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Improving preparedness to respond to cross-border hepatitis A outbreaks in the European Union/European Economic Area: towards comparable sequencing of hepatitis A virus

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Enkirch, T, Severi, E, Vennema, H, Thornton, L, Dean, J, Borg, M-L, Ciccaglione, AR, Bruni, R, Christova, I, Ngui, SL, Balogun, K, Němeček, V, Kontio, M, Takács, M, Hettmann, A, Korotinska, R, Löve, A, Avellón, A, Muñoz-Chimeno, M, de Sousa, R, Janta, D, Epštein, J, Klamer, S, Suin, V, Aberle, SW, Holzmann, H, Mellou, K, Ederth, JL, Sundqvist, L, Roque-Afonso, A-M, Filipović, SK, Poljak, M, Vold, L, Stene-Johansen, K, Midgley, S, Fischer, TK, Faber, M, Wenzel, JJ, Takkinen, J & Leitmeyer, K 2019, 'Improving preparedness to respond to cross-border hepatitis A outbreaks in the European Union/European Economic Area: towards comparable sequencing of hepatitis A virus' Eurosurveillance, bind 24, nr. 28. https://doi.org/10.2807/1560-7917.ES.2019.24.28.1800397

APA

CBE

Enkirch T, Severi E, Vennema H, Thornton L, Dean J, Borg M-L, Ciccaglione AR, Bruni R, Christova I, Ngui SL, Balogun K, Němeček V, Kontio M, Takács M, Hettmann A, Korotinska R, Löve A, Avellón A, Muñoz-Chimeno M, de Sousa R, Janta D, Epštein J, Klamer S, Suin V, Aberle SW, Holzmann H, Mellou K, Ederth JL, Sundqvist L, Roque-Afonso A-M, Filipović SK, Poljak M, Vold L, Stene-Johansen K, Midgley S, Fischer TK, Faber M, Wenzel JJ, Takkinen J, Leitmeyer K. 2019. Improving preparedness to respond to cross-border hepatitis A outbreaks in the European Union/European Economic Area: towards comparable sequencing of hepatitis A virus. Eurosurveillance. 24(28). https://doi.org/10.2807/1560-7917.ES.2019.24.28.1800397

MLA

Vancouver

Author

Enkirch, Theresa ; Severi, Ettore ; Vennema, Harry ; Thornton, Lelia ; Dean, Jonathan ; Borg, Maria-Louise ; Ciccaglione, Anna Rita ; Bruni, Roberto ; Christova, Iva ; Ngui, Siew Lin ; Balogun, Koye ; Němeček, Vratislav ; Kontio, Mia ; Takács, Mária ; Hettmann, Andrea ; Korotinska, Rita ; Löve, Arthur ; Avellón, Ana ; Muñoz-Chimeno, Milagros ; de Sousa, Rita ; Janta, Denisa ; Epštein, Jevgenia ; Klamer, Sofieke ; Suin, Vanessa ; Aberle, Stephan W ; Holzmann, Heidemarie ; Mellou, Kassiani ; Ederth, Josefine Lundberg ; Sundqvist, Lena ; Roque-Afonso, Anne-Marie ; Filipović, Sanja Kurečić ; Poljak, Mario ; Vold, Line ; Stene-Johansen, Kathrine ; Midgley, Sofie ; Fischer, Thea Kølsen ; Faber, Mirko ; Wenzel, Jürgen J ; Takkinen, Johanna ; Leitmeyer, Katrin. / Improving preparedness to respond to cross-border hepatitis A outbreaks in the European Union/European Economic Area : towards comparable sequencing of hepatitis A virus. I: Eurosurveillance. 2019 ; Bind 24, Nr. 28.

