Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma

Christian Mirian, Kathrine Grell, Tareq A Juratli, Felix Sahm, Sabine Spiegl-Kreinecker, Matthieu Peyre, Annamaria Biczok, Joerg Christian Tonn, Stéphane Goutagny, Luca Bertero, Andrea Daniela Maier, Lasse Rehné Jensen, Gabriele Schackert, Helle Broholm, David Scheie, Daniel P Cahill, Priscilla K Brastianos, Jane Skjøth-Rasmussen, Kåre Fugleholm, Morten ZiebellTina Nørgaard Munch, Bjarne Winther Kristensen, Tiit Mathiesen

Abstract

TERT promoter mutations have been associated with increased risk of recurrence in meningioma cohorts, thus a potential biomarker for aggressive phenotypes. A main purpose of refining tumour classification is better predictions on the patient level. We compiled data from previous published cohorts to investigate patient-level predictions of recurrence based on TERTp-mut status. Implementation of TERTp-mut into the WHO grading led to better patient prognostication by improved prediction of recurrence. Our results support implementation of TERTp-mut into diagnostics and classification of meningiomas.

OriginalsprogEngelsk
Artikelnummere12773
TidsskriftNeuropathology and Applied Neurobiology
Vol/bind48
Udgave nummer3
Sider (fra-til)1-5
Antal sider5
ISSN0305-1846
DOI
StatusUdgivet - apr. 2022

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