Increased beta rhythm as an indicator of inhibitory mechanisms in tourette syndrome

Valentina Niccolai; Hanneke van Dijk; Stephanie Franzkowiak; Jennifer Finis; Martin Südmeyer; Melanie Jonas; Götz Thomalla; Hartwig Roman Siebner; Kirsten Müller-Vahl; Alexander Münchau; Alfons Schnitzler; Katja Biermann-Ruben

doi:10.1002/mds.26454

Increased beta rhythm as an indicator of inhibitory mechanisms in tourette syndrome

Valentina Niccolai, Hanneke van Dijk, Stephanie Franzkowiak, Jennifer Finis, Martin Südmeyer, Melanie Jonas, Götz Thomalla, Hartwig Roman Siebner, Kirsten Müller-Vahl, Alexander Münchau, Alfons Schnitzler, Katja Biermann-Ruben

17 Citationer (Scopus)

Abstract

BACKGROUND: Inhibitory oscillatory mechanisms subserving tic compensation have been put forward in Tourette syndrome. Modulation of the beta rhythm (15-25 Hz) as the well-established oscillatory movement execution-inhibition indicator was tested during a cognitive-motor task in patients with Tourette syndrome.

METHODS: Performing a Go/NoGo task, 12 patients with Tourette syndrome and 12 matched controls were recorded using whole-head magnetoencephalography.

RESULTS: Compared to healthy participants, patients showed less beta suppression in the sensorimotor area and enhanced beta power in parieto-occipital brain regions contralaterally to the response hand. Average beta power and power gain correlated negatively with tic severity.

CONCLUSIONS: Increased motor inhibitory as well as visuomotor attentional processes are likely to subserve tic compensation. Correlational results suggest that stronger inhibitory compensation accompanies less tic severity. © 2015 International Parkinson and Movement Disorder Society.

Originalsprog	Engelsk
Tidsskrift	Movement disorders : official journal of the Movement Disorder Society
Vol/bind	31
Udgave nummer	3
Sider (fra-til)	384-392
Antal sider	9
ISSN	0885-3185
DOI	https://doi.org/10.1002/mds.26454
Status	Udgivet - 9 dec. 2015

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10.1002/mds.26454

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Niccolai, V., van Dijk, H., Franzkowiak, S., Finis, J., Südmeyer, M., Jonas, M., Thomalla, G., Siebner, H. R., Müller-Vahl, K., Münchau, A., Schnitzler, A., & Biermann-Ruben, K. (2015). Increased beta rhythm as an indicator of inhibitory mechanisms in tourette syndrome. Movement disorders : official journal of the Movement Disorder Society, 31(3), 384-392. https://doi.org/10.1002/mds.26454

Niccolai, V, van Dijk, H, Franzkowiak, S, Finis, J, Südmeyer, M, Jonas, M, Thomalla, G, Siebner, HR, Müller-Vahl, K, Münchau, A, Schnitzler, A & Biermann-Ruben, K 2015, 'Increased beta rhythm as an indicator of inhibitory mechanisms in tourette syndrome', Movement disorders : official journal of the Movement Disorder Society, bind 31, nr. 3, s. 384-392. https://doi.org/10.1002/mds.26454

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title = "Increased beta rhythm as an indicator of inhibitory mechanisms in tourette syndrome",

abstract = "BACKGROUND: Inhibitory oscillatory mechanisms subserving tic compensation have been put forward in Tourette syndrome. Modulation of the beta rhythm (15-25 Hz) as the well-established oscillatory movement execution-inhibition indicator was tested during a cognitive-motor task in patients with Tourette syndrome.METHODS: Performing a Go/NoGo task, 12 patients with Tourette syndrome and 12 matched controls were recorded using whole-head magnetoencephalography.RESULTS: Compared to healthy participants, patients showed less beta suppression in the sensorimotor area and enhanced beta power in parieto-occipital brain regions contralaterally to the response hand. Average beta power and power gain correlated negatively with tic severity.CONCLUSIONS: Increased motor inhibitory as well as visuomotor attentional processes are likely to subserve tic compensation. Correlational results suggest that stronger inhibitory compensation accompanies less tic severity. {\textcopyright} 2015 International Parkinson and Movement Disorder Society.",

author = "Valentina Niccolai and {van Dijk}, Hanneke and Stephanie Franzkowiak and Jennifer Finis and Martin S{\"u}dmeyer and Melanie Jonas and G{\"o}tz Thomalla and Siebner, {Hartwig Roman} and Kirsten M{\"u}ller-Vahl and Alexander M{\"u}nchau and Alfons Schnitzler and Katja Biermann-Ruben",

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year = "2015",

month = dec,

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doi = "10.1002/mds.26454",

language = "English",

volume = "31",

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AU - Niccolai, Valentina

AU - van Dijk, Hanneke

AU - Franzkowiak, Stephanie

AU - Finis, Jennifer

AU - Südmeyer, Martin

AU - Jonas, Melanie

AU - Thomalla, Götz

AU - Siebner, Hartwig Roman

AU - Müller-Vahl, Kirsten

AU - Münchau, Alexander

AU - Schnitzler, Alfons

AU - Biermann-Ruben, Katja

PY - 2015/12/9

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N2 - BACKGROUND: Inhibitory oscillatory mechanisms subserving tic compensation have been put forward in Tourette syndrome. Modulation of the beta rhythm (15-25 Hz) as the well-established oscillatory movement execution-inhibition indicator was tested during a cognitive-motor task in patients with Tourette syndrome.METHODS: Performing a Go/NoGo task, 12 patients with Tourette syndrome and 12 matched controls were recorded using whole-head magnetoencephalography.RESULTS: Compared to healthy participants, patients showed less beta suppression in the sensorimotor area and enhanced beta power in parieto-occipital brain regions contralaterally to the response hand. Average beta power and power gain correlated negatively with tic severity.CONCLUSIONS: Increased motor inhibitory as well as visuomotor attentional processes are likely to subserve tic compensation. Correlational results suggest that stronger inhibitory compensation accompanies less tic severity. © 2015 International Parkinson and Movement Disorder Society.

AB - BACKGROUND: Inhibitory oscillatory mechanisms subserving tic compensation have been put forward in Tourette syndrome. Modulation of the beta rhythm (15-25 Hz) as the well-established oscillatory movement execution-inhibition indicator was tested during a cognitive-motor task in patients with Tourette syndrome.METHODS: Performing a Go/NoGo task, 12 patients with Tourette syndrome and 12 matched controls were recorded using whole-head magnetoencephalography.RESULTS: Compared to healthy participants, patients showed less beta suppression in the sensorimotor area and enhanced beta power in parieto-occipital brain regions contralaterally to the response hand. Average beta power and power gain correlated negatively with tic severity.CONCLUSIONS: Increased motor inhibitory as well as visuomotor attentional processes are likely to subserve tic compensation. Correlational results suggest that stronger inhibitory compensation accompanies less tic severity. © 2015 International Parkinson and Movement Disorder Society.

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DO - 10.1002/mds.26454

M3 - Journal article

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JO - Movement disorders : official journal of the Movement Disorder Society

JF - Movement disorders : official journal of the Movement Disorder Society

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ER -

Increased beta rhythm as an indicator of inhibitory mechanisms in tourette syndrome

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