In vitro evaluation of avidin antibody pretargeting using 211At-labeled and biotinylated poly-L-lysine as effector molecule

Sofia H L Frost, Holger Lau Jensen, Sture Lindegren

16 Citationer (Scopus)

Abstract

Pretargeting is an approach for enhancing the therapeutic index of radioimmunotherapy by separating the administrations of tumor-targeting substance and radiolabel. In this study, a pretargeting model system of avidin-conjugated monoclonal antibody trastuzumab and biotinylated, (211)At-labeled poly-L-lysine was constructed and analyzed in vitro.
OriginalsprogEngelsk
TidsskriftCancer
Vol/bind116
Udgave nummer4 Suppl
Sider (fra-til)1101-10
Antal sider10
ISSN0008-543X
DOI
StatusUdgivet - 15 feb. 2010

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