In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR120) in Aspergillus fumigatus cyp51A, Denmark

Rasmus K Hare, Jan B Gertsen, Karen M T Astvad, Kristine B Degn, Anders Løkke, Marc Stegger, Paal S Andersen, Lise Kristensen, Maiken C Arendrup

Abstract

We report a fatal aspergillosis case in which STRAf typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A. This event, previously restricted to the environment, challenges current understanding of azole resistance development in A. fumigatus.

OriginalsprogEngelsk
TidsskriftEmerging Infectious Diseases (Print Edition)
Vol/bind25
Udgave nummer3
Sider (fra-til)577-580
Antal sider4
ISSN1080-6040
DOI
StatusUdgivet - mar. 2019

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