In vitro evaluation of avidin antibody pretargeting using 211At-labeled and biotinylated poly-L-lysine as effector molecule

Sofia H L Frost; Holger Lau Jensen; Sture Lindegren

doi:10.1002/cncr.24798

In vitro evaluation of avidin antibody pretargeting using 211At-labeled and biotinylated poly-L-lysine as effector molecule

Sofia H L Frost, Holger Lau Jensen, Sture Lindegren

Afdeling for Klinisk Fysiologi og Nuklearmedicin

17 Citationer (Scopus)

Abstract

Pretargeting is an approach for enhancing the therapeutic index of radioimmunotherapy by separating the administrations of tumor-targeting substance and radiolabel. In this study, a pretargeting model system of avidin-conjugated monoclonal antibody trastuzumab and biotinylated, (211)At-labeled poly-L-lysine was constructed and analyzed in vitro.

Originalsprog	Engelsk
Tidsskrift	Cancer
Vol/bind	116
Udgave nummer	4 Suppl
Sider (fra-til)	1101-10
Antal sider	10
ISSN	0008-543X
DOI	https://doi.org/10.1002/cncr.24798
Status	Udgivet - 15 feb. 2010

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10.1002/cncr.24798

Citationsformater

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title = "In vitro evaluation of avidin antibody pretargeting using 211At-labeled and biotinylated poly-L-lysine as effector molecule",

abstract = "Pretargeting is an approach for enhancing the therapeutic index of radioimmunotherapy by separating the administrations of tumor-targeting substance and radiolabel. In this study, a pretargeting model system of avidin-conjugated monoclonal antibody trastuzumab and biotinylated, (211)At-labeled poly-L-lysine was constructed and analyzed in vitro.",

author = "Frost, {Sofia H L} and Jensen, {Holger Lau} and Sture Lindegren",

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TY - JOUR

T1 - In vitro evaluation of avidin antibody pretargeting using 211At-labeled and biotinylated poly-L-lysine as effector molecule

AU - Frost, Sofia H L

AU - Jensen, Holger Lau

AU - Lindegren, Sture

PY - 2010/2/15

Y1 - 2010/2/15

N2 - Pretargeting is an approach for enhancing the therapeutic index of radioimmunotherapy by separating the administrations of tumor-targeting substance and radiolabel. In this study, a pretargeting model system of avidin-conjugated monoclonal antibody trastuzumab and biotinylated, (211)At-labeled poly-L-lysine was constructed and analyzed in vitro.

AB - Pretargeting is an approach for enhancing the therapeutic index of radioimmunotherapy by separating the administrations of tumor-targeting substance and radiolabel. In this study, a pretargeting model system of avidin-conjugated monoclonal antibody trastuzumab and biotinylated, (211)At-labeled poly-L-lysine was constructed and analyzed in vitro.

U2 - 10.1002/cncr.24798

DO - 10.1002/cncr.24798

M3 - Journal article

C2 - 20127953

SN - 0008-543X

VL - 116

SP - 1101

EP - 1110

JO - Cancer

JF - Cancer

IS - 4 Suppl

ER -

In vitro evaluation of avidin antibody pretargeting using 211At-labeled and biotinylated poly-L-lysine as effector molecule

Abstract

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