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Implants induce a new niche for microbiomes

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Harvard

Jakobsen, TH, Eickhardt, SR, Gheorghe, AG, Stenqvist, C, Sønderholm, M, Stavnsberg, C, Jensen, PØ, Odgaard, A, Whiteley, M, Moser, C, Hvolris, J, Hougen, HP & Bjarnsholt, T 2018, 'Implants induce a new niche for microbiomes' APMIS - Journal of Pathology, Microbiology and Immunology, bind 126, nr. 8, s. 685-692. https://doi.org/10.1111/apm.12862

APA

Jakobsen, T. H., Eickhardt, S. R., Gheorghe, A. G., Stenqvist, C., Sønderholm, M., Stavnsberg, C., ... Bjarnsholt, T. (2018). Implants induce a new niche for microbiomes. APMIS - Journal of Pathology, Microbiology and Immunology, 126(8), 685-692. https://doi.org/10.1111/apm.12862

CBE

Jakobsen TH, Eickhardt SR, Gheorghe AG, Stenqvist C, Sønderholm M, Stavnsberg C, Jensen PØ, Odgaard A, Whiteley M, Moser C, Hvolris J, Hougen HP, Bjarnsholt T. 2018. Implants induce a new niche for microbiomes. APMIS - Journal of Pathology, Microbiology and Immunology. 126(8):685-692. https://doi.org/10.1111/apm.12862

MLA

Vancouver

Jakobsen TH, Eickhardt SR, Gheorghe AG, Stenqvist C, Sønderholm M, Stavnsberg C o.a. Implants induce a new niche for microbiomes. APMIS - Journal of Pathology, Microbiology and Immunology. 2018 aug;126(8):685-692. https://doi.org/10.1111/apm.12862

Author

Jakobsen, Tim H ; Eickhardt, Steffen R ; Gheorghe, Alexandra G ; Stenqvist, Charlotte ; Sønderholm, Majken ; Stavnsberg, Camilla ; Jensen, Peter Ø ; Odgaard, Anders ; Whiteley, Marvin ; Moser, Claus ; Hvolris, Jesper ; Hougen, Hans Petter ; Bjarnsholt, Thomas. / Implants induce a new niche for microbiomes. I: APMIS - Journal of Pathology, Microbiology and Immunology. 2018 ; Bind 126, Nr. 8. s. 685-692.

Bibtex

@article{bd38fcc6dcad40e2a775a55c2650466c,
title = "Implants induce a new niche for microbiomes",
abstract = "Although much work is being done to develop new treatments, research and knowledge regarding factors underlying implant-related microbial colonization leading to infection are less comprehensive. Presence of microorganisms in and around implants clinically characterized as uninfected remains unknown. The objective of this study was to detect and identify bacteria and fungi on implants from various groups of patients with no prior indications of implant related infections. Patient samples (implants and tissue) were collected from five different hospitals in the Capital region of Denmark. By in-depth microbiological detection methods, we examined the prevalence of bacteria and fungi on 106 clinically uninfected implants from four patient groups (aseptic loosening, healed fractures, craniofacial complications and recently deceased). Of 106 clinically uninfected implants and 39 negative controls investigated, 66{\%} were colonized by bacteria and 40{\%} were colonized by fungi (p < 0.0001 compared to negative controls). A large number of microbes were found to colonize the implants, however, the most prevalent microbes present were not common aetiological agents of implant infections. The findings indicate that implants provide a distinct niche for microbial colonization. These data have broad implications for medical implant recipients, as well as for supporting the idea that the presence of foreign objects in the body alters the human microbiome by providing new colonization niches.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Bacteria/classification, Bacterial Typing Techniques, Bone Regeneration/physiology, Case-Control Studies, Female, Foreign Bodies/microbiology, Fractures, Bone/microbiology, Fungi/classification, Humans, Male, Middle Aged, Mycological Typing Techniques, Prostheses and Implants/microbiology, Prosthesis Failure, Prosthesis-Related Infections/microbiology",
author = "Jakobsen, {Tim H} and Eickhardt, {Steffen R} and Gheorghe, {Alexandra G} and Charlotte Stenqvist and Majken S{\o}nderholm and Camilla Stavnsberg and Jensen, {Peter {\O}} and Anders Odgaard and Marvin Whiteley and Claus Moser and Jesper Hvolris and Hougen, {Hans Petter} and Thomas Bjarnsholt",
note = "{\circledC} 2018 APMIS. Published by John Wiley & Sons Ltd.",
year = "2018",
month = "8",
doi = "10.1111/apm.12862",
language = "English",
volume = "126",
pages = "685--692",
journal = "APMIS - Journal of Pathology, Microbiology and Immunology",
issn = "0903-4641",
publisher = "Wiley Online",
number = "8",

