Improvements in glucose metabolism early after gastric bypass surgery are not explained by increases in total bile acids and fibroblast growth factor 19 concentrations

Nils B Jørgensen; Carsten Dirksen; Kirstine N Bojsen-Møller; Viggo B Kristiansen; Birgitte S Wulff; Dominique Rainteau; Lydie Humbert; Jens F Rehfeld; Jens J Holst; Sten Madsbad; Trine R Clausen

doi:10.1210/jc.2014-1658

Improvements in glucose metabolism early after gastric bypass surgery are not explained by increases in total bile acids and fibroblast growth factor 19 concentrations

Nils B Jørgensen, Carsten Dirksen, Kirstine N Bojsen-Møller, Viggo B Kristiansen, Birgitte S Wulff, Dominique Rainteau, Lydie Humbert, Jens F Rehfeld, Jens J Holst, Sten Madsbad, Trine R Clausen

93 Citationer (Scopus)

Abstract

CONTEXT: Bile acids and fibroblast growth factor 19 (FGF19) have been suggested as key mediators of the improvements in glucose metabolism after Roux-en-Y gastric bypass (RYGB).

OBJECTIVE: To describe fasting and postprandial state total bile acid (TBA) and FGF19 concentrations before and after RYGB and relate them to parameters of glucose metabolism, GLP-1, CCK and cholesterol fractions.

DESIGN & SETTING: Prospective descriptive study, performed at the Department of Endocrinology, Hvidovre Hospital, Hvidovre, Denmark.

PATIENTS: 13 type 2 diabetic (T2D) patients and 12 normal glucose tolerant (NGT) subjects.

INTERVENTION: Four-hour liquid meal test performed before, 1 week, 3 months and 1 year after RYGB.

MAIN OUTCOME MEASURES: Fasting and postprandial TBA and FGF19 concentrations.

RESULTS: Fasting TBA concentrations decreased in NGT subjects (p<0.001) and were unchanged in T2D patients one week after surgery, but then increased gradually in both groups with time from surgery (ANOVA ptime<0.001). AUC TBA was decreased in NGT subjects 1 week after RYGB (pre: 567 mmol x min/L [481-826], 1wk: 419 [381-508], p=0.009) and unchanged in T2D patients (894 [573-1002], 695 [349-1147]; p=0.97) but then increased with time from surgery in both groups (ptime<0.001). Fasting FGF19 concentrations were unchanged acutely after RYGB (NGT: 140 pg/mL [100-162]; 134 [119-204], p=0.42; T2D: 162 [130-196], 154 [104-164], p=0.68) and remained unchanged throughout the follow-up period. AUC FGF19 increased gradually with time after surgery (ptime<0.001), resembling the changes seen with AUC TBA. One week after RYGB, glucose metabolism improved, LDL- and HDL-Cholesterol decreased, CCK and GLP-1 secretion increased, whilst FFA concentrations were unchanged.

CONCLUSION: TBA and FGF19 do not explain acute changes in glucose metabolism, cholesterol fractions and gut hormone secretion after RYGB.

Originalsprog	Engelsk
Tidsskrift	The Journal of clinical endocrinology and metabolism
Vol/bind	100
Udgave nummer	3
Sider (fra-til)	E396-406
ISSN	0021-972X
DOI	https://doi.org/10.1210/jc.2014-1658
Status	Udgivet - 2015

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10.1210/jc.2014-1658

Citationsformater

Jørgensen, N. B., Dirksen, C., Bojsen-Møller, K. N., Kristiansen, V. B., Wulff, B. S., Rainteau, D., Humbert, L., Rehfeld, J. F., Holst, J. J., Madsbad, S., & Clausen, T. R. (2015). Improvements in glucose metabolism early after gastric bypass surgery are not explained by increases in total bile acids and fibroblast growth factor 19 concentrations. The Journal of clinical endocrinology and metabolism, 100(3), E396-406. https://doi.org/10.1210/jc.2014-1658

