Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

In vivo expression of neuroglobin in reactive astrocytes during neuropathology in murine models of traumatic brain injury, cerebral malaria, and autoimmune encephalitis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Spontaneous astrocytic Ca2+ activity abounds in electrically suppressed ischemic penumbra of aged mice

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Fast Ca2+ responses in astrocyte end-feet and neurovascular coupling in mice

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Antibiotic prescribing in paediatric inpatients in Ghana: a multi-centre point prevalence survey

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Population Pharmacokinetics of the Antimalarial Amodiaquine: a Pooled Analysis To Optimize Dosing

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Traffic flow and microbial air contamination in operating rooms at a major teaching hospital in Ghana

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Detection of Glycan Shedding in the Blood: New Class of Multiple Sclerosis Biomarkers?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
Neuroglobin (Ngb) is proposed to be a neuron-specific, hypoxia-responsive, neuroprotective protein. However, results are conflicting concerning both Ngb's physiological and pathological significance. This study was designed to investigate the in vivo localization and regulation of Ngb in different neuropathological models representing traumatic injury, infectious, autoimmune, and excitotoxic pathogeneses. We profiled Ngb immunohistochemistry in murine models of traumatic brain injury, cerebral malaria, experimental autoimmune encephalitis, and kainic acid (KA)-mediated epileptic seizures that, to our knowledge, have not been studied in the context of Ngb. In control mice Ngb was expressed exclusively in neurons. In all pathological models except KA, in addition to neurons Ngb was present in reactive astrocytes. Ngb positive astrocytes were found within regions associated with most severe pathology and the astroglial scar. This is the first report of Ngb present in reactive astroglia and in scar-forming astrocytes in response to different pathological conditions relevant to human disease. In light of previously reported cyto-protective properties of Ngb, further insight may result in therapeutic ramifications.
OriginalsprogEngelsk
TidsskriftGLIA
Vol/bind58
Udgave nummer10
Sider (fra-til)1220-7
Antal sider8
ISSN0894-1491
DOI
StatusUdgivet - 1 aug. 2010

ID: 32186229