Improved Survival in Liver Transplant Patients Receiving Prolonged-release Tacrolimus-based Immunosuppression in the European Liver Transplant Registry (ELTR): An Extension Study

René Adam; Vincent Karam; Valérie Cailliez; Pavel Trunečka; Didier Samuel; Giuseppe Tisone; Petr Němec; Olivier Soubrane; Stefan Schneeberger; Bruno Gridelli; Wolf O Bechstein; Andrea Risaliti; Pal-Dag Line; Marco Vivarelli; Massimo Rossi; Jacques Pirenne; Jurgen L Klempnauer; Aleh Rummo; Fabrizio Di Benedetto; Krzysztof Zieniewicz; Roberto Troisi; Andreas Paul; Toomas Vali; Otto Kollmar; Karim Boudjema; Emir Hoti; Michele Colledan; Johan Pratschke; Hauke Lang; Irinel Popescu; Bo-Goran Ericzon; Kestutis Strupas; Paolo De Simone; Eberhard Kochs; Bruno Heyd; Jean Gugenheim; Antonio D Pinna; William Bennet; Mirjalal Kazimi; Philippe Bachellier; Stephen J Wigmore; Allan Rasmussen; Pierre-Alain Clavien; Ernest Hidalgo; John G O'Grady; Frausto Zamboni; Murat Kilic; Christophe Duvoux; all contributing centers (www.eltr.org) and the European Liver and Intestine Transplant Association (ELITA)

doi:10.1097/TP.0000000000002700

Improved Survival in Liver Transplant Patients Receiving Prolonged-release Tacrolimus-based Immunosuppression in the European Liver Transplant Registry (ELTR): An Extension Study

René Adam, Vincent Karam, Valérie Cailliez, Pavel Trunečka, Didier Samuel, Giuseppe Tisone, Petr Němec, Olivier Soubrane, Stefan Schneeberger, Bruno Gridelli, Wolf O Bechstein, Andrea Risaliti, Pal-Dag Line, Marco Vivarelli, Massimo Rossi, Jacques Pirenne, Jurgen L Klempnauer, Aleh Rummo, Fabrizio Di Benedetto, Krzysztof ZieniewiczRoberto Troisi, Andreas Paul, Toomas Vali, Otto Kollmar, Karim Boudjema, Emir Hoti, Michele Colledan, Johan Pratschke, Hauke Lang, Irinel Popescu, Bo-Goran Ericzon, Kestutis Strupas, Paolo De Simone, Eberhard Kochs, Bruno Heyd, Jean Gugenheim, Antonio D Pinna, William Bennet, Mirjalal Kazimi, Philippe Bachellier, Stephen J Wigmore, Allan Rasmussen, Pierre-Alain Clavien, Ernest Hidalgo, John G O'Grady, Frausto Zamboni, Murat Kilic, Christophe Duvoux, all contributing centers (www.eltr.org) and the European Liver and Intestine Transplant Association (ELITA)

11 Citationer (Scopus)

Abstract

BACKGROUND: We compared, through the European Liver Transplant Registry, long-term liver transplantation outcomes with prolonged-release tacrolimus (PR-T) versus immediate-release tacrolimus (IR-T)-based immunosuppression. This retrospective analysis comprises up to 8-year data collected between 2008 and 2016, in an extension of our previously published study.

METHODS: Patients with <1 month follow-up were excluded; patients were propensity score matched for baseline characteristics. Efficacy measures included: univariate/multivariate analyses of risk factors influencing graft/patient survival up to 8 years posttransplantation, and graft/patient survival up to 4 years with PR-T versus IR-T. Overall, 13 088 patients were included from 44 European centers; propensity score-matched analyses comprised 3006 patients (PR-T: n = 1002; IR-T: n = 2004).

RESULTS: In multivariate analyses, IR-T-based immunosuppression was associated with reduced graft survival (risk ratio, 1.49; P = 0.0038) and patient survival (risk ratio, 1.40; P = 0.0215). There was improvement with PR-T versus IR-T in graft survival (83% versus 77% at 4 y, respectively; P = 0.005) and patient survival (85% versus 80%; P = 0.017). Patients converted from IR-T to PR-T after 1 month had a higher graft survival rate than patients receiving IR-T at last follow-up (P < 0.001), or started and maintained on PR-T (P = 0.019). One graft loss in 4 years was avoided for every 14.3 patients treated with PR-T versus IR-T.

