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In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Multi-site benchmarking of clinical 13C RF coils at 3T

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Dynamic nuclear polarization and optimal control spatial-selective (13)C MRI and MRS

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Planar quadrature coil design using shielded-loop resonators.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Multi-site benchmarking of clinical 13C RF coils at 3T

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. High Intrarenal Lactate Production Inhibits the Renal Pseudohypoxic Response to Acutely Induced Hypoxia in Diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Calibrated Coil Combination for Fixed-Geometry, Low-Frequency Coils with Application to Hyperpolarized 13C Measurements

    Publikation: KonferencebidragKonferenceabstrakt til konferenceForskningpeer review

  5. Data-driven Nyquist ghost correction for hyperpolarized 13C EPSI and EPI

    Publikation: KonferencebidragKonferenceabstrakt til konferenceForskningpeer review

  • Rita Schmidt
  • Christoffer Laustsen
  • Jean-Nicolas Dumez
  • Mikko I Kettunen
  • Eva M Serrao
  • Irene Marco-Rius
  • Kevin M Brindle
  • Jan Henrik Ardenkjaer-Larsen
  • Lucio Frydman
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Hyperpolarized metabolic imaging is a growing field that has provided a new tool for analyzing metabolism, particularly in cancer. Given the short life times of the hyperpolarized signal, fast and effective spectroscopic imaging methods compatible with dynamic metabolic characterizations are necessary. Several approaches have been customized for hyperpolarized (13)C MRI, including CSI with a center-out k-space encoding, EPSI, and spectrally selective pulses in combination with spiral EPI acquisitions. Recent studies have described the potential of single-shot alternatives based on spatiotemporal encoding (SPEN) principles, to derive chemical-shift images within a sub-second period. By contrast to EPSI, SPEN does not require oscillating acquisition gradients to deliver chemical-shift information: its signal encodes both spatial as well as chemical shift information, at no extra cost in experimental complexity. SPEN MRI sequences with slice-selection and arbitrary excitation pulses can also be devised, endowing SPEN with the potential to deliver single-shot multi-slice chemical shift images, with a temporal resolution required for hyperpolarized dynamic metabolic imaging. The present work demonstrates this with initial in vivo results obtained from SPEN-based imaging of pyruvate and its metabolic products, after injection of hyperpolarized [1-(13)C]pyruvate. Multi-slice chemical-shift images of healthy rats were obtained at 4.7T in the region of the kidney, and 4D (2D spatial, 1D spectral, 1D temporal) data sets were obtained at 7T from a murine lymphoma tumor model.

OriginalsprogEngelsk
TidsskriftJournal of magnetic resonance (San Diego, Calif. : 1997)
Vol/bind240
Sider (fra-til)8-15
Antal sider8
ISSN1090-7807
DOI
StatusUdgivet - mar. 2014

ID: 45048429