@article{e14bb1dc99b84ee6886d2cbd1d7bab53,
title = "In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR120) in Aspergillus fumigatus cyp51A, Denmark",
abstract = "We report a fatal aspergillosis case in which STRAf typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A. This event, previously restricted to the environment, challenges current understanding of azole resistance development in A. fumigatus.",
keywords = "Aspergillosis/diagnosis, Aspergillus fumigatus/drug effects, Azoles/pharmacology, Cytochrome P-450 Enzyme System/genetics, Denmark/epidemiology, Drug Resistance, Fungal, Fungal Proteins/genetics, Humans, Male, Middle Aged, Mutation, Phylogeny, Promoter Regions, Genetic, Selection, Genetic, Tandem Repeat Sequences, Tomography, X-Ray Computed",
author = "Hare, {Rasmus K} and Gertsen, {Jan B} and Astvad, {Karen M T} and Degn, {Kristine B} and Anders L{\o}kke and Marc Stegger and Andersen, {Paal S} and Lise Kristensen and Arendrup, {Maiken C}",
year = "2019",
month = mar,
doi = "10.3201/eid2503.180297",
language = "English",
volume = "25",
pages = "577--580",
journal = "Emerging Infectious Diseases ",
issn = "1080-6040",
publisher = "U.S. Department of Health and Human Services Centers for Disease Control and Prevention",
number = "3",
}