@article{dc81214247834da8946611c94df9e9dd,
title = "In vivo emergence of Aspergillus terreus with reduced azole susceptibility and a Cyp51a M217I alteration",
abstract = "Azole resistance in Aspergillus terreus isolates was explored. Twenty related (MB) and 6 unrelated A. terreus isolates were included. CYP51A sequencing and RAPD genotyping was performed. Five MB isolates were itraconazole susceptible, whereas the minimum inhibitory concentrations (MICs) for 15 MB isolates were elevated (1-2 mg/L). Voriconazole and posaconazole MICs were 0.5-4 and 0.06-0.5 mg/L, respectively, for MB isolates but 0.25-0.5 and ",
keywords = "Antifungal Agents, Aspergillus, Azoles, Cytochrome P-450 Enzyme System, DNA, Fungal, Drug Resistance, Multiple, Fungal, Fungal Proteins, Gene Expression Regulation, Fungal, Genotype, Humans, Itraconazole, Microbial Sensitivity Tests, Mutation",
author = "Arendrup, {Maiken C} and Rasmus Jensen and Katharina Grif and Marianne Skov and Tanja Pressler and Johansen, {Helle K} and Cornelia Lass-Fl{\"o}rl",
year = "2012",
doi = "10.1093/infdis/jis442",
language = "English",
volume = "206",
pages = "981--5",
journal = "The Journal of infectious diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "6",
}