Improvements in glucose metabolism early after gastric bypass surgery are not explained by increases in total bile acids and fibroblast growth factor 19 concentrations. / Jørgensen, Nils B; Dirksen, Carsten ; Bojsen-Møller, Kirstine N et al.
I: The Journal of clinical endocrinology and metabolism, Bind 100, Nr. 3, 2015, s. E396-406.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Jørgensen, NB, Dirksen, C , Bojsen-Møller, KN , Kristiansen, VB, Wulff, BS, Rainteau, D, Humbert, L, Rehfeld, JF, Holst, JJ, Madsbad, S & Clausen, TR 2015, 'Improvements in glucose metabolism early after gastric bypass surgery are not explained by increases in total bile acids and fibroblast growth factor 19 concentrations', The Journal of clinical endocrinology and metabolism, bind 100, nr. 3, s. E396-406. https://doi.org/10.1210/jc.2014-1658

@article{8584f03667b04e08b6e19d58db60ad5b,

title = "Improvements in glucose metabolism early after gastric bypass surgery are not explained by increases in total bile acids and fibroblast growth factor 19 concentrations",

abstract = "CONTEXT: Bile acids and fibroblast growth factor 19 (FGF19) have been suggested as key mediators of the improvements in glucose metabolism after Roux-en-Y gastric bypass (RYGB).OBJECTIVE: To describe fasting and postprandial state total bile acid (TBA) and FGF19 concentrations before and after RYGB and relate them to parameters of glucose metabolism, GLP-1, CCK and cholesterol fractions.DESIGN & SETTING: Prospective descriptive study, performed at the Department of Endocrinology, Hvidovre Hospital, Hvidovre, Denmark.PATIENTS: 13 type 2 diabetic (T2D) patients and 12 normal glucose tolerant (NGT) subjects.INTERVENTION: Four-hour liquid meal test performed before, 1 week, 3 months and 1 year after RYGB.MAIN OUTCOME MEASURES: Fasting and postprandial TBA and FGF19 concentrations.RESULTS: Fasting TBA concentrations decreased in NGT subjects (p<0.001) and were unchanged in T2D patients one week after surgery, but then increased gradually in both groups with time from surgery (ANOVA ptime<0.001). AUC TBA was decreased in NGT subjects 1 week after RYGB (pre: 567 mmol x min/L [481-826], 1wk: 419 [381-508], p=0.009) and unchanged in T2D patients (894 [573-1002], 695 [349-1147]; p=0.97) but then increased with time from surgery in both groups (ptime<0.001). Fasting FGF19 concentrations were unchanged acutely after RYGB (NGT: 140 pg/mL [100-162]; 134 [119-204], p=0.42; T2D: 162 [130-196], 154 [104-164], p=0.68) and remained unchanged throughout the follow-up period. AUC FGF19 increased gradually with time after surgery (ptime<0.001), resembling the changes seen with AUC TBA. One week after RYGB, glucose metabolism improved, LDL- and HDL-Cholesterol decreased, CCK and GLP-1 secretion increased, whilst FFA concentrations were unchanged.CONCLUSION: TBA and FGF19 do not explain acute changes in glucose metabolism, cholesterol fractions and gut hormone secretion after RYGB.",

author = "J{\o}rgensen, {Nils B} and Carsten Dirksen and Bojsen-M{\o}ller, {Kirstine N} and Kristiansen, {Viggo B} and Wulff, {Birgitte S} and Dominique Rainteau and Lydie Humbert and Rehfeld, {Jens F} and Holst, {Jens J} and Sten Madsbad and Clausen, {Trine R}",

year = "2015",

doi = "10.1210/jc.2014-1658",

language = "English",

volume = "100",

pages = "E396--406",

journal = "The Journal of clinical endocrinology and metabolism",

issn = "0021-972X",

publisher = "Endocrine Society",

number = "3",

}

TY - JOUR

T1 - Improvements in glucose metabolism early after gastric bypass surgery are not explained by increases in total bile acids and fibroblast growth factor 19 concentrations

