TY - JOUR
T1 - Incidence of Sudden Cardiac Death in the European Union
AU - Empana, Jean-Philippe
AU - Lerner, Ivan
AU - Valentin, Eugenie
AU - Folke, Fredrik
AU - Böttiger, Bernd
AU - Gislason, Gunnar
AU - Jonsson, Martin
AU - Ringh, Mattias
AU - Beganton, Frankie
AU - Bougouin, Wulfran
AU - Marijon, Eloi
AU - Blom, Marieke
AU - Tan, Hanno
AU - Jouven, Xavier
AU - ESCAPE-NET Investigators
N1 - Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
PY - 2022/5/10
Y1 - 2022/5/10
N2 - BACKGROUND: Although sudden cardiac death (SCD) is recognized as a high-priority public health topic, reliable estimates of the incidence of SCD or, more broadly, out-of-hospital cardiac arrest (OHCA), in the population are scarce, especially in the European Union.OBJECTIVES: The study objective was to determine the incidence of SCD and OHCA in the European Union.METHODS: The study examined 4 large (ie, >2 million inhabitants) European population-based prospective registries collecting emergency medical services (EMS)-attended (ie, with attempted resuscitation) OHCA and SCD (OHCA without obvious extracardiac causes) for >5 consecutive years from January 2012 to December 2017 in the Paris region (France), the North Holland region (the Netherlands), the Stockholm region (Sweden), and in all of Denmark.RESULTS: The average annual incidence of SCD in the 4 registries ranged from 36.8 per 100,000 (95% CI: 23.5-50.1 per 100,000) to 39.7 per 100,000 (95% CI: 32.6-46.8 per 100,000). When extrapolating to each European country and accounting for age and sex, this yields to 249,538 SCD cases per year (95% CI: 155,377-343,719 SCD cases per year). The average annual incidence of OHCA in the 4 registries ranged from 47.8 per 100,000 (95% CI: 21.2-74.4 per 100,000) to 57.9 per 100,000 (95% CI: 19.6-96.3 per 100,000), corresponding to 343,496 OHCA cases per year (95% CI: 216,472-464,922 OHCA cases per year) in the European Union. Incidence rates of SCD and OHCA increased with age and were systematically higher in men compared with women.CONCLUSIONS: By combining data from 4 large, population-based registries with at least 5 years of data collection, this study provided an estimate of the incidence of SCD and OHCA in the European Union.
AB - BACKGROUND: Although sudden cardiac death (SCD) is recognized as a high-priority public health topic, reliable estimates of the incidence of SCD or, more broadly, out-of-hospital cardiac arrest (OHCA), in the population are scarce, especially in the European Union.OBJECTIVES: The study objective was to determine the incidence of SCD and OHCA in the European Union.METHODS: The study examined 4 large (ie, >2 million inhabitants) European population-based prospective registries collecting emergency medical services (EMS)-attended (ie, with attempted resuscitation) OHCA and SCD (OHCA without obvious extracardiac causes) for >5 consecutive years from January 2012 to December 2017 in the Paris region (France), the North Holland region (the Netherlands), the Stockholm region (Sweden), and in all of Denmark.RESULTS: The average annual incidence of SCD in the 4 registries ranged from 36.8 per 100,000 (95% CI: 23.5-50.1 per 100,000) to 39.7 per 100,000 (95% CI: 32.6-46.8 per 100,000). When extrapolating to each European country and accounting for age and sex, this yields to 249,538 SCD cases per year (95% CI: 155,377-343,719 SCD cases per year). The average annual incidence of OHCA in the 4 registries ranged from 47.8 per 100,000 (95% CI: 21.2-74.4 per 100,000) to 57.9 per 100,000 (95% CI: 19.6-96.3 per 100,000), corresponding to 343,496 OHCA cases per year (95% CI: 216,472-464,922 OHCA cases per year) in the European Union. Incidence rates of SCD and OHCA increased with age and were systematically higher in men compared with women.CONCLUSIONS: By combining data from 4 large, population-based registries with at least 5 years of data collection, this study provided an estimate of the incidence of SCD and OHCA in the European Union.
KW - Cardiopulmonary Resuscitation
KW - Death, Sudden, Cardiac/epidemiology
KW - Emergency Medical Services
KW - European Union
KW - Female
KW - Humans
KW - Incidence
KW - Male
KW - Out-of-Hospital Cardiac Arrest/epidemiology
KW - Prospective Studies
KW - Registries
UR - http://www.scopus.com/inward/record.url?scp=85129416614&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2022.02.041
DO - 10.1016/j.jacc.2022.02.041
M3 - Journal article
C2 - 35512862
VL - 79
SP - 1818
EP - 1827
JO - American College of Cardiology. Journal
JF - American College of Cardiology. Journal
SN - 0735-1097
IS - 18
ER -