Bibtex

@article{ce7fa474a010463ab389c5fe557321db,
title = "Improving preparedness to respond to cross-border hepatitis A outbreaks in the European Union/European Economic Area: towards comparable sequencing of hepatitis A virus",
abstract = "IntroductionSequence-based typing of hepatitis A virus (HAV) is important for outbreak detection, investigation and surveillance. In 2013, sequencing was central to resolving a large European Union (EU)-wide outbreak related to frozen berries. However, as the sequenced HAV genome regions were only partly comparable between countries, results were not always conclusive.AimThe objective was to gather information on HAV surveillance and sequencing in EU/European Economic Area (EEA) countries to find ways to harmonise their procedures, for improvement of cross-border outbreak responses.MethodsIn 2014, the European Centre for Disease Prevention and Control (ECDC) conducted a survey on HAV surveillance practices in EU/EEA countries. The survey enquired whether a referral system for confirming primary diagnostics of hepatitis A existed as well as a central collection/storage of hepatitis A cases' samples for typing. Questions on HAV sequencing procedures were also asked. Based on the results, an expert consultation proposed harmonised procedures for cross-border outbreak response, in particular regarding sequencing. In 2016, a follow-up survey assessed uptake of suggested methods.ResultsOf 31 EU/EEA countries, 23 (2014) and 27 (2016) participated. Numbers of countries with central collection and storage of HAV positive samples and of those performing sequencing increased from 12 to 15 and 12 to 14 respectively in 2016, with all countries typing an overlapping fragment of 218 nt. However, variation existed in the sequenced genomic regions and their lengths.ConclusionsWhile HAV sequences in EU/EEA countries are comparable for surveillance, collaboration in sharing and comparing these can be further strengthened.",
author = "Theresa Enkirch and Ettore Severi and Harry Vennema and Lelia Thornton and Jonathan Dean and Maria-Louise Borg and Ciccaglione, {Anna Rita} and Roberto Bruni and Iva Christova and Ngui, {Siew Lin} and Koye Balogun and Vratislav Němeček and Mia Kontio and M{\'a}ria Tak{\'a}cs and Andrea Hettmann and Rita Korotinska and Arthur L{\"o}ve and Ana Avell{\'o}n and Milagros Mu{\~n}oz-Chimeno and {de Sousa}, Rita and Denisa Janta and Jevgenia Epštein and Sofieke Klamer and Vanessa Suin and Aberle, {Stephan W} and Heidemarie Holzmann and Kassiani Mellou and Ederth, {Josefine Lundberg} and Lena Sundqvist and Anne-Marie Roque-Afonso and Filipović, {Sanja Kurečić} and Mario Poljak and Line Vold and Kathrine Stene-Johansen and Sofie Midgley and Fischer, {Thea K{\o}lsen} and Mirko Faber and Wenzel, {J{\"u}rgen J} and Johanna Takkinen and Katrin Leitmeyer",
year = "2019",
doi = "10.2807/1560-7917.ES.2019.24.28.1800397",
language = "English",
volume = "24",
journal = "Eurosurveillance",
issn = "1560-7917",
publisher = "Centre Europeen pour la Surveillance Epidemiologique du SIDA",
number = "28",

}

RIS

TY - JOUR

T1 - Improving preparedness to respond to cross-border hepatitis A outbreaks in the European Union/European Economic Area

