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  3. Gel-Based Proteomics of Clinical Samples Identifies Potential Serological Biomarkers for Early Detection of Colorectal Cancer

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  • Line Tribler
  • Lotte T Jensen
  • Kent Jørgensen
  • Nils Brünner
  • Michael H Gelb
  • Hans Jørgen Nielsen
  • Simon S Jensen
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Secretory phospholipase A2 (sPLA2) type IIA and X was analyzed in tumors from 22 patients with colon adenocarcinomas in order to determine the involvement and activity of sPLA2 in colon cancer. Evaluation of immunoreactive sPLA2 IIA by Western blotting showed a significantly higher level in the periphery of the tumors, compared to central tumor regions. Increased levels of sPLA2 IIA protein correlated with a two-fold increase in sPLA2 enzymatic activity in the peripheral regions compared to central regions. Nineteen out of 22 tumors showed high levels of sPLA2 IIA, whereas 7 out of the 22 tumors showed sPLA2 type X. These data demonstrate that both sPLA2 type IIA and X are present in human colon cancer and suggest a role for sPLA2 in colon cancer tumor immunology and tumorigenesis.
OriginalsprogEngelsk
TidsskriftAnticancer Research
Vol/bind27
Udgave nummer5A
Sider (fra-til)3179-86
Antal sider7
ISSN0250-7005
StatusUdgivet - 2007

ID: 32535843