CONCLUSIONS: PR-T-based immunosuppression might improve long-term outcomes in liver transplant recipients than IR-T-based immunosuppression.

Originalsprog	Engelsk
Tidsskrift	Transplantation
Vol/bind	103
Udgave nummer	9
Sider (fra-til)	1844-1862
Antal sider	19
ISSN	0041-1337
DOI	https://doi.org/10.1097/TP.0000000000002700
Status	Udgivet - sep. 2019

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10.1097/TP.0000000000002700

Citationsformater

Adam, R., Karam, V., Cailliez, V., Trunečka, P., Samuel, D., Tisone, G., Němec, P., Soubrane, O., Schneeberger, S., Gridelli, B., Bechstein, W. O., Risaliti, A., Line, P.-D., Vivarelli, M., Rossi, M., Pirenne, J., Klempnauer, J. L., Rummo, A., Di Benedetto, F., ... all contributing centers (www.eltr.org) and the European Liver and Intestine Transplant Association (ELITA) (2019). Improved Survival in Liver Transplant Patients Receiving Prolonged-release Tacrolimus-based Immunosuppression in the European Liver Transplant Registry (ELTR): An Extension Study. Transplantation, 103(9), 1844-1862. https://doi.org/10.1097/TP.0000000000002700

Improved Survival in Liver Transplant Patients Receiving Prolonged-release Tacrolimus-based Immunosuppression in the European Liver Transplant Registry (ELTR): An Extension Study. / Adam, René; Karam, Vincent; Cailliez, Valérie et al.
I: Transplantation, Bind 103, Nr. 9, 09.2019, s. 1844-1862.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Adam, R, Karam, V, Cailliez, V, Trunečka, P, Samuel, D, Tisone, G, Němec, P, Soubrane, O, Schneeberger, S, Gridelli, B, Bechstein, WO, Risaliti, A, Line, P-D, Vivarelli, M, Rossi, M, Pirenne, J, Klempnauer, JL, Rummo, A, Di Benedetto, F, Zieniewicz, K, Troisi, R, Paul, A, Vali, T, Kollmar, O, Boudjema, K, Hoti, E, Colledan, M, Pratschke, J, Lang, H, Popescu, I, Ericzon, B-G, Strupas, K, De Simone, P, Kochs, E, Heyd, B, Gugenheim, J, Pinna, AD, Bennet, W, Kazimi, M, Bachellier, P, Wigmore, SJ, Rasmussen, A, Clavien, P-A, Hidalgo, E, O'Grady, JG, Zamboni, F, Kilic, M, Duvoux, C & all contributing centers (www.eltr.org) and the European Liver and Intestine Transplant Association (ELITA) 2019, 'Improved Survival in Liver Transplant Patients Receiving Prolonged-release Tacrolimus-based Immunosuppression in the European Liver Transplant Registry (ELTR): An Extension Study', Transplantation, bind 103, nr. 9, s. 1844-1862. https://doi.org/10.1097/TP.0000000000002700

@article{d1fdf453d9f24cbf8c0fc01b4b65ac90,

title = "Improved Survival in Liver Transplant Patients Receiving Prolonged-release Tacrolimus-based Immunosuppression in the European Liver Transplant Registry (ELTR): An Extension Study",

