Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Impaired pancreatic polypeptide response to a meal in type 1 diabetic patients: vagal neuropathy or islet cell dysfunction?

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{e45568ffeec942c5b89da59297e3a10d,
title = "Impaired pancreatic polypeptide response to a meal in type 1 diabetic patients: vagal neuropathy or islet cell dysfunction?",
abstract = "The pancreatic polypeptide (PP) response to a mixed meal was investigated in seven insulin-dependent diabetics without measurable signs of diabetic autonomic neuropathy, and in seven healthy subjects. Since acute changes in metabolic regulation might influence the meal-induced PP response, the insulin-dependent diabetic patients were studied during normo- and hyperglycemic experimental conditions at blood glucose levels of 5 and 15 mmol/l, respectively. The PP response was identical on the two occasions, the response being significantly smaller than in the healthy subjects. Thus, PP response is independent of short-term changes in metabolic control. Since the response was attenuated in the insulin-dependent diabetic patients, who had no otherwise measurable signs of neuropathy, the PP response to a meal could be a sensitive indicator of dysfunction of the reflex arc controlling PP secretion in insulin-dependent diabetic patients. Alternatively, the reduction in PP secretion in these patients reflects dysfunction of the PP secreting cells of the pancreas. Iv injection of cholecystokinin-8 elicited a small but significant increase in PP concentrations, while iv secretin did not increase PP concentrations at all in healthy subjects. These stimuli are therefore less suitable in the assessment of vagal neuropathy.",
keywords = "Adult, Blood Glucose, Caerulein, Diabetes Mellitus, Type 1, Diabetic Neuropathies, Female, Food, Humans, Injections, Intravenous, Islets of Langerhans, Male, Pancreatic Polypeptide, Radioimmunoassay, Secretin, Time Factors, Vagus Nerve",
author = "Rasmussen, {M H} and H Carstensen and S List and Tania Schwartz and J Hilsted",
year = "1993",
month = "3",
language = "English",
volume = "128",
pages = "221--4",
journal = "Acta Endocrinologica",
issn = "0001-5598",
publisher = "Periodica",
number = "3",

}

RIS

TY - JOUR

T1 - Impaired pancreatic polypeptide response to a meal in type 1 diabetic patients

T2 - vagal neuropathy or islet cell dysfunction?

AU - Rasmussen, M H

AU - Carstensen, H

AU - List, S

AU - Schwartz, Tania

AU - Hilsted, J

PY - 1993/3

Y1 - 1993/3

N2 - The pancreatic polypeptide (PP) response to a mixed meal was investigated in seven insulin-dependent diabetics without measurable signs of diabetic autonomic neuropathy, and in seven healthy subjects. Since acute changes in metabolic regulation might influence the meal-induced PP response, the insulin-dependent diabetic patients were studied during normo- and hyperglycemic experimental conditions at blood glucose levels of 5 and 15 mmol/l, respectively. The PP response was identical on the two occasions, the response being significantly smaller than in the healthy subjects. Thus, PP response is independent of short-term changes in metabolic control. Since the response was attenuated in the insulin-dependent diabetic patients, who had no otherwise measurable signs of neuropathy, the PP response to a meal could be a sensitive indicator of dysfunction of the reflex arc controlling PP secretion in insulin-dependent diabetic patients. Alternatively, the reduction in PP secretion in these patients reflects dysfunction of the PP secreting cells of the pancreas. Iv injection of cholecystokinin-8 elicited a small but significant increase in PP concentrations, while iv secretin did not increase PP concentrations at all in healthy subjects. These stimuli are therefore less suitable in the assessment of vagal neuropathy.

AB - The pancreatic polypeptide (PP) response to a mixed meal was investigated in seven insulin-dependent diabetics without measurable signs of diabetic autonomic neuropathy, and in seven healthy subjects. Since acute changes in metabolic regulation might influence the meal-induced PP response, the insulin-dependent diabetic patients were studied during normo- and hyperglycemic experimental conditions at blood glucose levels of 5 and 15 mmol/l, respectively. The PP response was identical on the two occasions, the response being significantly smaller than in the healthy subjects. Thus, PP response is independent of short-term changes in metabolic control. Since the response was attenuated in the insulin-dependent diabetic patients, who had no otherwise measurable signs of neuropathy, the PP response to a meal could be a sensitive indicator of dysfunction of the reflex arc controlling PP secretion in insulin-dependent diabetic patients. Alternatively, the reduction in PP secretion in these patients reflects dysfunction of the PP secreting cells of the pancreas. Iv injection of cholecystokinin-8 elicited a small but significant increase in PP concentrations, while iv secretin did not increase PP concentrations at all in healthy subjects. These stimuli are therefore less suitable in the assessment of vagal neuropathy.

KW - Adult

KW - Blood Glucose

KW - Caerulein

KW - Diabetes Mellitus, Type 1

KW - Diabetic Neuropathies

KW - Female

KW - Food

KW - Humans

KW - Injections, Intravenous

KW - Islets of Langerhans

KW - Male

KW - Pancreatic Polypeptide

KW - Radioimmunoassay

KW - Secretin

KW - Time Factors

KW - Vagus Nerve

M3 - Journal article

VL - 128

SP - 221

EP - 224

JO - Acta Endocrinologica

JF - Acta Endocrinologica

SN - 0001-5598

IS - 3

ER -

ID: 40201442