AU - Jørgensen, Nils B

AU - Dirksen, Carsten

AU - Bojsen-Møller, Kirstine N

AU - Kristiansen, Viggo B

AU - Wulff, Birgitte S

AU - Rainteau, Dominique

AU - Humbert, Lydie

AU - Rehfeld, Jens F

AU - Holst, Jens J

AU - Madsbad, Sten

AU - Clausen, Trine R

PY - 2015

Y1 - 2015

N2 - CONTEXT: Bile acids and fibroblast growth factor 19 (FGF19) have been suggested as key mediators of the improvements in glucose metabolism after Roux-en-Y gastric bypass (RYGB).OBJECTIVE: To describe fasting and postprandial state total bile acid (TBA) and FGF19 concentrations before and after RYGB and relate them to parameters of glucose metabolism, GLP-1, CCK and cholesterol fractions.DESIGN & SETTING: Prospective descriptive study, performed at the Department of Endocrinology, Hvidovre Hospital, Hvidovre, Denmark.PATIENTS: 13 type 2 diabetic (T2D) patients and 12 normal glucose tolerant (NGT) subjects.INTERVENTION: Four-hour liquid meal test performed before, 1 week, 3 months and 1 year after RYGB.MAIN OUTCOME MEASURES: Fasting and postprandial TBA and FGF19 concentrations.RESULTS: Fasting TBA concentrations decreased in NGT subjects (p<0.001) and were unchanged in T2D patients one week after surgery, but then increased gradually in both groups with time from surgery (ANOVA ptime<0.001). AUC TBA was decreased in NGT subjects 1 week after RYGB (pre: 567 mmol x min/L [481-826], 1wk: 419 [381-508], p=0.009) and unchanged in T2D patients (894 [573-1002], 695 [349-1147]; p=0.97) but then increased with time from surgery in both groups (ptime<0.001). Fasting FGF19 concentrations were unchanged acutely after RYGB (NGT: 140 pg/mL [100-162]; 134 [119-204], p=0.42; T2D: 162 [130-196], 154 [104-164], p=0.68) and remained unchanged throughout the follow-up period. AUC FGF19 increased gradually with time after surgery (ptime<0.001), resembling the changes seen with AUC TBA. One week after RYGB, glucose metabolism improved, LDL- and HDL-Cholesterol decreased, CCK and GLP-1 secretion increased, whilst FFA concentrations were unchanged.CONCLUSION: TBA and FGF19 do not explain acute changes in glucose metabolism, cholesterol fractions and gut hormone secretion after RYGB.

AB - CONTEXT: Bile acids and fibroblast growth factor 19 (FGF19) have been suggested as key mediators of the improvements in glucose metabolism after Roux-en-Y gastric bypass (RYGB).OBJECTIVE: To describe fasting and postprandial state total bile acid (TBA) and FGF19 concentrations before and after RYGB and relate them to parameters of glucose metabolism, GLP-1, CCK and cholesterol fractions.DESIGN & SETTING: Prospective descriptive study, performed at the Department of Endocrinology, Hvidovre Hospital, Hvidovre, Denmark.PATIENTS: 13 type 2 diabetic (T2D) patients and 12 normal glucose tolerant (NGT) subjects.INTERVENTION: Four-hour liquid meal test performed before, 1 week, 3 months and 1 year after RYGB.MAIN OUTCOME MEASURES: Fasting and postprandial TBA and FGF19 concentrations.RESULTS: Fasting TBA concentrations decreased in NGT subjects (p<0.001) and were unchanged in T2D patients one week after surgery, but then increased gradually in both groups with time from surgery (ANOVA ptime<0.001). AUC TBA was decreased in NGT subjects 1 week after RYGB (pre: 567 mmol x min/L [481-826], 1wk: 419 [381-508], p=0.009) and unchanged in T2D patients (894 [573-1002], 695 [349-1147]; p=0.97) but then increased with time from surgery in both groups (ptime<0.001). Fasting FGF19 concentrations were unchanged acutely after RYGB (NGT: 140 pg/mL [100-162]; 134 [119-204], p=0.42; T2D: 162 [130-196], 154 [104-164], p=0.68) and remained unchanged throughout the follow-up period. AUC FGF19 increased gradually with time after surgery (ptime<0.001), resembling the changes seen with AUC TBA. One week after RYGB, glucose metabolism improved, LDL- and HDL-Cholesterol decreased, CCK and GLP-1 secretion increased, whilst FFA concentrations were unchanged.CONCLUSION: TBA and FGF19 do not explain acute changes in glucose metabolism, cholesterol fractions and gut hormone secretion after RYGB.

U2 - 10.1210/jc.2014-1658

DO - 10.1210/jc.2014-1658

M3 - Journal article

C2 - 25536209

SN - 0021-972X

VL - 100

SP - E396-406

JO - The Journal of clinical endocrinology and metabolism

JF - The Journal of clinical endocrinology and metabolism

IS - 3

ER -

Improvements in glucose metabolism early after gastric bypass surgery are not explained by increases in total bile acids and fibroblast growth factor 19 concentrations

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