abstract = "BACKGROUND: We compared, through the European Liver Transplant Registry, long-term liver transplantation outcomes with prolonged-release tacrolimus (PR-T) versus immediate-release tacrolimus (IR-T)-based immunosuppression. This retrospective analysis comprises up to 8-year data collected between 2008 and 2016, in an extension of our previously published study.METHODS: Patients with <1 month follow-up were excluded; patients were propensity score matched for baseline characteristics. Efficacy measures included: univariate/multivariate analyses of risk factors influencing graft/patient survival up to 8 years posttransplantation, and graft/patient survival up to 4 years with PR-T versus IR-T. Overall, 13 088 patients were included from 44 European centers; propensity score-matched analyses comprised 3006 patients (PR-T: n = 1002; IR-T: n = 2004).RESULTS: In multivariate analyses, IR-T-based immunosuppression was associated with reduced graft survival (risk ratio, 1.49; P = 0.0038) and patient survival (risk ratio, 1.40; P = 0.0215). There was improvement with PR-T versus IR-T in graft survival (83% versus 77% at 4 y, respectively; P = 0.005) and patient survival (85% versus 80%; P = 0.017). Patients converted from IR-T to PR-T after 1 month had a higher graft survival rate than patients receiving IR-T at last follow-up (P < 0.001), or started and maintained on PR-T (P = 0.019). One graft loss in 4 years was avoided for every 14.3 patients treated with PR-T versus IR-T.CONCLUSIONS: PR-T-based immunosuppression might improve long-term outcomes in liver transplant recipients than IR-T-based immunosuppression.",

author = "Ren{\'e} Adam and Vincent Karam and Val{\'e}rie Cailliez and Pavel Trune{\v c}ka and Didier Samuel and Giuseppe Tisone and Petr N{\v e}mec and Olivier Soubrane and Stefan Schneeberger and Bruno Gridelli and Bechstein, {Wolf O} and Andrea Risaliti and Pal-Dag Line and Marco Vivarelli and Massimo Rossi and Jacques Pirenne and Klempnauer, {Jurgen L} and Aleh Rummo and {Di Benedetto}, Fabrizio and Krzysztof Zieniewicz and Roberto Troisi and Andreas Paul and Toomas Vali and Otto Kollmar and Karim Boudjema and Emir Hoti and Michele Colledan and Johan Pratschke and Hauke Lang and Irinel Popescu and Bo-Goran Ericzon and Kestutis Strupas and {De Simone}, Paolo and Eberhard Kochs and Bruno Heyd and Jean Gugenheim and Pinna, {Antonio D} and William Bennet and Mirjalal Kazimi and Philippe Bachellier and Wigmore, {Stephen J} and Allan Rasmussen and Pierre-Alain Clavien and Ernest Hidalgo and O'Grady, {John G} and Frausto Zamboni and Murat Kilic and Christophe Duvoux and {all contributing centers (www.eltr.org) and the European Liver and Intestine Transplant Association (ELITA)}",

year = "2019",

month = sep,

doi = "10.1097/TP.0000000000002700",

language = "English",

volume = "103",

pages = "1844--1862",

journal = "Transplantation",

issn = "0041-1337",

publisher = "Lippincott Williams and Wilkins",

number = "9",

}

TY - JOUR

T1 - Improved Survival in Liver Transplant Patients Receiving Prolonged-release Tacrolimus-based Immunosuppression in the European Liver Transplant Registry (ELTR)

T2 - An Extension Study

AU - Adam, René

AU - Karam, Vincent

AU - Cailliez, Valérie

AU - Trunečka, Pavel

AU - Samuel, Didier

AU - Tisone, Giuseppe

AU - Němec, Petr

AU - Soubrane, Olivier

AU - Schneeberger, Stefan

AU - Gridelli, Bruno

AU - Bechstein, Wolf O

AU - Risaliti, Andrea

AU - Line, Pal-Dag

AU - Vivarelli, Marco

AU - Rossi, Massimo

AU - Pirenne, Jacques

AU - Klempnauer, Jurgen L

AU - Rummo, Aleh

AU - Di Benedetto, Fabrizio

AU - Zieniewicz, Krzysztof

AU - Troisi, Roberto

AU - Paul, Andreas

AU - Vali, Toomas

AU - Kollmar, Otto

AU - Boudjema, Karim

AU - Hoti, Emir

AU - Colledan, Michele

AU - Pratschke, Johan

AU - Lang, Hauke

AU - Popescu, Irinel

AU - Ericzon, Bo-Goran

AU - Strupas, Kestutis

AU - De Simone, Paolo

AU - Kochs, Eberhard

AU - Heyd, Bruno

AU - Gugenheim, Jean

AU - Pinna, Antonio D

AU - Bennet, William

AU - Kazimi, Mirjalal

AU - Bachellier, Philippe

AU - Wigmore, Stephen J

AU - Rasmussen, Allan

AU - Clavien, Pierre-Alain

AU - Hidalgo, Ernest

AU - O'Grady, John G

AU - Zamboni, Frausto

AU - Kilic, Murat

AU - Duvoux, Christophe

AU - all contributing centers (www.eltr.org) and the European Liver and Intestine Transplant Association (ELITA)