}

RIS

TY - JOUR

T1 - Implants induce a new niche for microbiomes

AU - Jakobsen, Tim H

AU - Eickhardt, Steffen R

AU - Gheorghe, Alexandra G

AU - Stenqvist, Charlotte

AU - Sønderholm, Majken

AU - Stavnsberg, Camilla

AU - Jensen, Peter Ø

AU - Odgaard, Anders

AU - Whiteley, Marvin

AU - Moser, Claus

AU - Hvolris, Jesper

AU - Hougen, Hans Petter

AU - Bjarnsholt, Thomas

N1 - © 2018 APMIS. Published by John Wiley & Sons Ltd.

PY - 2018/8

Y1 - 2018/8

N2 - Although much work is being done to develop new treatments, research and knowledge regarding factors underlying implant-related microbial colonization leading to infection are less comprehensive. Presence of microorganisms in and around implants clinically characterized as uninfected remains unknown. The objective of this study was to detect and identify bacteria and fungi on implants from various groups of patients with no prior indications of implant related infections. Patient samples (implants and tissue) were collected from five different hospitals in the Capital region of Denmark. By in-depth microbiological detection methods, we examined the prevalence of bacteria and fungi on 106 clinically uninfected implants from four patient groups (aseptic loosening, healed fractures, craniofacial complications and recently deceased). Of 106 clinically uninfected implants and 39 negative controls investigated, 66% were colonized by bacteria and 40% were colonized by fungi (p < 0.0001 compared to negative controls). A large number of microbes were found to colonize the implants, however, the most prevalent microbes present were not common aetiological agents of implant infections. The findings indicate that implants provide a distinct niche for microbial colonization. These data have broad implications for medical implant recipients, as well as for supporting the idea that the presence of foreign objects in the body alters the human microbiome by providing new colonization niches.

AB - Although much work is being done to develop new treatments, research and knowledge regarding factors underlying implant-related microbial colonization leading to infection are less comprehensive. Presence of microorganisms in and around implants clinically characterized as uninfected remains unknown. The objective of this study was to detect and identify bacteria and fungi on implants from various groups of patients with no prior indications of implant related infections. Patient samples (implants and tissue) were collected from five different hospitals in the Capital region of Denmark. By in-depth microbiological detection methods, we examined the prevalence of bacteria and fungi on 106 clinically uninfected implants from four patient groups (aseptic loosening, healed fractures, craniofacial complications and recently deceased). Of 106 clinically uninfected implants and 39 negative controls investigated, 66% were colonized by bacteria and 40% were colonized by fungi (p < 0.0001 compared to negative controls). A large number of microbes were found to colonize the implants, however, the most prevalent microbes present were not common aetiological agents of implant infections. The findings indicate that implants provide a distinct niche for microbial colonization. These data have broad implications for medical implant recipients, as well as for supporting the idea that the presence of foreign objects in the body alters the human microbiome by providing new colonization niches.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Bacteria/classification

KW - Bacterial Typing Techniques

KW - Bone Regeneration/physiology

KW - Case-Control Studies

KW - Female

KW - Foreign Bodies/microbiology

KW - Fractures, Bone/microbiology

KW - Fungi/classification

KW - Humans

KW - Male

KW - Middle Aged

KW - Mycological Typing Techniques

KW - Prostheses and Implants/microbiology

KW - Prosthesis Failure

KW - Prosthesis-Related Infections/microbiology

U2 - 10.1111/apm.12862

DO - 10.1111/apm.12862

M3 - Journal article

VL - 126

SP - 685

EP - 692

JO - APMIS - Journal of Pathology, Microbiology and Immunology

JF - APMIS - Journal of Pathology, Microbiology and Immunology

SN - 0903-4641

IS - 8

ER -

ID: 56273471