T2 - towards comparable sequencing of hepatitis A virus

AU - Enkirch, Theresa

AU - Severi, Ettore

AU - Vennema, Harry

AU - Thornton, Lelia

AU - Dean, Jonathan

AU - Borg, Maria-Louise

AU - Ciccaglione, Anna Rita

AU - Bruni, Roberto

AU - Christova, Iva

AU - Ngui, Siew Lin

AU - Balogun, Koye

AU - Němeček, Vratislav

AU - Kontio, Mia

AU - Takács, Mária

AU - Hettmann, Andrea

AU - Korotinska, Rita

AU - Löve, Arthur

AU - Avellón, Ana

AU - Muñoz-Chimeno, Milagros

AU - de Sousa, Rita

AU - Janta, Denisa

AU - Epštein, Jevgenia

AU - Klamer, Sofieke

AU - Suin, Vanessa

AU - Aberle, Stephan W

AU - Holzmann, Heidemarie

AU - Mellou, Kassiani

AU - Ederth, Josefine Lundberg

AU - Sundqvist, Lena

AU - Roque-Afonso, Anne-Marie

AU - Filipović, Sanja Kurečić

AU - Poljak, Mario

AU - Vold, Line

AU - Stene-Johansen, Kathrine

AU - Midgley, Sofie

AU - Fischer, Thea Kølsen

AU - Faber, Mirko

AU - Wenzel, Jürgen J

AU - Takkinen, Johanna

AU - Leitmeyer, Katrin

PY - 2019

Y1 - 2019

N2 - IntroductionSequence-based typing of hepatitis A virus (HAV) is important for outbreak detection, investigation and surveillance. In 2013, sequencing was central to resolving a large European Union (EU)-wide outbreak related to frozen berries. However, as the sequenced HAV genome regions were only partly comparable between countries, results were not always conclusive.AimThe objective was to gather information on HAV surveillance and sequencing in EU/European Economic Area (EEA) countries to find ways to harmonise their procedures, for improvement of cross-border outbreak responses.MethodsIn 2014, the European Centre for Disease Prevention and Control (ECDC) conducted a survey on HAV surveillance practices in EU/EEA countries. The survey enquired whether a referral system for confirming primary diagnostics of hepatitis A existed as well as a central collection/storage of hepatitis A cases' samples for typing. Questions on HAV sequencing procedures were also asked. Based on the results, an expert consultation proposed harmonised procedures for cross-border outbreak response, in particular regarding sequencing. In 2016, a follow-up survey assessed uptake of suggested methods.ResultsOf 31 EU/EEA countries, 23 (2014) and 27 (2016) participated. Numbers of countries with central collection and storage of HAV positive samples and of those performing sequencing increased from 12 to 15 and 12 to 14 respectively in 2016, with all countries typing an overlapping fragment of 218 nt. However, variation existed in the sequenced genomic regions and their lengths.ConclusionsWhile HAV sequences in EU/EEA countries are comparable for surveillance, collaboration in sharing and comparing these can be further strengthened.

AB - IntroductionSequence-based typing of hepatitis A virus (HAV) is important for outbreak detection, investigation and surveillance. In 2013, sequencing was central to resolving a large European Union (EU)-wide outbreak related to frozen berries. However, as the sequenced HAV genome regions were only partly comparable between countries, results were not always conclusive.AimThe objective was to gather information on HAV surveillance and sequencing in EU/European Economic Area (EEA) countries to find ways to harmonise their procedures, for improvement of cross-border outbreak responses.MethodsIn 2014, the European Centre for Disease Prevention and Control (ECDC) conducted a survey on HAV surveillance practices in EU/EEA countries. The survey enquired whether a referral system for confirming primary diagnostics of hepatitis A existed as well as a central collection/storage of hepatitis A cases' samples for typing. Questions on HAV sequencing procedures were also asked. Based on the results, an expert consultation proposed harmonised procedures for cross-border outbreak response, in particular regarding sequencing. In 2016, a follow-up survey assessed uptake of suggested methods.ResultsOf 31 EU/EEA countries, 23 (2014) and 27 (2016) participated. Numbers of countries with central collection and storage of HAV positive samples and of those performing sequencing increased from 12 to 15 and 12 to 14 respectively in 2016, with all countries typing an overlapping fragment of 218 nt. However, variation existed in the sequenced genomic regions and their lengths.ConclusionsWhile HAV sequences in EU/EEA countries are comparable for surveillance, collaboration in sharing and comparing these can be further strengthened.

U2 - 10.2807/1560-7917.ES.2019.24.28.1800397

DO - 10.2807/1560-7917.ES.2019.24.28.1800397

M3 - Journal article

VL - 24

JO - Eurosurveillance

JF - Eurosurveillance

SN - 1560-7917

IS - 28

ER -

ID: 57880022