PY - 2019/9

Y1 - 2019/9

N2 - BACKGROUND: We compared, through the European Liver Transplant Registry, long-term liver transplantation outcomes with prolonged-release tacrolimus (PR-T) versus immediate-release tacrolimus (IR-T)-based immunosuppression. This retrospective analysis comprises up to 8-year data collected between 2008 and 2016, in an extension of our previously published study.METHODS: Patients with <1 month follow-up were excluded; patients were propensity score matched for baseline characteristics. Efficacy measures included: univariate/multivariate analyses of risk factors influencing graft/patient survival up to 8 years posttransplantation, and graft/patient survival up to 4 years with PR-T versus IR-T. Overall, 13 088 patients were included from 44 European centers; propensity score-matched analyses comprised 3006 patients (PR-T: n = 1002; IR-T: n = 2004).RESULTS: In multivariate analyses, IR-T-based immunosuppression was associated with reduced graft survival (risk ratio, 1.49; P = 0.0038) and patient survival (risk ratio, 1.40; P = 0.0215). There was improvement with PR-T versus IR-T in graft survival (83% versus 77% at 4 y, respectively; P = 0.005) and patient survival (85% versus 80%; P = 0.017). Patients converted from IR-T to PR-T after 1 month had a higher graft survival rate than patients receiving IR-T at last follow-up (P < 0.001), or started and maintained on PR-T (P = 0.019). One graft loss in 4 years was avoided for every 14.3 patients treated with PR-T versus IR-T.CONCLUSIONS: PR-T-based immunosuppression might improve long-term outcomes in liver transplant recipients than IR-T-based immunosuppression.

AB - BACKGROUND: We compared, through the European Liver Transplant Registry, long-term liver transplantation outcomes with prolonged-release tacrolimus (PR-T) versus immediate-release tacrolimus (IR-T)-based immunosuppression. This retrospective analysis comprises up to 8-year data collected between 2008 and 2016, in an extension of our previously published study.METHODS: Patients with <1 month follow-up were excluded; patients were propensity score matched for baseline characteristics. Efficacy measures included: univariate/multivariate analyses of risk factors influencing graft/patient survival up to 8 years posttransplantation, and graft/patient survival up to 4 years with PR-T versus IR-T. Overall, 13 088 patients were included from 44 European centers; propensity score-matched analyses comprised 3006 patients (PR-T: n = 1002; IR-T: n = 2004).RESULTS: In multivariate analyses, IR-T-based immunosuppression was associated with reduced graft survival (risk ratio, 1.49; P = 0.0038) and patient survival (risk ratio, 1.40; P = 0.0215). There was improvement with PR-T versus IR-T in graft survival (83% versus 77% at 4 y, respectively; P = 0.005) and patient survival (85% versus 80%; P = 0.017). Patients converted from IR-T to PR-T after 1 month had a higher graft survival rate than patients receiving IR-T at last follow-up (P < 0.001), or started and maintained on PR-T (P = 0.019). One graft loss in 4 years was avoided for every 14.3 patients treated with PR-T versus IR-T.CONCLUSIONS: PR-T-based immunosuppression might improve long-term outcomes in liver transplant recipients than IR-T-based immunosuppression.

U2 - 10.1097/TP.0000000000002700

DO - 10.1097/TP.0000000000002700

M3 - Journal article

C2 - 31343568

SN - 0041-1337

VL - 103

SP - 1844

EP - 1862

JO - Transplantation

JF - Transplantation

IS - 9

ER -

Improved Survival in Liver Transplant Patients Receiving Prolonged-release Tacrolimus-based Immunosuppression in the European Liver Transplant Registry (ELTR): An Extension Study

Abstract

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