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In Vitro and In Vivo Evaluation of Pellotine: A Hypnotic Lophophora Alkaloid
Christian B M Poulie
, Camilla B Chan
, Aleksandra Parka
, Magnus Lettorp
, Josephine Vos
, Amanda Raaschou
, Eline Pottie
, Mikkel S Bundgaard
, Louis M E Sørensen
, Claudia R Cecchi
, Emil Märcher-Rørsted
, Anders Bach
, Matthias M Herth
, Ann Decker
, Anders A Jensen
, Betina Elfving
, Andreas C Kretschmann
, Christophe P Stove
, Kristi A Kohlmeier
, Claus Cornett
Christian Janfelt, Birgitte R Kornum, Jesper L Kristensen
*
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*
Corresponding author af dette arbejde
Afdeling for Klinisk Fysiologi og Nuklearmedicin
6
Citationer (Scopus)
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Keyphrases
Serotonergic System
100%
Metabolism
100%
Mouse Liver
100%
In Vitro Evaluation
100%
Emax
100%
EC50
100%
Alkaloids
100%
5-HT6
100%
Liver Microsomes
100%
Lophophora
100%
Inverse Agonist
50%
Quality of Life
50%
Serotonin 5-HT
50%
Central Nervous System
50%
Rodents
50%
Benzodiazepines
50%
Active Metabolite
50%
Radioligand
50%
REM Sleep
50%
Short-acting
50%
Locomotion
50%
Hypnotic Effect
50%
Sleep Fragmentation
50%
Insomnia
50%
5-HT7 Receptor
50%
5-HT7
50%
Phase II Metabolism
50%
Human Liver Microsomes
50%
N-oxides
50%
Phase I Metabolites
50%
O-glucuronides
50%
Sleep-wake Disorders
50%
Displacement Assay
50%
Diastereomers
50%
In Vitro Properties
50%
Desorption Electrospray Ionization Mass Spectrometry Imaging (DESI-MSI)
50%
Neuroscience
In Vivo
100%
In Vitro
100%
Microsome
100%
Alkaloid
100%
Serotonin
66%
Metabolic Pathway
66%
Inverse Agonist
33%
Central Nervous System
33%
Agonist
33%
Sleep Disorder
33%
Radioligand
33%
Rapid Eye Movement Sleep
33%
5-HT Receptor
33%
Glucuronide
33%
5-HT7 Receptor
33%
Quality of Life
33%
Side Effect
33%
Serotonergic System
33%
Oxide
33%
Pharmacology, Toxicology and Pharmaceutical Science
Serotonin
100%
EC50
100%
Alkaloid
100%
Receptor
50%
Active Metabolite
50%
Sleep Disorder
50%
Radioligand
50%
Serotonin Receptor
50%
Inverse Agonist
50%
Glucuronide
50%
Ulifloxacin
50%
Side Effect
50%
Oxide
50%
Biochemistry, Genetics and Molecular Biology
Metabolite
100%
Alkaloid
100%
Metabolic Pathway
66%
EC50
66%
Serotonin
66%
Agonist
33%
Inverse Agonist
33%
Radioligand
33%
REM Sleep
33%
Serotonergic
33%
Glucuronide
33%
5-HT Receptor
33%
5-HT7 Receptor
33%
Diastereoisomer
33%