Improved glycemic control induced by both metformin and repaglinide is associated with a reduction in blood levels of 3-deoxyglucosone in nonobese patients with type 2 diabetes

Lian Engelen, Søren Lund, Isabel Ferreira, Lise Tarnow, Hans-Henrik Parving, Jørgen Brodersen Gram, Kaj Winther, Oluf Borbye Pedersen, Tom Teerlink, Rob Barto, Coen D A Stehouwer, Allan A Vaag, Casper G Schalkwijk

    15 Citationer (Scopus)

    Abstract

    Metformin has been reported to reduce α-dicarbonyls, which are known to contribute to diabetic complications. It is unclear whether this is due to direct quenching of α-dicarbonyls or to an improvement in glycemic control. We therefore compared the effects of metformin versus repaglinide, an antihyperglycemic agent with an insulin-secreting mechanism, on the levels of the α-dicarbonyl 3-deoxyglucosone (3DG).
    OriginalsprogEngelsk
    TidsskriftEuropean Journal of Endocrinology
    Vol/bind164
    Udgave nummer3
    Sider (fra-til)371-9
    Antal sider9
    ISSN0804-4643
    DOI
    StatusUdgivet - 2011

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