Incidence and impact of parvovirus B19 infection in seronegative solid organ transplant recipients

Omid Rezahosseini; Christina Ekenberg; Dina Leth Møller; Søren Schwartz Sørensen; Neval Ete Wareham; Michael Perch; Finn Gustafsson; Allan Rasmussen; Nikolai Kirkby; Joanne Reekie; Jens Lundgren; Susanne Dam Nielsen

doi:10.1093/infdis/jiab024

Incidence and impact of parvovirus B19 infection in seronegative solid organ transplant recipients

Omid Rezahosseini, Christina Ekenberg, Dina Leth Møller, Søren Schwartz Sørensen, Neval Ete Wareham, Michael Perch, Finn Gustafsson, Allan Rasmussen, Nikolai Kirkby, Joanne Reekie, Jens Lundgren, Susanne Dam Nielsen

Abstract

Routine monitoring of parvovirus B19 (B19V) the first 6 months posttransplantation was performed in 241 seronegative solid organ transplant (SOT) recipients. Incidence rates during the first month and the second to sixth months posttransplantation were 1.2 (95% confidence interval [CI], .33-3.2) and 0.21 (95% CI, .06-.57) per 100 recipients per month, respectively. Of the 6 SOT recipients with positive B19V polymerase chain reaction, 3 (50%) were admitted to hospital and 2 (33%) were treated with intravenous immunoglobulin. Thus, routine monitoring of B19V in seronegative SOT recipients may not be necessary. Targeted screening 1 month posttransplantation and screening upon clinical suspicion could be an alternative strategy.

Originalsprog	Engelsk
Tidsskrift	The Journal of infectious diseases
Vol/bind	224
Udgave nummer	5
Sider (fra-til)	865-869
Antal sider	5
ISSN	0022-1899
DOI	https://doi.org/10.1093/infdis/jiab024
Status	Udgivet - 1 sep. 2021

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10.1093/infdis/jiab024

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Rezahosseini, O., Ekenberg, C., Møller, D. L., Sørensen, S. S., Wareham, N. E., Perch, M., Gustafsson, F., Rasmussen, A., Kirkby, N., Reekie, J., Lundgren, J., & Nielsen, S. D. (2021). Incidence and impact of parvovirus B19 infection in seronegative solid organ transplant recipients. The Journal of infectious diseases, 224(5), 865-869. https://doi.org/10.1093/infdis/jiab024

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title = "Incidence and impact of parvovirus B19 infection in seronegative solid organ transplant recipients",

abstract = "Routine monitoring of parvovirus B19 (B19V) the first 6 months posttransplantation was performed in 241 seronegative solid organ transplant (SOT) recipients. Incidence rates during the first month and the second to sixth months posttransplantation were 1.2 (95% confidence interval [CI], .33-3.2) and 0.21 (95% CI, .06-.57) per 100 recipients per month, respectively. Of the 6 SOT recipients with positive B19V polymerase chain reaction, 3 (50%) were admitted to hospital and 2 (33%) were treated with intravenous immunoglobulin. Thus, routine monitoring of B19V in seronegative SOT recipients may not be necessary. Targeted screening 1 month posttransplantation and screening upon clinical suspicion could be an alternative strategy.",

author = "Omid Rezahosseini and Christina Ekenberg and M{\o}ller, {Dina Leth} and S{\o}rensen, {S{\o}ren Schwartz} and Wareham, {Neval Ete} and Michael Perch and Finn Gustafsson and Allan Rasmussen and Nikolai Kirkby and Joanne Reekie and Jens Lundgren and Nielsen, {Susanne Dam}",

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doi = "10.1093/infdis/jiab024",

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T1 - Incidence and impact of parvovirus B19 infection in seronegative solid organ transplant recipients

AU - Rezahosseini, Omid

AU - Ekenberg, Christina

AU - Møller, Dina Leth

AU - Sørensen, Søren Schwartz

AU - Wareham, Neval Ete

AU - Perch, Michael

AU - Gustafsson, Finn

AU - Rasmussen, Allan

AU - Kirkby, Nikolai

AU - Reekie, Joanne

AU - Lundgren, Jens

AU - Nielsen, Susanne Dam

PY - 2021/9/1

Y1 - 2021/9/1

N2 - Routine monitoring of parvovirus B19 (B19V) the first 6 months posttransplantation was performed in 241 seronegative solid organ transplant (SOT) recipients. Incidence rates during the first month and the second to sixth months posttransplantation were 1.2 (95% confidence interval [CI], .33-3.2) and 0.21 (95% CI, .06-.57) per 100 recipients per month, respectively. Of the 6 SOT recipients with positive B19V polymerase chain reaction, 3 (50%) were admitted to hospital and 2 (33%) were treated with intravenous immunoglobulin. Thus, routine monitoring of B19V in seronegative SOT recipients may not be necessary. Targeted screening 1 month posttransplantation and screening upon clinical suspicion could be an alternative strategy.

AB - Routine monitoring of parvovirus B19 (B19V) the first 6 months posttransplantation was performed in 241 seronegative solid organ transplant (SOT) recipients. Incidence rates during the first month and the second to sixth months posttransplantation were 1.2 (95% confidence interval [CI], .33-3.2) and 0.21 (95% CI, .06-.57) per 100 recipients per month, respectively. Of the 6 SOT recipients with positive B19V polymerase chain reaction, 3 (50%) were admitted to hospital and 2 (33%) were treated with intravenous immunoglobulin. Thus, routine monitoring of B19V in seronegative SOT recipients may not be necessary. Targeted screening 1 month posttransplantation and screening upon clinical suspicion could be an alternative strategy.

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U2 - 10.1093/infdis/jiab024

DO - 10.1093/infdis/jiab024

M3 - Journal article

C2 - 33458766

SN - 0022-1899

VL - 224

SP - 865

EP - 869

JO - The Journal of infectious diseases

JF - The Journal of infectious diseases

IS - 5

ER -

Incidence and impact of parvovirus B19 infection in seronegative solid organ transplant recipients

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